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Age-related decline in physical activity: generalization to nonhumans
Abstract
The question of whether the age-related decline in physical activity reported in humans has a biological basis is addressed by reviewing gerontological studies that have used nonhuman subjects. From at least three separate arguments, this review provides strong support for a biological basis of this phenomenon. First, age-related decline in activity measured in many different ways is observed across a wide range of nonhuman species. Second, the activity decline appears predictive of lifespan. Increased levels of activity predict longevity, and increasing activity through exercise increases median lifespan. Third, activity declines appear related to altered neurotransmission involving the central dopamine system. Reduced dopamine release or loss of dopamine receptors appears to underlie age-related activity decline, and interventions that enhance dopamine function can increase activity levels in aged animals.
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Cited by
Global physical activity levels: surveillance progress, pitfalls, and prospects
Hallal, P. C., Andersen, L. B., Bull, F. C., Guthold, R., Haskell, W., & Ekelund, U. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60646-1 · Cited by 5,711
Correlates of physical activity: why are some people physically active and others not?
Bauman, A. E., Reis, R. S., Sallis, J. F., Wells, J. C., Loos, R. J., & Martin, B. W. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60735-1 · Cited by 4,151
Sarcopenia: Aging-Related Loss of Muscle Mass and Function
Larsson, L., Degens, H., Li, M., Salviati, L., Lee, Y. I., Thompson, W., Kirkland, J. L., & Sandri, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00061.2017 · Cited by 1,797
Physical activity change during adolescence: a systematic review and a pooled analysis
Dumith, S. C., Gigante, D. P., Domingues, M. R., & Kohl, H. W. (2011) · International Journal of Epidemiology · doi:10.1093/ije/dyq272 · Cited by 1,275
Dishman, R. K., Berthoud, H., Booth, F. W., Cotman, C. W., Edgerton, V. R., Fleshner, M. R., Gandevia, S. C., Gomez‐Pinilla, F., Greenwood, B. N., Hillman, C. H., et al. (2006) · Obesity · doi:10.1038/oby.2006.46 · Cited by 958
Metadata
- Authors
- INGRAM, D. K.
- Venue
- Medicine & Science in Sports & Exercise
- Published
- 2000-09
- Volume
- 32
- Issue
- 9
- Pages
- 1623-1629
- ISSN
- 0195-9131 (ISSN-L)
- OpenAlex
- W2010204683
- Cited by
- 256
- References
- 0
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- closed
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- INGRAM, D. K. (2000). Age-related decline in physical activity: generalization to nonhumans. Medicine & Science in Sports & Exercise. https://doi.org/10.1097/00005768-200009000-00016
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
