Cited by 404Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

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THE FINE STRUCTURE OF NEUROFIBRILLARY TANGLES IN ALZHEIMERʼS DISEASE

Terry, Robert D.·1963·Journal of Neuropathology and Experimental Neurology

DOI 10.1097/00005072-196310000-00005

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Abstract

Robert D. Terry, M.D.; The Fine Structure of Neurofibrillary Tangles in Alzheimer's Disease*†‡, Journal of Neuropathology & Experimental Neurology, Volume

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Background
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“, twisted tubules (TT) (Terry, 1963; Hirano et al., 1968), and straight tubules (ST) (Hirano et al.”
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Shelanski, M. L., & Liem, R. K. H. (1979) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1979.tb11699.x · Cited by 63
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“Ultrastructural studies have also clearly pointed out their unique morphological features (Terry 1963; Kidd 1963).”
Background
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Tomlinson, B. E. (1982) · Psychological Medicine · doi:10.1017/s0033291700055549 · Cited by 64
“& Terry, R. D. (1974). Observations on axoplasmic transport in rabbits with aluminium induced neurofibrillary tangles.”
BackgroundMethodInfluential
Current and future implications of basic and translational research on amyloid-β peptide production and removal pathways
Böhm, C., Chen, F., Sévalle, J., Qamar, S., Dodd, R. B., Li, Y., Schmitt‐Ulms, G., Fraser, P. E., & George‐Hyslop, P. S. (2015) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2015.02.016 · Cited by 66
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Background
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Tanzi, R. E., George‐Hyslop, P. S., & Gusella, J. F. (1989) · Trends in Neurosciences · doi:10.1016/0166-2236(89)90055-6 · Cited by 61
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Self-citation
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Richards, S. J., Waters, J. J., Beyreuther, K. T., Masters, C. L., Wischik, C. M., Sparkman, D. R., White, C. L., Abraham, C. R., & Dunnett, S. B. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07950.x · Cited by 62
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Terry, R. D., & Wı́sniewski, H. M. (1972) · Advances in behavioral biology · doi:10.1007/978-1-4684-8503-5_7 · Cited by 64
Self-citation
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Rao, K. V. R., & Kielian, T. (2015) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12237 · Cited by 62
p44mpk MAP kinase induces aizheimer type alterations in tau function and in primary hippocampal neurons
Lu, Q., Soria, J., & Wood, J. G. (1993) · Journal of Neuroscience Research · doi:10.1002/jnr.490350411 · Cited by 56
Advances in Deep Neuropathological Phenotyping of Alzheimer Disease: Past, Present, and Future
Shakir, M., & Dugger, B. N. (2022) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlab122 · Cited by 58
Electron microscopic structure of the alzheimer's neurofibrillary changes in case of atypical senile dementia
Shibayama, H., & Kitoh, J. (1978) · Acta Neuropathologica · doi:10.1007/bf00690441 · Cited by 57
Type-2 alkenes mediate synaptotoxicity in neurodegenerative diseases
LoPachin, R. M., Gavin, T., & Barber, D. S. (2008) · NeuroToxicology · doi:10.1016/j.neuro.2008.04.016 · Cited by 53
CHEMISTRY OF THE FILAMENTS AND TUBULES OF BRAIN
Shelanski, M. L. (1973) · Journal of Histochemistry & Cytochemistry · doi:10.1177/21.6.529 · Cited by 57
Paired helical filaments in astrocytes: electron microscopy and immunohistochemistry in a case of atypical Alzheimer's disease
Nakano, I., Iwatsubo, T., Otsuka, N., Kamei, M., Matsumura, K., & Mannen, T. (1992) · Acta Neuropathologica · doi:10.1007/bf00296783 · Cited by 53
“clear demonstration of filaments in astrocytes which are indistinguishable from the constituents of neuronal NFTs, from both ultrastructural [6, 9, 10, 19 ] and immunohistochemi cal [4, 14, 15] viewpoints.”
Background
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Shen, X., Yu, J., Zhang, D., Xie, J., & Jiang, H. F. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-140153 · Cited by 52
“AD is characterized by the loss of neurons in the cognitive center and the presence of two separate pathological lesions, extracellular A plaques, and neurofibrillary tangles within neurons [1–6].”
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Yi, J. H., Park, H. J., Lee, S., Jung, J. W., Kim, B. C., Lee, Y. C., Ryu, J. H., & Kim, D. H. (2015) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2015.12.007 · Cited by 52
Argentophilic Plaques in Creutzfeldt-Jakob Disease
Hirano, A., Ghatak, N. R., Johnson, A. B., Partnow, M. J., & Gomori, A. J. (1972) · Archives of Neurology · doi:10.1001/archneur.1972.00490120070008 · Cited by 51
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Pedrioli, G., & Paganetti, P. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.595515 · Cited by 50
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Background
Excitotoxic mechanisms in the pathogenesis of dementia
Dodd, P. R., Scott, H. L., & Westphalen, R. I. (1994) · Neurochemistry International · doi:10.1016/0197-0186(94)90064-7 · Cited by 50
Twisted ribbon structure of paired helical filaments revealed by atomic force microscopy
Pollanen, M. S., Markiewicz, P., Bergeron, C., & Goh, M. C. (1994) · Neurobiology of Aging · doi:10.1016/0197-4580(94)92536-4 · Cited by 51
Neurofibrillary pathology: Current status and research perspectives
Wı́sniewski, H. M., & Soifer, D. (1979) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(79)90125-8 · Cited by 50
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Background
Chemical pathology of neurofibrils. Neurofibrillary tangles of Alzheimer's presenile-senile dementia.
Iqbal, K., Wı́sniewski, H. M., Grundke, I., Korthals, J. K., & Terry, R. D. (1975) · Journal of Histochemistry & Cytochemistry · doi:10.1177/23.7.1141687 · Cited by 49
“Terry (17), on the basis of the ultrastructural studies of these structures in”
BackgroundSelf-citation
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Savory, J., Ghribi, O., Forbes, M. S., & Herman, M. M. (2001) · Journal of Inorganic Biochemistry · doi:10.1016/s0162-0134(01)00309-9 · Cited by 49
Electron microscope studies of Schwann cells during the Wallerian degeneration with special reference to the cytoplasmic filaments
Bl�mcke, S., & Niedorf, H. R. (1966) · Acta Neuropathologica · doi:10.1007/bf00691081 · Cited by 49
Local and distant histopathological effects of unilateral amyloid-β 25–35 injections into the amygdala of young F344 rats
Sigurdsson, E. M., Lorens, S. A., Hejna, M. J., Dong, X.-W., & Lee, J. M. (1996) · Neurobiology of Aging · doi:10.1016/s0197-4580(96)00169-8 · Cited by 49
Immunological demonstration of tau protein in neurofibrillary tangles of Alzheimer's disease
Brion, J. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-9s321 · Cited by 55
“These filaments were described as paired helical filaments [60], twisted filaments or tubules [52,87,88].”
APP transgenesis: Approaches toward the development of animal models for Alzheimer disease neuropathology
Greenberg, B., Savage, M. J., Howland, D., Ali, S. M., Siedlak, S. L., Perry, G. L., Siman, R., & Scott, R. W. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(96)00001-2 · Cited by 45
Two Monoclonal Antibodies Recognize Alzheimer's Neurofibrillary Tangles, Neurofilament, and Microtubule‐Associated Proteins
Ksiezak‐Reding, H., & Yen, S. H. (1987) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1987.tb04114.x · Cited by 46
The Concept of Alzheimer's Disease and its Clinical Implications
Sourander, P., & Sjögren, H. (2008) · Novartis Foundation symposium · doi:10.1002/9780470719749.ch3 · Cited by 11
TREM2 analysis and increased risk of Alzheimer's disease
Finelli, D., Rollinson, S. J., Harris, J., Jones, M. S., Richardson, A. M. T., Gerhard, A., Snowden, J. S., Mann, D. M. A., & Pickering-Brown, S. M. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.08.001 · Cited by 45
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Background
Ultrastructure of neurofibrillary tangles in the cerebral cortex of sheep
Nelson, P. T., & Saper, C. B. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(94)00175-z · Cited by 45
Ultrastructure of capillary plaque-like degeneration in senile dementia
Miyakawa, T., Sumiyoshi, S., Murayama, E., & Deshimaru, M. (1974) · Acta Neuropathologica · doi:10.1007/bf00685258 · Cited by 45
Studies on the isolation and substructure of mammalian neurofilaments
Schlaepfer, W. W. (1977) · Journal of Ultrastructure Research · doi:10.1016/s0022-5320(77)80081-6 · Cited by 45
Neuropathologic differentiation of progressive supranuclear palsy and corticobasal degeneration
Dickson, D. W. (1999) · Journal of Neurology · doi:10.1007/pl00007746 · Cited by 42
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Zubenko, G. S. (1989) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/089198878900200102 · Cited by 42
Intranuclear aluminum accumulation in chronic animals with experimental neurofibrillary changes
Uemura, E. (1984) · Experimental Neurology · doi:10.1016/0014-4886(84)90155-9 · Cited by 42
Neurofilaments and microtubules in sensory neurons after peripheral nerve section
Zelen�, J. (1971) · Cell and Tissue Research · doi:10.1007/bf00330737 · Cited by 42
Paired helical filaments associated with Alzheimer disease are readily soluble structures
Rubenstein, R., Kascsak, R. J., MERZ, P. A., Wı́sniewski, H. M., Carp, R. I., & Iqbal, K. (1986) · Brain Research · doi:10.1016/0006-8993(86)91460-5 · Cited by 40
Distribution and ultrastructure of Alzheimer's neurofibrillary tangles in postencephalitic parkinsonism of Economo type
Ishii, T., & Nakamura, Y. (1981) · Acta Neuropathologica · doi:10.1007/bf00691532 · Cited by 39
“ANT in the brains of patients with Alzheimer's disease, senile dementia (Terry 1963) or postencephalitic parkinsonism (Wisniewski et al.”
Background
Caenorhabditis elegans models of tauopathy
Pir, G. J., Choudhary, B. C., & Mandelkow�, E. (2017) · The FASEB Journal · doi:10.1096/fj.201701007 · Cited by 39
“Tauopathies are characterized by the intracellular accumulation of paired helical filaments (PHFs) (1, 2), composedmainly of post-translationally modified tau (3).”
Background
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Cancilla, P. A., & Barlow, R. M. (1966) · Acta Neuropathologica · doi:10.1007/bf00687855 · Cited by 39
Allgemeine morphologische Pathologie des Nervengewebes
Hager, H. (1968) · Handbuch der allgemeinen Pathologie · doi:10.1007/978-3-642-86325-7_1 · Cited by 38
What is Alzheimer's disease? An analysis of nosological perspectives from the 20th and 21st centuries
Villain, N., & Michalon, R. (2024) · European Journal of Neurology · doi:10.1111/ene.16302 · Cited by 43
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Gelman, S., Palma, J. D., Tombaugh, G. C., & Ghavami, A. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170457 · Cited by 36
“Pathologically, AD is characterized by formation and accumulation of extracellular amyloid plaques and intracellular neurofibrillary tangles (NFTs) in cortical and sub-cortical brain regions [3, 4].”
Background
Association of TLR4 with Alzheimer's disease risk and presymptomatic biomarkers of inflammation
Miron, J., Picard, C., Lafaille‐Magnan, M., Savard, M., Labonté, A., Breitner, J. C. S., Rosa‐Neto, P., Auld, D. S., & Poirier, J. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2019.03.012 · Cited by 37
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Sasaki, S., & Maruyama, S. (1994) · Acta Neuropathologica · doi:10.1007/bf00293318 · Cited by 37
“The constricted fllaments are similar to the paired helical filaments seen in spinal ganglion neurons of senescent rats [23] and to the paired filaments found in the dendritic terminals of the cerebral cortex in aged rhesus monkeys [24], but differ f rom the neurofibrillary tangles seen in Alzheimer's disease [21].”
Background
Effect of Maturation and Aging on the Rate of Fast Axoplasmic Transport in Mammalian Nerve
Ochs, S. (1973) · Progress in brain research · doi:10.1016/s0079-6123(08)60699-8 · Cited by 37
Dementia of alzheimer type (DAT) — a review of its morbid anatomy
ULRICH, J., Probst, A., Anderton, B. H., & Kahn, J. (1986) · Journal of Molecular Medicine · doi:10.1007/bf01732633 · Cited by 38
“Furthermore, amyloid, astrocytic processes, microglia and macrophages can be observed within them (Kidd 1964; Gonatas et al. 1967; Krigman et al. 1965; Terry 1963; Terry et al. 1964; Wisniewski et al. 1972).”
Intracytoplasmic Acidophilic Granules in the Substantia Nigra
Schochet, S. S. (1970) · Archives of Neurology · doi:10.1001/archneur.1970.00480240070010 · Cited by 36
Ultrastructure of anterior horn motor neurones in the Hirano-Kurland-Sayre type of combined neurological system degeneration
Hughes, J. T., & Jerrome, D. W. (1971) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(71)90002-5 · Cited by 36
Neoplasms of mixed mesenchymal and neuroepithelial type With consideration of the relationship between meningioma and neurilemmoma
Shuangshotĭ, S., Netsky, M. G., & Jane, J. A. (1971) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(71)90217-6 · Cited by 35
SUBUNIT STRUCTURE OF THE ALZHEIMER TANGLE
Wischik, C. M., & Crowther, R. A. (1986) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a072098 · Cited by 35
Studies in Ageing of the Brain
Nikaido, T. (1971) · Archives of Neurology · doi:10.1001/archneur.1971.00490030024002 · Cited by 35
Presenilin Binding Protein Is Associated with Neurofibrillary Alterations in Alzheimer’s Disease and Stimulates Tau Phosphorylation
Chen, Q., Yoshida, H., Schubert, D., Maher, P. A., Mallory, M. E., & Masliah, E. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63005-2 · Cited by 33
A neurologist's view of Alzheimer's disease and dementia
Katzman, R. (2004) · International Psychogeriatrics · doi:10.1017/s1041610204000456 · Cited by 36
“The application of the electron microscope to tissue from the brains of patients with AD led to the independent discovery of the ultrastructure of the neurofibrillary tangle by Kidd (1963) in Great Britain and Terry (1963) in the U.S.A.”
Method
Tau; One Protein, So Many Diseases
Tabeshmehr, P., & Eftekharpour, E. (2023) · Biology · doi:10.3390/biology12020244 · Cited by 33
“These studies showed that NFTs are predominantly composed of insoluble fibers called paired helical filaments (PHFs) [33].”
Background
Linking molecular motors to Alzheimer’s disease
Stokin, G. B., & Goldstein, L. S. B. (2006) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2005.12.085 · Cited by 32
Widespread distribution of tau in the astrocytic elements of glial tumors
Miyazono, M., Iwaki, T., Kitamoto, T., Shin, R., Fukui, M., & Tateishi, J. (1993) · Acta Neuropathologica · doi:10.1007/bf00304137 · Cited by 32
“Paired helical filaments (PHF), which form neurofibrillary tangles (NFTs) in neuronal perikaryon and in dystrophic neurites, are the most characteristic cytoskeletal alteration affecting numerous neurons in Alzheimer's disease (AD) [14, 30 ].”
Background
A human ganglioglioma containing paired helical filaments
Oberc-Greenwood, M. A., McKeever, P. E., Kornblith, P. L., & Smith, B. H. (1984) · Human Pathology · doi:10.1016/s0046-8177(84)80144-6 · Cited by 33
Neurofibrillary tangles in the dentate granule cells of patients with Alzheimer's disease, Lewy body disease and progressive supranuclear palsy
Wakabayashi, K., Hansen, L. A., Vincent, I. J., Mallory, M. E., & Masliah, E. (1997) · Acta Neuropathologica · doi:10.1007/s004010050576 · Cited by 33
“In AD, the NFTs are usually composed of twisted tubules [27, 46 , 47].”
Background
Ultrastructure of a regular arrangement of microtubules and neurofilaments
Bertolini, B., Monaco, G., & Rossi, A. (1970) · Journal of Ultrastructure Research · doi:10.1016/s0022-5320(70)90124-3 · Cited by 33
A Novel Perspective on Tau in Alzheimers Disease
Bonda, D., Castellani, R. J., Zhu, X., Nunomura, A., Lee, H., Perry, G. L., & Smith, M. A. (2011) · Current Alzheimer Research · doi:10.2174/156720511796717131 · Cited by 32
“The structure of the neurofibrillary tangle (NFT), a hallmark pathology of Alzheimer disease (AD), was first illuminated by Kidd and Terry in 1963 [1,2], with Kidd describing paired helical filaments (PHF).”
Background
Gut Inflammation Induced by Dextran Sulfate Sodium Exacerbates Amyloid-β Plaque Deposition in the App NL – G – F Mouse Model of Alzheimer’s Disease
Sohrabi, M., Pecoraro, H. L., & Combs, C. K. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201099 · Cited by 31
Alzheimer neurofibrillary tangles contain 2.1 nm filaments structurally identical to the microtubule-associated protein τ: a high-resolution transmission electron microscope study of tangles and senile plaque core amyloid
Ruben, G. C., Iqbal, K., Wisniewski, H. M., Johnson, J. E., & Grundke, I. (1992) · Brain Research · doi:10.1016/0006-8993(92)91092-s · Cited by 32
Neuronal Inclusions
Schochet, S. S. (1972) · Elsevier eBooks · doi:10.1016/b978-0-12-119284-6.50009-9 · Cited by 40
Ultra-structure des corps de lafora
Toga, M., Dubois, D., & Hassoun, J. (1968) · Acta Neuropathologica · doi:10.1007/bf00691307 · Cited by 32
Quantitative studies of neuronal RNA on the subiculum of demented old individuals
Uemura, E., & Hartmann, H. A. (1979) · Brain Research Bulletin · doi:10.1016/s0361-9230(79)80005-2 · Cited by 30
Neuropathological and Neurochemical Aspects of Alzheimer’s Disease
Mann, D. M. A. (1988) · Springer eBooks · doi:10.1007/978-1-4613-0933-8_1 · Cited by 31
Structural changes of central nervous system in swayback (Enzootic Ataxia) of lambs
Cancilla, P. A., & Barlow, R. M. (1966) · Acta Neuropathologica · doi:10.1007/bf00687856 · Cited by 31
The Pathology of the Central Myelinated Axon
Hirano, A. (1972) · Elsevier eBooks · doi:10.1016/b978-0-12-119285-3.50009-x · Cited by 32
Progressive Supranuclear Palsy and Corticobasal Degeneration
Coughlin, D. G., Dickson, D. W., Josephs, K. A., & Litvan, I. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-51140-1_11 · Cited by 33
Pathogenesis of Alzheimer’s Disease and Diversity of 1,2,3-Triazole Scaffold in Drug Development: Design Strategies, Structural Insights, and Therapeutic Potential
Singh, A., Singh, K., Kaur, J., Kaur, R., Sharma, A., Kaur, J., Kaur, U., Chadha, R., & Bedi, P. M. S. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00393 · Cited by 30
Hippocampal sclerosis with four-repeat tau-positive round inclusions in the dentate gyrus: a new type of four-repeat tauopathy
Miki, Y., Mori, F., Hori, E., Kaimori, M., & Wakabayashi, K. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0531-2 · Cited by 29
“neurofibrillary tangles in the cerebral cortex in mixed 3R/4R tauopathy (AD) are composed of twisted tubules [35], those in the dentate granule cells are mainly composed of straight tubules [10, 22, 38].”
Background
Effects of ginseol k-g3, an Rg3-enriched fraction, on scopolamine-induced memory impairment and learning deficit in mice
Peña, I. D., Yoon, S. Y., Kim, H. J., Park, S., Hong, E. Y., Ryu, J. H., Park, I. H., & Cheong, J. H. (2014) · Journal of Ginseng Research · doi:10.1016/j.jgr.2013.11.003 · Cited by 30
“Alzheimer’s disease (AD), the most common age-related neurodegenerative disorder [1], is characterized by the formation of neurofibrillary tangles in the medial temporal lobe and cortical areas of the brain [2] and senile plaques [3].”
Background
Extracellular matrix (extracellular components)
Ghadially, F. N. (1988) · Elsevier eBooks · doi:10.1016/b978-0-407-01572-2.50018-6 · Cited by 30
Neurofibrillary Pathology: An Update
Iqbal, K., Wı́sniewski, H. M., Grundke, I., & Terry, R. D. (1977) · Advances in behavioral biology · doi:10.1007/978-1-4684-3093-6_13 · Cited by 33
Self-citation
Cytomorphological Alterations in the Aging Animal Brain with Emphasis on Golgi Studies
Mervis, R. F. (1981) · Springer eBooks · doi:10.1007/978-1-4684-3929-8_4 · Cited by 31
Experimental neurofibrillary degeneration and altered electrical activity
Crapper, D. R. (1973) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(73)90211-3 · Cited by 30
Effects of aryl methanesulfonate derivatives on acetylcholinesterase and butyrylcholinesterase
Zilbeyaz, K., Stellenboom, N., Güney, M., Öztekіn, A., & Şentürk, M. (2018) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22210 · Cited by 29
Filaments and Tubules in the Nervous System
Shelanski, M. L., & Feit, H. (1972) · Elsevier eBooks · doi:10.1016/b978-0-12-119286-0.50008-9 · Cited by 29
Immune system‐associated antigens on the surface of peripheral blood lymphocytes in patients with Alzheimer's disease
Ikeda, T., Yamamoto, K., Takahashi, K., & Yamada, M. (1991) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1991.tb05573.x · Cited by 28
“Recent studies have focused mainly on these lesions and achieved encouraging results : the presence of p proteins in apposition to senile plaques was demonstrated (1) and paired helical filaments (PHF) were shown to be present in neurofibrillary changes (2, 3).”
Background
Structural insights into Alzheimer filament assembly pathways based on site‐directed mutagenesis and S‐glutathionylation of three‐repeat neuronal Tau protein
Noto, L. D., Deture, M. A., & Purich, D. L. (2005) · Microscopy Research and Technique · doi:10.1002/jemt.20195 · Cited by 28
Building a Mystery: Alzheimer's Disease, Mild Cognitive Impairment, and Beyond
Gaines, A. D., & Whitehouse, P. J. (2006) · Philosophy, psychiatry & psychology · doi:10.1353/ppp.2006.0037 · Cited by 27
Tau-related protein present in paired helical filaments has a decreased tubulin binding capacity as compared with microtubule-associated protein tau
Nieto, A., Correas, I., López-Otı́n, C., & Ávila, J. (1991) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(91)90005-t · Cited by 27
General Introduction and a Brief History of Amyloidosis
Cohen, A. S. (1986) · Springer eBooks · doi:10.1007/978-94-009-4309-4_1 · Cited by 27
Role of Apolipoprotein E in Alzheimer’s Disease
Zannis, V. I., Zanni, E. E., Makrides, S. C., Kardassis, D., & Aleshkov, S. B. (1998) · Springer eBooks · doi:10.1007/978-1-4899-0133-0_13 · Cited by 26
Dietary phytochemicals: As a potential natural source for treatment of Alzheimer's Disease
Ren, Z., Yang, H., Zhu, C., Fan, D., & Deng, J. (2023) · Food Innovation and Advances · doi:10.48130/fia-2023-0007 · Cited by 27
Demonstration of β amyloid protein‐containing neurofibrillary tangles in parkinsonism‐dementia complex on Guam
Ito, H., Hirano, A., Yen, S. H., & Kato, S. (1991) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1991.tb00736.x · Cited by 25
Paired helical filaments in corticobasal degeneration: the fine fibrillary structure with NanoVan
Tracz, E., Dickson, D. W., Hainfeld, J. F., & Ksiȩżak-Reding, H. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00830-5 · Cited by 26

Authors: Terry, R. D.
Corresponding author: Terry, Robert D.
Venue: Journal of Neuropathology and Experimental Neurology
Publisher: Oxford University Press (OUP)
Published: 1963-10
Volume: 22
Issue: 4
Pages: 629-642
ISSN: 0022-3069 (ISSN-L)
DOI: 10.1097/00005072-196310000-00005
OpenAlex: W2070494722
Cited by: 403
References: 0
Citations by year: 2026: 4 · 2025: 5 · 2024: 6 · 2023: 8 · 2022: 10 · 2021: 9 · 2020: 13 · 2019: 10 · 2018: 6 · 2017: 8 · 2016: 3 · 2015: 7 · 2014: 10 · 2013: 4 · 2012: 6
FWCI: 3.13
Type: journal article
Language: en
Open access: closed
Locations: Journal of Neuropathology & Experimental Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: neurofibrillary tangles, Alzheimer's disease, fine structure, ultrastructure, neurofibrillary pathology
MeSH terms: Alzheimer Disease, Cerebral Cortex, Dementia, Electrons, Humans, Microscopy, Microscopy, Electron, Neurons, Pathology, Psychotic Disorders, Neurofibrillary Tangles

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THE FINE STRUCTURE OF NEUROFIBRILLARY TANGLES IN ALZHEIMERʼS DISEASE

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