Neuron loss from the hippocampus of Alzheimer's disease exceeds extracellular neurofibrillary tangle formation

Kril, Jillian; Patel, Smita; Harding, Antony; Halliday, Glenda

doi:10.1007/s00401-001-0477-5

Cited by 190Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

Neuron loss from the hippocampus of Alzheimer's disease exceeds extracellular neurofibrillary tangle formation

Kril, Jillian, Patel, Smita, Harding, Antony, Halliday, Glenda·2002·Acta Neuropathologica

DOI 10.1007/s00401-001-0477-5

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Abstract

Neurofibrillary tangle (NFT) formation in the CA1 region of the hippocampus is one of the early events in the pathogenesis of Alzheimer's disease (AD). As the disease progresses more NFTs form and there is substantial neuron loss. In this study we investigated whether NFT formation accounts for all the CA1 pyramidal neuron loss seen in AD. Using unbiased stereological techniques, we estimated the total number of neurons and the number of intra- and extra-cellular NFTs in the hippocampus of 10 patients with AD and 10 age-matched controls. Marked neuronal loss (approximately 60%) was identified in AD, although NFTs accounted for only a small proportion of this loss (2.2-17.2%, mean 8.1%). Analysis of NFT accumulation with duration of dementia showed a linear relationship, supporting the belief that NFTs progressively accumulate with time.

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Some, but not all, studies indicate that more neurons disappear in brains of demented subjects than can be explained directly by the number of neurofibrillary tangles and ghost tangles observed at autopsy.
“Some, but not all, studies have indicated that more neurons disappear in brains of demented subjects than can be explained directly by the number of NFTs and “ghost tangles” observed at autopsy (285, 304, 307-310) (but see [305]).”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [307]

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Authors: Kril, J., Patel, S., Harding, A., & Halliday, G.
Affiliations: The University of Sydney (AU)
Neuroscience Research Australia (AU)
Corresponding author: Kril, Jillian
ORCID: Kril, Jillian
Patel, Smita
Halliday, Glenda
Venue: Acta Neuropathologica
Publisher: Springer Science and Business Media LLC
Published: 2002-04-01
Volume: 103
Issue: 4
Pages: 370-376
ISSN: 0001-6322 (ISSN-L)
1432-0533
DOI: 10.1007/s00401-001-0477-5
OpenAlex: W2029462234
Cited by: 190
References: 58
Citations by year: 2026: 5 · 2025: 8 · 2024: 8 · 2023: 6 · 2022: 8 · 2021: 5 · 2020: 7 · 2019: 6 · 2018: 6 · 2017: 5 · 2016: 7 · 2015: 8 · 2014: 8 · 2013: 8 · 2012: 6
FWCI: 5.59
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Acta Neuropathologica (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: Alzheimer's disease, neurofibrillary tangles, hippocampal CA1, neuronal loss, pyramidal neurons, stereology
MeSH terms: Alzheimer Disease, Extracellular Space, Female, Hippocampus, Humans, Male, Neurons, Reference Values, Time Factors, Neurofibrillary Tangles

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Neuron loss from the hippocampus of Alzheimer's disease exceeds extracellular neurofibrillary tangle formation

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