The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Childhood vaccinations and risk of asthma
Abstract
BACKGROUND: A few previous studies have suggested that childhood vaccines, particularly whole cell pertussis vaccine, may increase the risk of asthma. We evaluated the suggested association between childhood vaccinations and risk of asthma. METHODS: Cohort study involving 167,240 children who were enrolled in 4 large health maintenance organizations during 1991 to 1997, with follow-up from birth until at least 18 months to a maximum of 6 years of age. Vaccinations were ascertained through computerized immunization tracking systems, and onset of asthma was identified through computerized data on medical care encounters and medication dispensings. RESULTS: In the study 18,407 children (11.0%) developed asthma, with a median age at onset of 11 months. The relative risks (95% confidence intervals) of asthma were: 0.92 (0.83 to 1.02) for diphtheria, tetanus and whole cell pertussis vaccine; 1.09 (0.9 to 1.23) for oral polio vaccine; 0.97 (0.91 to 1.04) for measles, mumps and rubella (MMR) vaccine; 1.18 (1.02 to 1.36) for Haemophilus influenzae type b (Hib); and 1.20 (1.13 to 1.27) for hepatitis B vaccine. The Hib result was not consistent across health maintenance organizations. In a subanalysis restricted to children who had at least 2 medical care encounters during their first year, the relative risks decreased to 1.07 (0.71 to 1.60) for Hib and 1.09 (0.88 to 1.34) for hepatitis B vaccine. CONCLUSION: There is no association between diphtheria, tetanus and whole cell pertussis vaccine, oral polio vaccine or measles, mumps and rubella vaccine and the risk of asthma. The weak associations for Hib and hepatitis B vaccines seem to be at least partially accounted for by health care utilization or information bias.
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“Proportional hazard regression does not show a significant association between asthma and MMR vaccination (RR 0.97; 95% CI 0.91 to 1.04).”
From Vaccines for measles, mumps and rubella in children (2012) · cites this paper as DeStefano 2002
Citations
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Mast, E. E., Weinbaum, C. M., Fiore, A. E., Alter, M. J., Bell, B. P., Finelli, L., Rodewald, L. E., Douglas, J. M., Janssen, R. S., & Ward, J. W. (2006) · PubMed · Cited by 1,129
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Immunisation against infectious disease
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Metadata
- Authors
- DESTEFANO, F., GU, D., KRAMARZ, P., TRUMAN, B. I., IADEMARCO, M. F., MULLOOLY, J. P., JACKSON, L. A., DAVIS, R. L., BLACK, S. B., SHINEFIELD, H. R., MARCY, S. M., WARD, J. I., & CHEN, R. T.
- Affiliations
- Centers for Disease Control and Prevention (US)
- ORCID
- Venue
- The Pediatric Infectious Disease Journal
- Published
- 2002-06
- Volume
- 21
- Issue
- 6
- Pages
- 498-504
- ISSN
- 0891-3668 (ISSN-L)
- OpenAlex
- W2090329806
- Cited by
- 109
- References
- 40
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 5 · 2012: 2
- FWCI
- 6.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Pediatric Infectious Disease Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Social Sciences › Health › Vaccine Coverage and Hesitancy
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Keywords
- childhood immunization, asthma risk, whole-cell pertussis vaccine, DTP vaccine, oral polio vaccine, MMR vaccine, Haemophilus influenzae type b vaccine, hepatitis B vaccine, vaccine safety, health maintenance organizations
- MeSH terms
- Asthma, Child, Female, Humans, Infant, Infant, Newborn, Male, Poliovirus Vaccine, Oral, Risk Factors, Viral Vaccines, Cohort Studies, Diphtheria-Tetanus-Pertussis Vaccine, Incidence, Measles-Mumps-Rubella Vaccine
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