Dermal Matrices and Bioengineered Skin Substitutes: A Critical Review of Current Options

Debels, Heidi; Hamdi, Moustapha; Abberton, Keren; Morrison, Wayne

doi:10.1097/gox.0000000000000219

Cited by 227Tissue Engineering and Regenerative MedicineWound Healing and TreatmentsElectrospun Nanofibers in Biomedical Applications

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Dermal Matrices and Bioengineered Skin Substitutes: A Critical Review of Current Options

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Debels, Heidi, Hamdi, Moustapha, Abberton, Keren, Morrison, Wayne·2015·Plastic and Reconstructive Surgery Global Open

DOI 10.1097/gox.0000000000000219PMC PMC4323388

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Abstract

BACKGROUND: Over recent decades, scientists and surgeons have collaborated to develop various bioengineered and synthetic products as an alternative to skin grafts. Despite the numerous articles and reviews written about dermal skin substitutes, there is no general consensus. METHODS: This article reviews dermal skin scaffolds used in clinical applications and experimental settings. For scaffold evaluation, we focused on clinical and/or histological results, and conclusions are listed. Explanations for general trends were sought based on existing knowledge about tissue engineering principles and wound healing mechanisms. RESULTS: Decellularized dermis seems to remain the best option with no other acellular scaffold being clinically proven to gain better results yet. In general, chemically cross-linked products were seen to be less effective in skin tissue engineering. Biocompatibility could be enhanced by preseeding substitutes with fibroblasts to allow some natural scaffold remodeling before product application. CONCLUSIONS: Skin substitutes are a useful tool in plastic and reconstructive surgery practices as an alternative to skin grafts. In the choice of substitute, the general plastic surgery principle of replacing like tissue with like tissue seems to be still standing, and products most resembling the natural dermal extracellular matrix should be preferred.

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Bioengineered tissue models mimic native human tissue more closely than 2D cultures.
“achieving increased biomimicry of native human tissue compared to 2D18,19.”
From Human disease models in drug development (2023) · cites this paper as [18]
The Abstract (Conclusions; page unavailable) describes tissue-engineered skin scaffolds as three-dimensional structures, and the Discussion (page unavailable) considers how skin substitutes differ from native human skin. The paper does not compare their resemblance to human tissue with that of 2D cultures, so the claimed improvement over 2D cultures is unsupported. (LLM, conf=0.78)
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Untitled work
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Self-citation

Authors: Debels, H., Hamdi, M., Abberton, K., & Morrison, W.
Affiliations: Vrije Universiteit Brussel (BE)
Corresponding author: Debels, Heidi
Abberton, Keren
Morrison, Wayne
ORCID: Hamdi, Moustapha
Abberton, Keren
Morrison, Wayne
Venue: Plastic and Reconstructive Surgery Global Open
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2015-01
Volume: 3
Issue: 1
Pages: e284
ISSN: 2169-7574 (ISSN-L)
DOI: 10.1097/gox.0000000000000219
PMC: PMC4323388
OpenAlex: W1972634870
Cited by: 227
References: 107
Citations by year: 2026: 6 · 2025: 23 · 2024: 15 · 2023: 21 · 2022: 27 · 2021: 24 · 2020: 25 · 2019: 24 · 2018: 24 · 2017: 21 · 2016: 11 · 2015: 6
FWCI: 20.83
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc-nd
Locations: Plastic & Reconstructive Surgery Global Open (publishedVersion, cc-by-nc-nd)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Minerva Access (University of Melbourne) (submittedVersion)
VUBIR (Vrije Universiteit Brussel) (submittedVersion)
Topics: Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Health Sciences › Medicine › Surgery › Wound Healing and Treatments
Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
Keywords: dermal scaffolds, acellular scaffolds, skin graft alternatives, wound healing, dermal extracellular matrix, scaffold remodeling, biocompatibility, tissue engineering, reconstructive surgery

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Dermal Matrices and Bioengineered Skin Substitutes: A Critical Review of Current Options

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