Norepinephrine alterations under stress conditions following the regular practice of meditation.
Abstract
The present study reexamined an investigation that found enhanced plasma norepinephrine (NE) levels during isometric handgrip after 30 days of meditation practice. Since hemodynamic activity did not show corresponding increases, it was suggested that meditation had down regulated the cardiovascular response to sympathetic stimulation. The present study assessed response to venipuncture as well as isometric stress. At posttest, meditators showed a trend towards higher plasma NE levels than controls during isometric handgrip. However, in contrast to previous speculation, this did not appear to represent cardiovascular down-regulation. At the same time, meditators produced the greater NE levels during venipuncture, accompanied by marginally lower heart rate. The results support the association between regular meditation and noradrenergic hyperactivation, but suggest the need for further investigation of underlying mechanisms.
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Increases in wake-related or sleep-inhibiting neurotransmitters such as norepinephrine, dopamine, and serotonin have been found in studies of non-Buddhist meditation, though the relationship between peripheral and brain levels is unclear.
“Increases in wake-related/sleep-inhibiting neurotransmitters, such as norepinephrine,16,26,47,112, 113 dopamine,114 and serotonin,77,115–118 have been found in studies of non-Buddhist forms of meditation, although the relationship between peripheral and brain levels is unclear.”
From Awakening is not a metaphor: the effects of Buddhist meditation practices on basic wakefulness (2014) · cites this paper as [113]
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Awakening is not a metaphor: the effects of Buddhist meditation practices on basic wakefulness
Britton, W. B., Lindahl, J. R., Cahn, B. R., Davis, J. H., & Goldman, R. E. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12279 · Cited by 134 · see citing works
- Authors
- Morrell, E. M., & Hollandsworth, J. G.
- Venue
- Psychosomatic Medicine
- Published
- 1986-03
- Volume
- 48
- Issue
- 3
- Pages
- 270-277
- ISSN
- 0033-3174 (ISSN-L)
- OpenAlex
- W2332562964
- Cited by
- 24
- References
- 0
- Citations by year
- 2022: 1 · 2013: 1
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychosomatic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG0029-09)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- meditation, norepinephrine, sympathetic nervous system, stress response, isometric handgrip, venipuncture, heart rate, cardiovascular response, hemodynamic response
- MeSH terms
- Adult, Arousal, Blood Pressure, Female, Heart Rate, Humans, Isometric Contraction, Male, Norepinephrine, Relaxation Therapy, Stress, Psychological
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