The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Delayed Effect of Denervation on Wound Contraction in Rat Skin
Abstract
Neuronal supply in soft tissues may be an important part of cutaneous wound healing. In order to observe the effect of denervation on wound contraction, rectangular full-thickness skin defects were created on the dorsum of two groups of Wistar rats. In the experimental group (n = 20), spinal nerves corresponding to the area of the open wound (T11 to L2) were isolated and divided bilaterally. In the control group (n = 20), the same pairs of spinal nerves were dissected but left intact. Limits of denervation were verified by the pinprick test. Wound healing, which is primarily in the form of wound contraction in this model, was evaluated by tracing wound margins onto millimetric paper weekly. Wound contraction was delayed significantly in the experimental group (p < 0.05) at all follow-up periods when compared with the controls. Loss of neuropeptide secretion from the nerve endings in denervated tissues may be responsible for the retarded wound contraction, since neuropeptides are thought to exert trophic effects on skin wound healing.
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In the citing paper
“It is well documented that sensory denervation impairs cutaneous wound healing through increased apoptosis and reduced proliferation50,51.”
From Neuropeptides Substance P and Calcitonin Gene Related Peptide Accelerate the Development and Fibrogenesis of Endometriosis (2019) · cites this paper as [51]
Citations
Cites
Calcitonin gene-related peptide in the nervous tissue
Ishida‐Yamamoto, A., & Tohyama, M. (1989) · Progress in Neurobiology · doi:10.1016/0301-0082(89)90006-3 · Cited by 161
Calcitonin gene-related peptide increases survival of a musculocutaneous critical flap in the rat
Kjartansson, J., & Dalsgaard, C. (1987) · European Journal of Pharmacology · doi:10.1016/0014-2999(87)90073-2 · Cited by 110
Kashihara, Y., Sakaguchi, M., & Kuno, M. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-11-03796.1989 · Cited by 86
A subcutaneous implant for wound healing studies in humans
Diegelmann, R. F., Lindblad, W. J., & Cohen, I. K. (1986) · Journal of Surgical Research · doi:10.1016/0022-4804(86)90156-3 · Cited by 73
Turnover of collagen in the adult rat after denervation
Klein, L., Dawson, M., & Heiple, K. G. (1977) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-197759080-00011 · Cited by 45
Hulsebosch, C. E., & Coggeshall, R. E. (1983) · Brain Research · doi:10.1016/0006-8993(83)90332-3 · Cited by 39
Denervation effects on newt limb regeneration: Collagen and collagenase
Mailman, M. L., & Dresden, M. H. (1979) · Developmental Biology · doi:10.1016/0012-1606(79)90082-4 · Cited by 18
Biochemical studies on pressure-sore healing in paraplegics
Kermani, S. R., Rehab, D., Siddiqui, M., et al. (1970) · Spinal Cord · doi:10.1038/sc.1970.6 · Cited by 12
Wound healing in the paraplegic patient.
Localio, S. A., Lowman, E. W., & Gibson, J. L. (1958) · PubMed · Cited by 10
Flagged first, then by citations
Research works printed but not linked: 4
- Basson, 1982, Surg Gynecol Obstet, 155, 9
- Muren, 1954, Acta Physiol Scand Suppl, 111, 148
- Sandberg, 1961, Acta Chir Scand, 121, 111
- Localio, 1958, Surgery, 44, 625
Cited by
Sorted by citations
Smith, P., & Liu, M. (2002) · Cell and Tissue Research · doi:10.1007/s00441-001-0477-8 · Cited by 102
Yan, D., Liu, X., & Guo, S.-W. (2019) · Scientific Reports · doi:10.1038/s41598-019-39170-w · Cited by 82
Sensory nerve-derived neuropeptides accelerate the development and fibrogenesis of endometriosis
Liu, X., Yan, D., & Guo, S.-W. (2019) · Human Reproduction · doi:10.1093/humrep/dey392 · Cited by 51
Fujiwara, T., Kubo, T., Kanazawa, S., Shingaki, K., Taniguchi, M., Matsuzaki, S., Gurtner, G. C., Tohyama, M., & Hosokawa, K. (2013) · Wound Repair and Regeneration · doi:10.1111/wrr.12059 · Cited by 31
Metadata
- Authors
- Engin, C., Demirkan, F., Ayhan, S., Atabay, K., & Baran, N. K.
- Affiliations
- Gazi University (TR)
- ORCID
- Ayhan, Sühan
- Venue
- Plastic and Reconstructive Surgery
- Published
- 1996-11
- Volume
- 98
- Issue
- 6
- Pages
- 1063-1067
- ISSN
- 0032-1052 (ISSN-L)
- OpenAlex
- W1971440149
- Cited by
- 59
- References
- 9
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 5 · 2023: 3 · 2022: 1 · 2021: 5 · 2020: 1 · 2019: 4 · 2018: 1 · 2016: 1 · 2015: 3 · 2013: 4 · 2012: 1
- FWCI
- 1.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Plastic & Reconstructive Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Planarian Biology and Electrostimulation
- Keywords
- denervation, wound contraction, skin wound healing, spinal nerve transection, neuropeptides, neuropeptide release, trophic effects, full-thickness skin defect, delayed wound healing
- MeSH terms
- Animals, Denervation, Skin, Wound Healing, Rats, Wistar, Rats
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