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Cited by 60Pancreatic and Hepatic Oncology ResearchPancreatitis Pathology and TreatmentGlobal Cancer Incidence and Screening

Do early symptoms of pancreatic cancer exist that can allow an earlier diagnosis?

Gullo, Lucio, Tomassetti, Paola, Migliori, Marina, Casadei, Riccardo, Marrano, Domenico·2001·Pancreas
DOI 10.1097/00006676-200103000-00017
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Abstract

Diagnosis of pancreatic cancer is made late, and prognosis remains extremely poor. This study was carried out to investigate whether symptoms exist before pain or jaundice that could suggest pancreatic cancer and favor earlier diagnosis. The study involved 305 patients with confirmed pancreatic cancer and 305 controls. All subjects were interviewed personally at least twice about their clinical history; pancreatic cancer patients were asked about any disturbances before abdominal pain or jaundice. Of the 305 pancreatic cancer patients, 151 (49.5%) had some prior disturbances, 108 (35.4%) 6 months or less before pain or jaundice and 43 (14.1%) more than 6 months before. Among the latter, 14 (4.6% of all patients) had had anorexia and/or early satiety and/or asthenia (7-20 months before pain or jaundice), 11 (3.6%) had disgust for coffee and/or smoking and/or wine (7-20 months before), 14 (4.6%) had diabetes (7-24 months before), and four (1.3%) had acute pancreatitis (8-26 months before). Among the controls, the only reports of these symptoms were two (0.7%) cases of asthenia (4 and 6 years earlier), 22 (7.2%) cases of diabetes (of which only two [0.7%] were diagnosed 7-24 months before the interview), and one (0.33%) case of acute pancreatitis (10 years earlier). Apart from acute pancreatitis, all the other differences between patients and controls were statistically significant. In approximately 15% of patients, disturbances existed more than 6 months before pain or jaundice, which, although not specific, could raise suspicion of the possibility of pancreatic cancer. These disturbances could represent the one current opportunity for an earlier diagnosis in a significant minority of pancreatic cancer patients.

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Crossref · 10.1097/00006676-200103000-00017

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Authors
Gullo, L., Tomassetti, P., Migliori, M., Casadei, R., & Marrano, D.
Affiliations
IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola (IT)
Corresponding author
Gullo, Lucio
ORCID
Casadei, Riccardo
Venue
Pancreas
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2001-03
Volume
22
Issue
2
Pages
210-213
ISSN
0885-3177 (ISSN-L)
DOI
10.1097/00006676-200103000-00017
OpenAlex
W1969522598
Cited by
60
References
9
Citations by year
2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2018: 4 · 2017: 4 · 2016: 2 · 2015: 1 · 2014: 4 · 2013: 3 · 2012: 4
FWCI
1.77
Type
journal article
Language
en
Open access
closed
Locations
  • Pancreas (publishedVersion)
  • PubMed (publishedVersion)
Funders
Vetenskapsrådet
Topics
  • Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
  • Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
  • Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
Keywords
pancreatic cancer, early symptoms, early diagnosis, anorexia, early satiety, asthenia, diabetes mellitus, acute pancreatitis
MeSH terms
Adult, Aged, Female, Humans, Male, Middle Aged, Pancreatic Neoplasms

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