The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
The Long-Term Mortality and Morbidity of Behçet Syndrome: A 2-Decade Outcome Survey of 387 Patients Followed at a Dedicated Center
Abstract
We surveyed the 20-year outcome of a cohort of patients with Behçet syndrome with emphasis on both mortality and morbidity. During 1999 and 2000, we collected outcome information on 387/428 (90.4%) of a cohort of patients (262 male, 125 female) who had registered in a dedicated outpatient clinic between July 1977 and December 1983. In 245/345 (71.0%) patients, outcome information was based on a formal hospital reevaluation, and in the remaining patients, on detailed telephone interviews. Forty-two patients (9.8%) (39 male, 3 female) had died, mainly due to major vessel disease and neurologic involvement. Mortality, as measured by standardized mortality ratios (SMR), was specifically increased among young males, among whom morbidity was also the highest. However, the SMR tended to decrease significantly with the passage of time. The same was also true for all mucocutaneous and articular manifestations. Both the onset of eye disease and its greatest damage were also usually within the first few years of disease onset. These suggest that the "disease burden" of Behçet syndrome is usually confined to the early years of its course, and in many patients the syndrome "burns out." However, central nervous system involvement and major vessel disease are exceptions. They can have their onset late (5-10 yr) during the disease course. As reflected in the mortality figures, the disease was less severe among the females for almost each disease manifestation. There were no female patients with arterial aneurysms. Severely impaired vision did not always mean an eventual loss of useful vision, and those patients with a late onset of eye disease had a better visual prognosis.
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Cites
Criteria for diagnosis of Behçet's disease
Weichsler, B., Davatchi, F., Lehner, T., O’Duffy, J. D., Rigby, A. S., & Gregory, J. K. (1990) · The Lancet · Cited by 3,082
The bimodal mortality pattern of systemic lupus erythematosus
Urowitz, M. B., Bookman, A. A. M., Koehler, B. E., Gordon, D. A., Smythe, H. A., & Ogryzlo, M. A. (1976) · The American Journal of Medicine · doi:10.1016/0002-9343(76)90431-9 · Cited by 1,000
Clinical patterns of neurological involvement in Behçet's disease: evaluation of 200 patients
Akman-Demir, G., Serdaroglu, P., & Tasçi, B. (1999) · Brain · doi:10.1093/brain/122.11.2171 · Cited by 793
A Controlled Trial of Azathioprine in Behçet's Syndrome
Yazici, H., Pazarli, H., Barnes, C. G., Tüzün, Y., Özyazgan, Y., Silman, A., Serdaroğlu, S., Oğuz, V., Yurdakul, S., Lovatt, G. E., et al. (1990) · New England Journal of Medicine · doi:10.1056/nejm199002013220501 · Cited by 647
Self-citationHamuryudan, V., Mat, C., Saip, S., Ozyazgan, Y., Siva, A., Yurdakul, S., Zwingenberger, K., & Yazici, H. (1998) · Annals of Internal Medicine · doi:10.7326/0003-4819-128-6-199803150-00004 · Cited by 456
Self-citationVascular involvement in Behçet’s disease
(2008) · Textbook of Peripheral Vascular Interventions · doi:10.3109/9781439801970-100 · Cited by 435
Yazici, H., Tüzün, Y., Pazarli, H., Yurdakul, S., Ozyazgan, Y., Ozdoğan, H., Serdaroğlu, S., Ersanli, M., Ulkü, B. Y., & Müftüoğlu, A. U. (1984) · Annals of the Rheumatic Diseases · doi:10.1136/ard.43.6.783 · Cited by 411
Self-citationA double-blind trial of colchicine in Beh�et's syndrome
Yurdakul, S., Mat, C., T�z�n, Y., �zyazgan, Y., Hamuryudan, V., Uysal, �., ?enocak, M., & Yazici, H. (2001) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200111)44:11<2686::aid-art448>3.0.co;2-h · Cited by 383
Self-citationAzathioprine in Behçet's syndrome. Effects on long‐term prognosis
Hamuryudan, V., Özyazgan, Y., Hizli, N., Mat, C., Yurdakul, S., Tüzün, Y., Şlenocak, M., & Yazici, H. (1997) · Arthritis & Rheumatism · doi:10.1002/art.1780400425 · Cited by 280
Self-citationBehçet's disease and the nervous system
Serdaroğlu, P. (1998) · Journal of Neurology · doi:10.1007/s004150050205 · Cited by 258
Cited by
EULAR recommendations for the management of Behçet disease
Hatemi, G., Silman, A., Bang, D., Bodaghi, B., Chamberlain, A. M., Gul, A., Houman, M. H., Kötter, I., Olivieri, I., Salvarani, C., et al. (2008) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2007.080432 · Cited by 718
Self-citationBehçet syndrome: a contemporary view
Yazici, H., Seyahi, E., Hatemi, G., & Yazici, Y. (2018) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2017.208 · Cited by 444
Self-citationBehçet's disease – a contemporary review
Mendes, D., Correia, M., Barbedo, M., Vaio, T., Mota, M., Gonçalves, O., & Valente, J. (2009) · Journal of Autoimmunity · doi:10.1016/j.jaut.2009.02.011 · Cited by 320
Gender differences in Behçet’s disease associated uveitis
Ucar-Comlekoglu, D., Fox, A., & Sen, H. N. (2014) · Journal of Ophthalmology · doi:10.1155/2014/820710 · Cited by 37
Metadata
- Authors
- Kural-Seyahi, E., Fresko, I., Seyahi, N., Ozyazgan, Y., Mat, C., Hamuryudan, V., Yurdakul, S., & Yazici, H.
- Venue
- Medicine
- Published
- 2003-01
- Volume
- 82
- Issue
- 1
- Pages
- 60-76
- ISSN
- 0025-7974 (ISSN-L)
- OpenAlex
- W2053503514
- Cited by
- 768
- References
- 13
- FWCI
- 16.76
- Type
- journal article
- Language
- en
- Open access
- closed
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