The DOI matches its Crossref record; 130 of the 131 references it cites were found in a registry or an index.
Relationship of Spikes, Synaptic Activity, and Local Changes of Cerebral Blood Flow
Abstract
The coupling of electrical activity in the brain to changes in cerebral blood flow (CBF) is of interest because hemodynamic changes are used to track brain function. Recent studies, especially those investigating the cerebellar cortex, have shown that the spike rate in the principal target cell of a brain region (i.e. the efferent cell) does not affect vascular response amplitude. Subthreshold integrative synaptic processes trigger changes in the local microcirculation and local glucose consumption. The spatial specificity of the vascular response on the brain surface is limited because of the functional anatomy of the pial vessels. Within the cortex there is a characteristic laminar flow distribution, the largest changes of which are observed at the depth of maximal synaptic activity (i.e. layer IV) for an afferent input system. Under most conditions, increases in CBF are explained by activity in postsynaptic neurons, but presynaptic elements can contribute. Neurotransmitters do not mediate increases in CBF that are triggered by the concerted action of several second messenger molecules. It is important to distinguish between effective synaptic inhibition and deactivation that increase and decrease CBF and glucose consumption, respectively. In summary, hemodynamic changes evoked by neuronal activity depend on the afferent input function (i.e. all aspects of presynaptic and postsynaptic processing), but are totally independent of the efferent function (i.e., the spike rate of the same region). Thus, it is not possible to conclude whether the output level of activity of a region is increased based on brain maps that use blood-flow changes as markers.
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“These transactions are dependent on the particular features of different incoming stimuli, thus it is possible that the relevant neurovascular and neurometabolic counterparts are correspondingly distinct (Lauritzen, 2001).”
From Perception is associated with the brain’s metabolic response to sensory stimulation (2022) · cites this paper as Lauritzen, 2001
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Metadata
- Authors
- Lauritzen, M.
- Affiliations
- University of Copenhagen (DK)
- Corresponding author
- Lauritzen, Martin
- ORCID
- Lauritzen, Martin
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 2001-12
- Volume
- 21
- Issue
- 12
- Pages
- 1367-1383
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W2030025902
- Cited by
- 253
- References
- 131
- Citations by year
- 2026: 4 · 2025: 4 · 2023: 4 · 2022: 6 · 2021: 2 · 2020: 4 · 2019: 5 · 2018: 9 · 2017: 4 · 2016: 4 · 2015: 9 · 2014: 7 · 2013: 4 · 2012: 13
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- cerebral blood flow, neuronal activity, synaptic activity, hemodynamic coupling, spike frequency, cerebellar cortex, laminar blood flow, layer 4, postsynaptic neurons, presynaptic inhibition, glucose utilization, pial vessels, functional brain mapping
- MeSH terms
- Action Potentials, Animals, Brain, Cerebrovascular Circulation, Humans, Synaptic Transmission
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