The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Chronic Stress Modulates the Immune Response to a Pneumococcal Pneumonia Vaccine
Abstract
OBJECTIVE: Influenza and pneumonia account for significant morbidity and mortality, particularly in older individuals. Previous studies have shown that spousal caregivers of patients with dementia have poorer antibody and virus specific T cell responses to an influenza virus vaccine relative to noncaregiving control subjects. This study tested the hypothesis that stress can also significantly inhibit the IgG antibody response to a pneumococcal bacterial vaccine. METHOD: We measured antibody titers of current caregivers, former caregivers, and control subjects after vaccination with a pneumococcal bacterial vaccine. RESULTS: Caregivers showed deficits relative to controls and former caregivers in their antibody responses to vaccination. Although the groups did not differ before vaccination or in the rise in antibody 2 weeks or 1 month after vaccination, current caregivers had lower antibody titers 3 and 6 months after vaccination than either former caregivers or controls. CONCLUSIONS: These data, the first evidence that chronic stress can inhibit the stability of the IgG antibody response to a bacterial vaccine for pneumonia, provide additional evidence of health risks associated with dementia caregiving.
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In the citing paper
“A growing body of evidence has implicated caregiving as a risk factor for health.”
From Chronic stress and age-related increases in the proinflammatory cytokine IL-6. (2003) · cites this paper as [3]
In the citing paper
“they have poorer immune responses to influenza virus and pneumococcal pneumonia vaccines (2-4)”
From Chronic stress and age-related increases in the proinflammatory cytokine IL-6. (2003) · cites this paper as [3]
In the citing paper
“negative emotions contribute to greater risk for infection, prolonged infection, and delayed wound healing (1-5)”
From Chronic stress and age-related increases in the proinflammatory cytokine IL-6. (2003) · cites this paper as [3]
In the citing paper
“caregivers report more infectious illness episodes, and they have poorer immune responses to influenza virus and pneumococcal pneumonia vaccines than noncaregivers (1-4).”
From Chronic stress and age-related increases in the proinflammatory cytokine IL-6. (2003) · cites this paper as [3]
Citations
Cites
(1988) · Cited by 4,111
Caregiving as a Risk Factor for Mortality: The Caregiver Health Effects Study
Schulz, R., & Beach, S. R. (1999) · JAMA · doi:10.1001/jama.282.23.2215 · Cited by 3,340 · cited 2×
“These data provide additional evidence that caregiving increases the risk for morbidity and mortality among older adults (1) at least in part through maladaptive alterations in the immune response (15).”
BackgroundMeasuring the Functional Components of Social Support
Cohen, S., Mermelstein, R., Kamarck, T., & Hoberman, H. M. (1985) · Social Support: Theory, Research and Applications · doi:10.1007/978-94-009-5115-0_5 · Cited by 2,296 · cited 1×
“The summary score includes the four scales, with higher values indicating greater support (12).”
BackgroundFillenbaum, G. G., & Smyer, M. A. (1981) · Journal of Gerontology · doi:10.1093/geronj/36.4.428 · Cited by 1,127
Slowing of wound healing by psychological stress
Kiecolt-Glaser, J. K., Marucha, P. T., Mercado, A. M., Malarkey, W. B., & Glaser, R. (1995) · The Lancet · doi:10.1016/s0140-6736(95)92899-5 · Cited by 1,104
Self-citationChronic stress alters the immune response to influenza virus vaccine in older adults.
Kiecolt-Glaser, J. K., Glaser, R., Gravenstein, S., Malarkey, W. B., & Sheridan, J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.7.3043 · Cited by 789
Self-citationChronic stress in elderly carers of dementia patients and antibody response to influenza vaccination
Vedhara, K., Cox, N. K., Wilcock, G. K., Perks, P., Hunt, M., Anderson, S., Lightman, S. L., & Shanks, N. M. (1999) · The Lancet · doi:10.1016/s0140-6736(98)06098-x · Cited by 496
Irwin, M., Brown, M., Patterson, T., Hauger, R., Mascovich, A., & Grant, I. (1991) · The FASEB Journal · doi:10.1096/fasebj.5.15.1743441 · Cited by 219
Psychosocial Modulation of Cytokine-Induced Natural Killer Cell Activity in Older Adults
Esterling, B. A., Kiecolt‐Glaser, J. K., & Glaser, R. (1996) · Psychosomatic Medicine · doi:10.1097/00006842-199605000-00010 · Cited by 188
Self-citationThe Influence of Psychological Stress on the Immune Response to Vaccinesa
Glaser, R., Kiecolt‐Glaser, J. K., Malarkey, W. B., & Sheridan, J. F. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09603.x · Cited by 180
Self-citationMarital Stress: Immunologic, Neuroendocrine, and Autonomic Correlatesa
Kiecolt‐Glaser, J. K., Glaser, R., Cacioppo, J. T., & Malarkey, W. B. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09604.x · Cited by 156
Self-citationChronic stress alters the immune response to influenza virus vaccine in older adults
Kiecolt-Graser, J. (1996) · Medical Entomology and Zoology · Cited by 151
Chronic Stress and Mortality Among Older Adults
Kiecolt‐Glaser, J. K. (1999) · JAMA · doi:10.1001/jama.282.23.2259 · Cited by 90
Self-citationIrwin, M. R., Hauger, R. L., Patterson, T. L., Semple, S. J., Ziegler, M. G., & Grant, I. (1997) · Annals of Behavioral Medicine · doi:10.1007/bf02883324 · Cited by 88
Burns, E. A., & Goodwin, J. S. (1997) · Drugs & Aging · doi:10.2165/00002512-199711050-00005 · Cited by 80
Adrenocortical and Behavioral Predictors of Immune Responses to Starting School
Boyce, W. T., Adams, S. H., Tschann, J. M., Cohen, F., Wara, D. W., & Gunnar, M. R. (1995) · Pediatric Research · doi:10.1203/00006450-199512000-00030 · Cited by 70
Mills, P. J., Yu, H. H., Ziegler, M. G., Patterson, T. L., & Grant, I. (1999) · Psychosomatic Medicine · doi:10.1097/00006842-199903000-00008 · Cited by 51
Cited by
Sorted by citations
Psychological stress and the human immune system: a meta-analytic study of 30 Years of inquiry
Segerstrom, S. C., & Miller, G. E. (2004) · Psychological Bulletin · doi:10.1037/0033-2909.130.4.601 · Cited by 3,334
Pinquart, M., & Sörensen, S. (2003) · Psychology and Aging · doi:10.1037/0882-7974.18.2.250 · Cited by 2,857
Stress-induced immune dysfunction: implications for health
Glaser, R., & Kiecolt-Glaser, J. K. (2005) · Nature Reviews Immunology · doi:10.1038/nri1571 · Cited by 2,190
“Moreover, antibody responses to antibacterial vaccines are also influenced by stress: for example, following vaccination, antibody titres to a pneumococcal vaccine decreased during a 6-month period in the carers of spouses with dementia, whereas antibody titres were stable in non-carer”
Self-citationChronic stress and age-related increases in the proinflammatory cytokine IL-6.
Kiecolt-Glaser, J. K., Preacher, K. J., MacCallum, R. C., Atkinson, C., Malarkey, W. B., & Glaser, R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1531903100 · Cited by 1,267
Self-citationEmotions, morbidity, and mortality: new perspectives from psychoneuroimmunology.
Kiecolt-Glaser, J. K., McGuire, L., Robles, T. F., & Glaser, R. (2002) · Annual Review of Psychology · doi:10.1146/annurev.psych.53.100901.135217 · Cited by 1,176
“…of influenza virus infection, constitute the fourth leading cause of death among individuals who are 75 or older (Yoshikawa 1983); distressed older adults demonstrate poorer responses to both influenza and pneumococcal vaccines (Glaser et al. 2000, Kiecolt-Glaser et al. 1996a, Vedhara et al. 1999).”
BackgroundSelf-citation
Metadata
- Authors
- Glaser, R., Sheridan, J., Malarkey, W. B., MacCallum, R. C., & Kiecolt-Glaser, J. K.
- Affiliations
- The Ohio State University (US)
- Corresponding author
- Glaser, Ronald
- Venue
- Psychosomatic Medicine
- Published
- 2000-11
- Volume
- 62
- Issue
- 6
- Pages
- 804-807
- ISSN
- 0033-3174 (ISSN-L)
- OpenAlex
- W2109702099
- Cited by
- 295
- References
- 17
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 11 · 2023: 7 · 2022: 10 · 2021: 9 · 2020: 7 · 2019: 10 · 2018: 13 · 2017: 9 · 2016: 8 · 2015: 18 · 2014: 22 · 2013: 13 · 2012: 20
- FWCI
- 4.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychosomatic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01mh050538-05, 5k02mh001467-05, 5r37mh042096-15)
- National Institute of Mental Health (K02 MH01467, R37 MH42096, R01 MH50538)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
- Keywords
- chronic stress, pneumococcal vaccine, vaccine antibody response, IgG antibody titers, dementia caregivers, spousal caregiving, vaccine immunogenicity, pneumonia vaccination, older adults
- MeSH terms
- Alzheimer Disease, Antibodies, Bacterial, Female, Humans, Immune Tolerance, Male, Middle Aged, Streptococcus pneumoniae, Stress, Psychological, Caregivers, Pneumococcal Vaccines
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