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Influence of a Total Parenteral Nutrition Enriched with omega-3 Fatty Acids on Leukotriene Synthesis of Peripheral Leukocytes and Systemic Cytokine Levels in Patients with Major Surgery
Abstract
OBJECTIVE: Nutritive immunomodulation of patients after major surgery. DESIGN: Prospective, randomized controlled double-blind study. PATIENTS: Forty patients undergoing major intestinal surgery. Patients were divided into two groups: one received a total parenteral nutrition enriched with omega-3 fatty acids for 5 days postoperatively, the other an isocaloric, control nutrition. MATERIALS AND METHODS: We analyzed the leukocyte ability to release leukotrienes from whole blood leukocytes stimulated with the calcium ionophore A23187 (5 micromol/L) by reverse phase high-performance liquid chromatography and circulating cytokines by enzyme-linked immunosorbent assay. RESULTS: Leukocytes from patients of the omega-3 fatty acids group generated significantly higher amounts of less biologically active leukotriene B5 as compared to the control group (p < or = 0.001). This was accompanied by a significant decrease in the generation of proinflammatory leukotriene B4 (p < or = 0.006) in the study group. In contrast to interleukin-1beta, interleukin-6, and interleukin-10 systemic levels of tumor necrosis factor-alpha (p < or = 0.05) were postoperatively decreased in the study group. CONCLUSION: Our data provide evidence that a total parenteral nutrition enriched with omega-3 fatty acids modulates the lipid mediator pattern and systemic tumor necrosis factor-alpha levels.
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Cited by
ESPEN guidelines on parenteral nutrition: intensive care
Singer, P., Berger, M. M., Van den Berghe, G., Biolo, G., Calder, P., Forbes, A., Griffiths, R., Kreyman, G., Leverve, X., & Pichard, C. (2009) · Clinical Nutrition · doi:10.1016/j.clnu.2009.04.024 · Cited by 1,907
Polyunsaturated fatty acids, inflammation, and immunity
Calder, P. C. (2001) · Lipids · doi:10.1007/s11745-001-0812-7 · Cited by 784
Polyunsaturated fatty acids, inflammation and immunity
Calder, P., & Grimble, R. (2002) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601478 · Cited by 729
Dietary modification of inflammation with lipids
Calder, P. C. (2002) · Proceedings of the Nutrition Society · doi:10.1079/pns2002166 · Cited by 485
Immune modulation by parenteral lipid emulsions
Wanten, G. J., & Calder, P. C. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.5.1171 · Cited by 416
Metadata
- Authors
- Wachtler, P., Konig, W., Senkal, M., Kemen, M., & Koller, M.
- Venue
- The Journal of Trauma: Injury, Infection, and Critical Care
- Published
- 1997-02
- Volume
- 42
- Issue
- 2
- Pages
- 191-198
- ISSN
- 1079-6061
- OpenAlex
- W1993628230
- Cited by
- 161
- References
- 0
- FWCI
- 8.14
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Influence of a Total Parenteral Nutrition Enriched with omega-3 Fatty Acids on Leukotriene Synthesis of Peripheral Leukocytes and Systemic Cytokine Levels in Patients with Major Surgery. https://app.cochat.ai/papers/10.1097/00005373-199702000-00004
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- Wachtler, P., Konig, W., Senkal, M., Kemen, M., & Koller, M. (1997). Influence of a Total Parenteral Nutrition Enriched with omega-3 Fatty Acids on Leukotriene Synthesis of Peripheral Leukocytes and Systemic Cytokine Levels in Patients with Major Surgery. The Journal of Trauma: Injury, Infection, and Critical Care. https://doi.org/10.1097/00005373-199702000-00004
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
