Cited by 404Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

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THE FINE STRUCTURE OF NEUROFIBRILLARY TANGLES IN ALZHEIMERʼS DISEASE

Terry, Robert D.·1963·Journal of Neuropathology and Experimental Neurology

DOI 10.1097/00005072-196310000-00005

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Abstract

Robert D. Terry, M.D.; The Fine Structure of Neurofibrillary Tangles in Alzheimer's Disease*†‡, Journal of Neuropathology & Experimental Neurology, Volume

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S100B Inhibitor Pentamidine Attenuates Reactive Gliosis and Reduces Neuronal Loss in a Mouse Model of Alzheimer’s Disease
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“Alzheimer’s disease (AD) is the most common age-related neurodegenerative disorder [1], whose pathologic hallmarks are the deposit of neurofibrillary tangles and senile plaques (beta-amyloid protein deposits) in the brain [2, 3].”
Background
Immunological and conformational characterization of a phosphorylated immunodominant epitope on the paired helical filaments found in Alzheimer's disease
Láng, E., Szendrei, G. I., Lee, V. M. ‐., & Ötvös, L. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)91264-q · Cited by 86
Aβ oligomers inhibit synapse remodelling necessary for memory consolidation
Freir, D. B., Fedriani, R., Scully, D., Smith, I. M., Selkoe, D. J., Walsh, D. M., & Regan, C. M. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.01.001 · Cited by 85
A Reexamination of Aluminum in Alzheimer's Disease: Analysis by Energy Dispersive X-ray Microprobe and Flameless Atomic Absorption Spectrophotometry
Jacobs, R. W., Duong, T., Jones, R. E., Trapp, G. A., & Scheibel, A. B. (1989) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100029838 · Cited by 84
Current directions in tau research: Highlights from Tau 2020
Sexton, C. E., Snyder, H. M., Beher, D., Boxer, A. L., Brannelly, P., Brion, J., Buée, L., Cacace, A. M., Chételat, G., Citron, M., et al. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12452 · Cited by 89
Bilateral Injections of Amyloid-β 25-35 into the Amygdala of Young Fischer Rats: Behavioral, Neurochemical, and Time Dependent Histopathological Effects
Sigurdsson, E. M., Lee, J. M., Dong, X.-W., Hejna, M. J., & Lorens, S. A. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00154-1 · Cited by 81
The Aging Process
Geokas, M. C., Lakatta, E. G., Makinodan, T., et al. (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-113-6-455 · Cited by 78
Immunocytochemistry of neurofibrillary tangles with antibodies to subregions of tau protein: identification of hidden and cleaved tau epitopes and a new phosphorylation site
Dickson, D. W., Ksiȩżak-Reding, H., Liu, W.-K., Davies, P., Crowe, A., & Yen, S. H. (1992) · Acta Neuropathologica · doi:10.1007/bf00227736 · Cited by 77
“At the electron microscopic level, NFT are composed predominantly of 22-nrn diameter paired helical filaments (PHF) with a variable number of admixed 15- to 18-nm diameter straight filaments (SF), as well as granular material [42, 47].”
Background
The ultrastructural localization of sulfated proteoglycans is identical in the amyloids of Alzheimer's disease and AA, AL, senile cardiac and medullary carcinoma-associated amyloidosis
Young, I. D., Willmer, J., & Kisilevsky, R. (1989) · Acta Neuropathologica · doi:10.1007/bf00688210 · Cited by 75
“They possess the same tinctorial characteristics as neuritic plaque and cerebrovascular amyloid but ultrastructurally are composed of bundles of 10- to 20-nm paired filaments which are typically helically wound [42, 51 , 61] but which may assume a straight configuration [35].”
Background
Characterization of tau fibrillization in vitro
Xu, S., Brunden, K. R., Trojanowski, J. Q., & Lee, V. M. ‐. (2010) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2009.06.002 · Cited by 81
The Seed Extract of Cassia obtusifolia Offers Neuroprotection to Mouse Hippocampal Cultures
Drever, B. D., Anderson, W. G. L., Riedel, G., Kim, D. H., Ryu, J. H., Choi, D.-Y., & Platt, B. (2008) · Journal of Pharmacological Sciences · doi:10.1254/jphs.08034fp · Cited by 74
Spongiform alterations in brain biopsies of presenile dementia
Flament-Durand, J., & Couck, A. M. (1979) · Acta Neuropathologica · doi:10.1007/bf00684819 · Cited by 73
“The fine structure o f the lesions we observed were otherwise typical o f presenile dementia and corresponded to the previous descriptions (Terry, 1963,1976; Wisniewski et al., 1964; Terry and Wisniewski , 1970). Hi rano bodies observed in one o f the specimens are identical to those described by Hi rano et al. (1968)…”
Result
Amyloid precursor protein-induced axonopathies are independent of amyloid-β peptides
Stokin, G. B., Almenar-Queralt, A., Gunawardena, S., Rodrigues, E. M., Falzone, T., Kim, J., Lillo, C., Mount, S. L., Roberts, E. A., McGowan, E., et al. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn240 · Cited by 72

Authors: Terry, R. D.
Corresponding author: Terry, Robert D.
Venue: Journal of Neuropathology and Experimental Neurology
Publisher: Oxford University Press (OUP)
Published: 1963-10
Volume: 22
Issue: 4
Pages: 629-642
ISSN: 0022-3069 (ISSN-L)
DOI: 10.1097/00005072-196310000-00005
OpenAlex: W2070494722
Cited by: 403
References: 0
Citations by year: 2026: 4 · 2025: 5 · 2024: 6 · 2023: 8 · 2022: 10 · 2021: 9 · 2020: 13 · 2019: 10 · 2018: 6 · 2017: 8 · 2016: 3 · 2015: 7 · 2014: 10 · 2013: 4 · 2012: 6
FWCI: 3.13
Type: journal article
Language: en
Open access: closed
Locations: Journal of Neuropathology & Experimental Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: neurofibrillary tangles, Alzheimer's disease, fine structure, ultrastructure, neurofibrillary pathology
MeSH terms: Alzheimer Disease, Cerebral Cortex, Dementia, Electrons, Humans, Microscopy, Microscopy, Electron, Neurons, Pathology, Psychotic Disorders, Neurofibrillary Tangles

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THE FINE STRUCTURE OF NEUROFIBRILLARY TANGLES IN ALZHEIMERʼS DISEASE

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