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Neurons May Live for Decades with Neurofibrillary Tangles
Abstract
Neurons containing neurofibrillary tangles (NFT) are one of the pathological hallmarks of Alzheimer disease (AD). It is known that this population of neurons express gene products and thus function to some degree, but it is unknown how long these neurons may survive with NFT. It is also thought that the formation of NFT results in the death of neurons. Using quantitative data on neuron loss and NFT formation as a function of disease duration, we have generated a computer program that models both the degeneration of CA1 hippocampal neurons and the formation of NFT in these neurons in AD. Modeling various neuron survival times with NFT and altering selected assumptions upon which the models are based, we arrive at the conclusions that 1) CA1 hippocampal neurons survive with NFT for about 20 years, and 2) NFT may not be obligatory for death of CA1 hippocampal neurons in AD.
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“NFT‐containing neurons can survive for decades, 7 , 8 indicating that NFTs are neither obligatory nor sufficient to induce neuronal dysfunction and toxicity.”
From Senescence, brain inflammation, and oligomeric tau drive cognitive decline in Alzheimer's disease: Evidence from clinical and preclinical studies (2024) · cites this paper as [8]
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Metadata
- Authors
- Morsch, R., Simon, W., & Coleman, P. D.
- Affiliations
- University of Rochester Medicine (US)
- Venue
- Journal of Neuropathology and Experimental Neurology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-02
- Volume
- 58
- Issue
- 2
- Pages
- 188-197
- ISSN
- 0022-3069 (ISSN-L)
- OpenAlex
- W2018983416
- Cited by
- 370
- References
- 0
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 12 · 2023: 16 · 2022: 11 · 2021: 9 · 2020: 19 · 2019: 10 · 2018: 15 · 2017: 13 · 2016: 12 · 2015: 18 · 2014: 19 · 2013: 13 · 2012: 15
- FWCI
- 7.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuropathology & Experimental Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r35ag009016-07, 5r01ag014441-05)
- National Institute on Aging (AG 08665, AG09016, R01 AG14441, P30AG008665)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- neurofibrillary tangles, Alzheimer's disease, neuronal survival, CA1 hippocampal neurons, neurodegeneration, neuronal loss, disease duration, computational modeling, neuronal cell death
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Cell Count, Cell Survival, Hippocampus, Humans, Middle Aged, Neurons, Neurofibrillary Tangles, Cellular Senescence, Disease Progression
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