Twenty-Four Hour Antihypertensive Efficacy of Indapamide, 1.5-Mg Sustained Release: Results of Two Randomized Double-Blind Controlled Studies
Abstract
The antihypertensive efficacy of a 1.5-mg sustained-release formulation (SR 1.5) of indapamide, a diuretic related to thiazide, has been pointed out by using conventional sphygmomanometric measurement 24 h after dosing in clinic, in two large European randomized, double-blind, controlled studies (2 and 3 months). One of these studies was then extended to 12 months, as a complementary open study. Quality-controlled ambulatory blood pressure monitoring (ABPM) data for a total of 216 patients from these studies are presented, including subgroups of hypertensives and responders. Indapamide SR 1.5 achieves an adequate 24-h blood pressure control by significantly reducing the 24-h, diurnal, and nocturnal blood pressures versus baseline, confirming the sphygmomanometric data. The benefit at 2 and 3 months is maintained at 1 year, which confirms the long-term efficacy of SR 1.5 mg. The trough-to-peak ratio--not previously calculated for a diuretic according to international guidelines--meets Food and Drug Administration requirements and confirms the 24-h efficacy of indapamide SR 1.5.
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Minimum plasma concentration of sustained release indapamide at 1.5 mg/d was similar to 2.5 mg/d conventional formulation.
“The minimum plasma concentration obtained with the sustained release formulation of indapamide at the dosage of 1.5 mg/d was similar to that obtained with 2.5 mg/d of conventional drug formulation.144”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [144]
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Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles
Singh, A. P., Biswas, A., Shukla, A., & Maiti, P. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0068-3 · Cited by 645 · see citing works
- Authors
- Mallion, J.-M., Asmar, R., Boutelant, S., & Guez, D.
- Affiliations
- Centre Hospitalier Universitaire de Grenoble (FR)
- Corresponding author
- Guez, David
- Venue
- Journal of Cardiovascular Pharmacology
- Published
- 1998-10
- Volume
- 32
- Issue
- 4
- Pages
- 673-678
- ISSN
- 0160-2446 (ISSN-L)
- OpenAlex
- W2320651688
- Cited by
- 32
- References
- 28
- Citations by year
- 2026: 4 · 2019: 1 · 2016: 2 · 2014: 1 · 2012: 3
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cardiovascular Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- indapamide, sustained-release formulation, hypertension, antihypertensive efficacy, ambulatory blood pressure monitoring, trough-to-peak ratio, thiazide-like diuretics, nocturnal blood pressure, long-term efficacy, blood pressure control
- MeSH terms
- Adolescent, Adult, Aged, Antihypertensive Agents, Blood Pressure, Circadian Rhythm, Delayed-Action Preparations, Diuretics, Double-Blind Method, Europe, Female, Humans, Hypertension, Indapamide, Male, Middle Aged, Blood Pressure Monitoring, Ambulatory
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