The DOI matches its Crossref record.
The Effects of Frequent Nonoxynol-9 Use on the Vaginal and Cervical Mucosa
Abstract
The authors conducted a single-dose phase I local toxicity study of the effects of frequent insertion of nonoxynol-9 (N-9) on the lower genital tract to determine whether a phase II dose-ranging study is warranted. Fourteen women used 150 mg of N-9 cumulatively four times a day for 14 days. Epithelial disruption of the cervix and vagina, the main outcome of interest, occurred in 43% (95% CI, 18-71%) of women on this high-frequency use schedule. None of the women experienced symptoms that prompted them to discontinue the study. This preliminary study indicates that a phase II study to examine the local toxicity of different use schedules is needed to provide further safety information about the use of N-9.
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Cited by
Vulvovaginal candidiasis: Epidemiology, microbiology and risk factors
Gonçalves, B., Ferreira, C., Alves, C. T., Henriques, M., Azeredo, J., & Silva, S. (2016) · Critical Reviews in Microbiology · doi:10.3109/1040841x.2015.1091805 · Cited by 669
Roberts, J. N., Buck, C. B., Thompson, C. D., Kines, R., Bernardo, M., Choyke, P. L., Lowy, D. R., & Schiller, J. T. (2007) · Nature Medicine · doi:10.1038/nm1598 · Cited by 503
Risk Factors for Vulvovaginal Candidiasis: A Case- Control Study among University Students
Geiger, A. M., & Foxman, B. (1996) · Epidemiology · doi:10.1097/00001648-199603000-00013 · Cited by 154
Topical microbicides and HIV prevention in the female genital tract.
Cottrell, M. L., & Kashuba, A. D. M. (2014) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.292 · Cited by 22
Metadata
- Authors
- NIRUTHISARD, S., RODDY, R. E., & CHUTIVONGSE, S.
- Venue
- Sexually Transmitted Diseases
- Published
- 1991-07
- Volume
- 18
- Issue
- 3
- Pages
- 176-179
- ISSN
- 0148-5717 (ISSN-L)
- OpenAlex
- W1999530559
- Cited by
- 205
- References
- 0
- FWCI
- 12.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Effects of Frequent Nonoxynol-9 Use on the Vaginal and Cervical Mucosa. https://app.cochat.ai/papers/10.1097/00007435-199107000-00010
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- NIRUTHISARD, S., RODDY, R. E., & CHUTIVONGSE, S. (1991). The Effects of Frequent Nonoxynol-9 Use on the Vaginal and Cervical Mucosa. Sexually Transmitted Diseases. https://doi.org/10.1097/00007435-199107000-00010
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
