The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Sleep as a Mediator of the Stress-Immune Relationship
Abstract
OBJECTIVE: To evaluate the role of sleep in the relationship of intrusive thoughts/avoidance behaviors to natural killer cell (NKC) number and function. METHOD: Twenty-nine individuals seeking treatment for bereavement-related depression were studied in the sleep laboratory. Background and clinical variables, including the Impact of Event Scale (IES) and the Hamilton Rating Scale for Depression (HRSD), were administered during the week preceding a 3-night sleep study. Blood samples were collected upon awakening after the second or third night of sleep. RESULTS: Greater frequency of intrusive thoughts and avoidance behaviors was associated with more time spent awake during the first non-rapid eye movement period (NREM-1) and lower NKC number (p values < .01). Greater time spent awake during NREM-1 was associated with lower NKC numbers (p < .05). Regression analyses revealed that the significant relationship between symptoms of intrusion/avoidance and NKC number was no longer significant when time spent awake during NREM-1 was entered into the regression equation. Time spent awake during NREM-1 accounted for 12% of the variance in NKC number (p < .05), whereas intrusion/avoidance accounted for 7% of the variance in NKC number (NS). CONCLUSIONS: These results suggest that EEG-assessed sleep may be a significant correlate of the stress-immune relationship.
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“inflammatory markers (levels of IL-6, TNF, and CRP), lifestyle, and health status factors explained the association between higher mortality risk and self-reported short sleep duration”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [228]
In the citing paper
“the association with long sleep duration was predominantly explained by lifestyle and health status factors, but less so by inflammatory markers”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [228]
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Metadata
- Authors
- Hall, M., Baum, A., Buysse, D. J., Prigerson, H. G., Kupfer, D. J., & Reynolds, C. F.
- Affiliations
- University of Pittsburgh (US)
- ORCID
- Venue
- Psychosomatic Medicine
- Published
- 1998
- Volume
- 60
- Issue
- 1
- Pages
- 48-51
- ISSN
- 0033-3174 (ISSN-L)
- OpenAlex
- W2011727241
- Cited by
- 136
- References
- 21
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 6 · 2019: 4 · 2018: 3 · 2017: 5 · 2016: 2 · 2015: 4 · 2014: 6 · 2013: 7 · 2012: 3
- FWCI
- 3.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychosomatic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH-52247, P30MH052247, MH-37869, R01MH037869, MH30915)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- sleep, natural killer cells, intrusive thoughts, avoidance behavior, NREM sleep, sleep EEG, immune function, psychological stress
- MeSH terms
- Adult, Aged, Bereavement, Defense Mechanisms, Major Depressive Disorder, Double-Blind Method, Female, Humans, Killer Cells, Natural, Male, Middle Aged, Personality Inventory, Psychoneuroimmunology, Sleep Stages, Sleep, REM, Stress, Psychological, Polysomnography, Lymphocyte Count
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