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Hostility, Risk of Coronary Heart Disease, and Mortality
Abstract
Level of hostility (Ho) was assessed by a 50-item subscale of the Minnesota Multiphasic Personality Inventory at the initial examination of 1877 employed middle-aged men who were free of coronary heart disease (CHD). Ten-year incidence of major CHD events (myocardial infarction and CHD death) was lowest in the first quintile of the Ho scale's distribution, highest in the middle quintile, and intermediate in the other three quintiles. After adjustment for age, blood pressure, serum cholesterol level, cigarette smoking, and intake of ethanol, the relative odds of a major CHD event was 0.68 for men with Ho scores less than or equal to 10 points in comparison to men with higher scores. The Ho scale was positively associated with crude 20-year mortality from CHD, malignant neoplasms, and causes other than cardiovascular--renal diseases and malignant neoplasms. After adjustment for the risk factors listed above, the Ho scale had a statistically significant, positive, monotonic association with 20-year risk of death from all causes combined. A difference of 23 points on the Ho scale, i.e., the difference between the means of the first and the fifth quintiles, was associated with a 42% increase in the risk of death. These results support the previous findings of Williams et al. with respect to the Ho scale and coronary atherosclerosis, and also suggest that the Ho scale may be associated with factors having broad effects on survival.
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“for 10-year all-cause, CVD, and cancer mortality among midlife men [160]”
From Personality and Longevity: Knowns, Unknowns, and Implications for Public Health and Personalized Medicine (2011) · cites this paper as [160]
In the citing paper
“However, in the early 1980s investigators began to study hostility in particular [159, 160], concluding that it was the primary “toxic” component of the Type A personality [161, 162].”
From Personality and Longevity: Knowns, Unknowns, and Implications for Public Health and Personalized Medicine (2011) · cites this paper as [160]
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“There is a wealth of literature linking hostility with coronary heart disease (Barefoot et al., 1983; Hecker et al., 1988; Irvine et al., 1991; Matthews et al., 1977; Shekelle et al., 1983).”
BackgroundDecoding Hostility from Conversations Through Speech and Text Integration
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“The identification of individuals with high hostility holds significant implications in healthcare, notably in patient-provider interactions [2], [3], mental health assessments [4]– [6], and cardiovascular disease (CVD) risk [7]–[10].”
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Hermosilla, A., Pastor, M. T., Rufrancos, B. A., Cuéllar, M. L. G.-O., Nieto, M. O., & Martínez, A. P. (2025) · Clínica Contemporánea · doi:10.5093/cc2025a19 · Cited by 1
“Investigaciones longitudinales como la del Chicago Western Electric Study (Shekelle et al., 1983) han evidenciado que altos niveles de hostilidad predicen el desarrollo de enfermedad coronaria incluso 20 años después.”
Metadata
- Authors
- Shekelle, R. B., Gale, M., Ostfeld, A. M., & Paul, O.
- Affiliations
- Rush University Medical Center (US)
- Venue
- Psychosomatic Medicine
- Published
- 1983-05
- Volume
- 45
- Issue
- 2
- Pages
- 109-114
- ISSN
- 0033-3174 (ISSN-L)
- OpenAlex
- W2076459336
- Cited by
- 554
- References
- 0
- Citations by year
- 2025: 1 · 2024: 3 · 2019: 2 · 2018: 1 · 2017: 5 · 2016: 5 · 2015: 4 · 2014: 11 · 2013: 7 · 2012: 3
- FWCI
- 16.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychosomatic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- hostility, coronary artery disease, myocardial infarction, coronary heart disease mortality, MMPI, middle-aged men, personality traits, cardiovascular risk factors, all-cause mortality, cancer
- MeSH terms
- Adult, Alcohol Drinking, Chicago, Coronary Disease, Hostility, Humans, Male, Middle Aged, MMPI, Myocardial Infarction, Risk, Smoking
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