The DOI matches its Crossref record.
Invasive neonatal candidiasis: comparison of albicans and parapsilosis infection
Abstract
Severe infections caused by non-albicans Candida species are being increasingly reported among infants in neonatal intensive care units. To assess relative severity, mortality rates for C. albicans (CA) and C. parapsilosis (CP) infections in one neonatal intensive care unit from 1980 to 1990 were compared. Invasive candidiasis was defined as Candida recovery from a normally sterile body fluid or site with clinical signs of infection. Invasive candidiasis was diagnosed and systemic antifungal therapy initiated in 45 infants, 29 with CA and 16 with CP. No differences were found between CA and CP for birth weight, gestational age, age or weight at onset, presence of necrotizing enterocolitis, gastrointestinal or genitourinary anomalies, death (all causes), prior incidence or duration of antibiotics, parenteral nutrition, steroids or endotracheal intubation. Candida infection as the cause of death was more frequent with CA than CP (7 of 29 vs. 0 of 16; P = 0.034). Infants with CA were more likely to have antecedent thrush (P = 0.007) and perineal Candida dermatitis (P less than 0.02); those with CP were more likely to have vascular catheters at the time of positive culture (P less than 0.02). Though both pathogens occur in similar neonatal intensive care unit infants and can cause severe disease, CA appears more likely to result in death than CP.
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“However, neonates born prematurely or infants with low birth weight and prolonged rupture of cutaneous membranes, the cutaneous process may become invasive and produce acute disseminated candidiasis [165].”
From Guidelines for Treatment of Candidiasis (2004) · cites this paper as [165]
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Items 101–123 of 123
Estudio prospectivo de sepsis por Candida en el recién nacido
Caballero, S. J., Caballero, M. P. J., Gutiérrez, F., Zafra, M., Muñoz, M. D. H., Marcos, R. A., Cabañas, J. G., & Martínez, M. Z. (1998) · Anales de Pediatría · Cited by 2
Pammi, M., Asim, O., & Weisman, L. E. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006068 · Cited by 2
Pana, Z.-D., Ioannidou, M., & Roilides, E. (2011) · Current Fungal Infection Reports · doi:10.1007/s12281-011-0074-6 · Cited by 1
InvasiveCandidaInfections in Extremely Preterm Infants
Kim, C. S., & Lee, S. L. (2013) · Neonatal Medicine · doi:10.5385/nm.2013.20.3.369 · Cited by 1
Clinical Features and Outcomes of Renal Mycetoma Complicated byCandidaSepsis in Newborn Infants
Choi, B. G., Kim, C. S., & Lee, S. L. (2012) · Journal of the Korean Society of Neonatology · doi:10.5385/jksn.2012.19.4.237 · Cited by 1
Invasive fungal infections in children: advances and perspectives
Groll, A. H., Köhler, J. R., & Walsh, T. J. (2007) · Birkhäuser Basel eBooks · doi:10.1007/978-3-7643-8099-1_16 · Cited by 1
Neonatal Bacterial and Fungal Infections
Stronati, M., & Borghesi, A. (2016) · Springer eBooks · doi:10.1007/978-3-319-18159-2_254-1 · Cited by 1
Choobdar, F. A., Zarei, E., Navaeifar, M. R., Anari, A. M., & Aski, B. H. (2016) · Journal of Pediatrics Review · doi:10.17795/jpr-9286 · Cited by 1
Fungal infections in the neonatal intensive care unit
Hostetter, M. K. (2001) · Seminars in Pediatric Infectious Diseases · doi:10.1053/spid.2001.26637 · Cited by 1
Epidemiology of Candida Infections in the Intensive Care Unit
Hajjeh, R. A., & Lyon, G. M. (2002) · Perspectives on critical care infectious diseases · doi:10.1007/978-1-4615-0977-6_1 · Cited by 1
“Candidemia among neonates is predominantly caused by two species, C. albicansand C. parapsilosis.Duringthe 1970sandearly1980s, C. albicans was responsible for the majority ofcandidemia infections in NlCUpatients.However,inthelate1980sandearly1990s,theproportionof infections caused by C. parapsilosis gradually increase…”
BackgroundLevy, J. (1999) · Acta Clinica Belgica · doi:10.1080/17843286.1999.11754210
Rapid And Reliable Detection Of Fungemia By Polymerase Chain Reaction
Tirodker, U. H., Nataro, J. P., & Fairchild, K. D. (2004) · Springer eBooks · doi:10.1007/978-3-642-18480-2_19
Aspectos clínicos e terapêuticos da candidíase sistêmica em UTI neonatal: estudo de 60 casos
Pedroso, C. P. A. (2005) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.5.2005.tde-12042006-094635
Management of Candidiasis in Critically Ill Patients
Pai, M. P., Danziger, L. H., & Pendland, S. L. (2002) · Journal of Pharmacy Practice · doi:10.1106/umb5-3heg-23j1
“This disease can be lethal if left untreated, especially in at-risk neonates such as premature neonates, lowbirth-weight neonates, and infants with prolonged rupture of membranes.(39) The syndrome is usually manifested by widespread dermatitis, which is usually limited to the skin in healthy term neonates.”
BackgroundChoobdar, F. A., Zarei, E., Navaeifar, M. R., et al. (2016) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.5812/jpr.9286
“Renal involvement in neonatal candidemia varies from 5% to 33% (9-11).”
BackgroundYEAST AND FUNGAL INFECTIONS OF THE FETUS AND NEONATE
Demmler‐Harrison, G. J. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-4044-6.50081-9
(2006) · Springer eBooks · doi:10.1007/978-3-540-30096-0_8
Neonatal Bacterial and Fungal Infections
Stronati, M., & Borghesi, A. (2018) · Springer eBooks · doi:10.1007/978-3-319-29489-6_254
Fungal Infections in the Neonatal Intensive Care Unit
Hostetter, M. K. (2005) · Elsevier eBooks · doi:10.1016/b978-072169347-7.50043-3
The association between mycotic pneumonia and neonatal septicemia
Salman, S. K., Abdulateef, Y. M., & Al-Quhli, S. Q. T. (2024) · Journal of Biosafety and Biosecurity · doi:10.1016/j.jobb.2024.06.002
Dixit, A., Vashisht, R., Bhartiya, M., et al. (2025) · Medical Journal Armed Forces India · doi:10.1016/j.mjafi.2025.03.002
Metadata
- Authors
- FAIX, R. G.
- Affiliations
- Women's Hospital (US)
- Corresponding author
- FAIX, ROGER G.
- Venue
- The Pediatric Infectious Disease Journal
- Published
- 1992-02
- Volume
- 11
- Issue
- 2
- Pages
- 88-92
- ISSN
- 0891-3668 (ISSN-L)
- OpenAlex
- W2067549921
- Cited by
- 122
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2021: 1 · 2018: 1 · 2016: 5 · 2014: 2 · 2013: 8 · 2012: 4
- FWCI
- 2.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Pediatric Infectious Disease Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and Maternal Infections
- Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
- Keywords
- invasive candidiasis, neonatal candidiasis, Candida albicans, Candida parapsilosis, non-albicans Candida, mortality, antifungal therapy, vascular catheters, necrotizing enterocolitis, neonatal intensive care unit infants
- MeSH terms
- Candida, Candida albicans, Candidiasis, Female, Humans, Infant, Newborn, Intensive Care Units, Neonatal, Male
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