Body fat distribution and left ventricular morphology and function in obese females
Abstract
OBJECTIVE: To study left ventricular function and morphology in non-hypertensive obese females and to relate the findings to body mass index (BMI) and to an index of body fat distribution (waist:hip ratio). DESIGN: Cross-sectional study. SETTING: Obesity unit in city hospital. SUBJECTS: Healthy obese females (n = 22) with BMI > 25 and < 40 kg/m2 and a non-obese, age-matched control group (n = 20) with BMI < 25 kg/m2. MAIN OUTCOME MEASURES: Blood pressure and non-invasive indices of left ventricular morphology and diastolic and systolic function. RESULTS: The obese group had significantly higher blood pressure, larger left ventricular end-diastolic diameter, greater left ventricular mass; larger left atrial size, signs of decreased left ventricular distensibility and prolonged left ventricular relaxation time index, and signs of supernormal systolic left ventricular function (as judged from the relationship between fractional shortening and end-systolic wall stress) than the non-obese controls. The results also indicated that left ventricular wall thickness and mass were well adapted to the increase in afterload, as judged by analyses of end-systolic wall tension and end-systolic wall stress. CONCLUSION: In confirmation of several previous studies, obesity was closely associated with an increase in blood pressure and left ventricular mass, and with early signs of disturbed left ventricular diastolic function. Left ventricular wall thickness and mass were well adapted to the increase in afterload; thus, we could not identify any non-afterload-dependent effect of an increase in BMI or waist:hip ratio on left ventricular hypertrophy.
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Many studies have shown increased LA dimensions in obese subjects compared with normal-weight control subjects.
“Many studies have shown increased LA dimensions in obese subjects compared with normal-weight control subjects (16, 17, 22, 140, 274, 371, 375).”
From Cardiac remodeling in obesity (2008) · cites this paper as [375]
LV ejection fraction is normal or even supranormal in the majority of obese subjects, even those with severe obesity.
“More recently, however, several studies have found that LV ejection fraction is normal or even supranormal in the majority of obese subjects, even those with severe obesity (22, 28, 155, 191, 242, 274, 279, 375, 377).”
From Cardiac remodeling in obesity (2008) · cites this paper as [375]
Prolongation of the isovolumic relaxation time is probably the most consistent diastolic abnormality seen in obesity.
“Prolongation of the isovolumic relaxation time is probably the most consistent diastolic abnormality seen in obesity (28, 242, 375).”
From Cardiac remodeling in obesity (2008) · cites this paper as [375]
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“266, 279, 377), and supernormal EF (28, 155, 274, 375) in obese subjects.”
BackgroundInfluentialMichele, M. D., Panico, S., Iannuzzi, A., Celentano, E., Ciardullo, A. V., Galasso, R., Sacchetti, L., Zarrilli, F., Bond, M. G., & Rubba, P. (2002) · Stroke · doi:10.1161/01.str.0000038989.90931.be · Cited by 212 · see citing works
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Lima‐Leopoldo, A. P., Leopoldo, A. S., da Silva, D. C. T., do Nascimento, A. F., de Campos, D. H. S., Luvizotto, R. D. A. M., de Deus, A. F., Freire, P. P., Medeiros, A., Okoshi, K., et al. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00088.2014 · Cited by 36 · see citing works
“According to some authors, IVRT prolongation is the most consistent diastolic abnormality observed in obese individuals (6, 41, 74).”
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“Prolongation of the isovolumic relaxation time also has been seen in obesity [7,11, 32 ].”
BackgroundHealth risks associated with obesity
Ali, A. T., & Crowther, N. J. (2005) · Journal of Endocrinology Metabolism and Diabetes of South Africa · doi:10.1080/22201009.2005.10872117 · Cited by 20 · see citing works
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BackgroundCardiac Structure and Function in Morbidly Obese Parturients: An Echocardiographic Study
Buddeberg, B. S., Fernandes, N. L., Vorster, A., Cupido, B. J., Lombard, C. J., Swanevelder, J. L., Girard, T., & Dyer, R. A. (2018) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000003554 · Cited by 8 · see citing works
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“Our findings corroborate previous studies demonstrating an association between obesity and LV dysfunction [10–12].”
ResultThe Relationship of Childhood Obesity with Cardiomyopathy and Heart Failure
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“Segundo alguns autores, (28,38,43) o prolongamento do TRIV é a mais consistente anorm alidade diastólica”
Background
- Authors
- Wikstrand, J., Pettersson, P., & Bj??rntorp, P.
- Affiliations
- Sahlgrenska University Hospital (SE)
- Venue
- Journal of Hypertension
- Published
- 1993-11
- Volume
- 11
- Issue
- 11
- Pages
- 1259???1266
- ISSN
- 0263-6352 (ISSN-L)
- OpenAlex
- W2055353618
- Cited by
- 17
- References
- 0
- Citations by year
- 2018: 1 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 2
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- obesity, left ventricular hypertrophy, left ventricular function, left ventricular diastolic function, body fat distribution, waist-to-hip ratio, body mass index, blood pressure, left ventricular mass, left ventricular wall thickness, end-systolic wall stress, afterload, left atrial size
- MeSH terms
- Adipose Tissue, Adult, Diastole, Female, Humans, Myocardial Contraction, Myocardium, Obesity, Multivariate Analysis, Ventricular Function, Left
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