Cited by 106Endometriosis Research and TreatmentEctopic Pregnancy Diagnosis and ManagementGynecological conditions and treatments

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Endometriosis and Infertility: New Concepts

Ryan, Isabelle P., Taylor, Robert N.·1997·Obstetrical & Gynecological Survey

DOI 10.1097/00006254-199706000-00021

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Abstract

Endometriosis is a common gynecological disorder with varied symptomatology including chronic pelvic pain, dysmenorrhea, and infertility. The association of endometriosis and infertility has been recognized for years, although definite evidence of causality still eludes us. In this review, we will explore three general concepts that enhance our understanding of the cellular and molecular interactions contributing to the pathophysiology of this disorder and that have steered current research in endometriosis. First, we review evidence of a local peritoneal inflammatory process, supported by the findings of elevated cytokine and growth factor concentrations in peritoneal fluid of affected patients. Second, we propose a role for angiogenic factors in the establishment of ectopic implants. Third, we review evidence for biochemical differences of eutopic and ectopic endometrium in endometriosis patients, which may contribute to both the pathogenesis and sequelae of this important disorder. Through information derived from these research efforts, we hope to develop better therapeutic interventions as adjunctive or alternative therapies to our current medical and surgical armamentarium.

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Authors: Ryan, I. P., & Taylor, R. N.
Affiliations: University of California, San Francisco (US)
ORCID: Taylor, Robert N.
Venue: Obstetrical & Gynecological Survey
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1997-06
Volume: 52
Issue: 6
Pages: 365-371
ISSN: 0029-7828 (ISSN-L)
DOI: 10.1097/00006254-199706000-00021
OpenAlex: W2088871668
Cited by: 106
References: 52
Citations by year: 2026: 1 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 7 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 3 · 2014: 5 · 2013: 4 · 2012: 5
FWCI: 1.29
Type: journal article
Language: en
Open access: closed
Locations: Obstetrical & Gynecological Survey (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Health Sciences › Medicine › Obstetrics and Gynecology › Ectopic Pregnancy Diagnosis and Management
Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
Keywords: endometriosis, infertility, peritonitis, cytokines, growth factors, angiogenic factors, eutopic endometrium, endometriosis pathophysiology, chronic pelvic pain, dysmenorrhea
MeSH terms: Endometriosis, Female, Humans, Infertility, Female

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Endometriosis and Infertility: New Concepts

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