Topical microbicides and HIV prevention in the female genital tract.

Cottrell, Mackenzie L.; Kashuba, Angela D.M.

doi:10.1002/jcph.292

Cited by 22HIV/AIDS Research and InterventionsHIV/AIDS drug development and treatmentReproductive tract infections research

Topical microbicides and HIV prevention in the female genital tract.

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Cottrell, Mackenzie L., Kashuba, Angela D.M.·2014·The Journal of Clinical Pharmacology

DOI 10.1002/jcph.292PMC PMC4144014

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Abstract

Worldwide, HIV disproportionately affects women who are often unable to negotiate traditional HIV preventive strategies such as condoms. In the absence of an effective vaccine or cure, chemoprophylaxis may be a valuable self‐initiated alternative. Topical microbicides have been investigated as one such option. The first generation topical microbicides were non‐specific, broad‐spectrum antimicrobial agents, including surfactants, polyanions, and acid buffering gels, that generally exhibited contraceptive properties. After extensive clinical study, none prevented HIV infection, and their development was abandoned. Second generation topical microbicides include agents with selective mechanisms of antiviral activity. Most are currently being used for, or have previously been explored as, drugs for treatment of HIV. The most advanced of these is tenofovir 1% gel: the first topical agent shown to significantly reduce HIV infection by 39% compared to placebo. This review summarizes the evolution of topical microbicides for HIV chemoprophylaxis, highlights important concepts learned, and offers current and future considerations for this area of research.

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Nonspecific topical microbicides are ineffective for preventing HIV infection.
“Nonspecific topical microbicides are ineffective for preventing HIV infection (40–45).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [45]

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Preexposure chemoprophylaxis for HIV prevention in men who have sex with men.
Grant, R. M., Lama, J. R., Anderson, P. L., McMahan, V., Liu, A. Y., Vargas, L., Goicochea, P., Casapía, M., Guanira-Carranza, J. V., Ramirez-Cardich, M. E., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1011205 · Cited by 5,096 · see citing works
Antiretroviral prophylaxis for HIV prevention in heterosexual men and women.
Baeten, J. M., Donnell, D., Ndase, P., Mugo, N. R., Campbell, J. D., Wangisi, J., Tappero, J. W., Bukusi, E. A., Cohen, C. R., Katabira, E., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1108524 · Cited by 3,256 · see citing works
Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women.
Abdool Karim, Q., Abdool Karim, S. S., Frohlich, J. A., Grobler, A. C., Baxter, C., Mansoor, L. E., Kharsany, A. B. M., Sibeko, S., Mlisana, K. P., Omar, Z., et al. (2010) · Science · doi:10.1126/science.1193748 · Cited by 2,435 · see citing works
Antiretroviral preexposure prophylaxis for heterosexual HIV transmission in Botswana.
Thigpen, M. C., Kebaabetswe, P. M., Paxton, L. A., Smith, D. K., Rose, C. E., Segolodi, T. M., Henderson, F. L., Pathak, S. R., Soud, F. A., Chillag, K. L., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1110711 · Cited by 1,996 · see citing works
Preexposure Prophylaxis for HIV Infection among African Women
Damme, L. V., Corneli, A. L., Ahmed, K., Agot, K. E., Lombaard, J. J., Kapiga, S., Malahleha, M., Owino, F., Manongi, R. N., Onyango, J., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1202614 · Cited by 1,605 · see citing works
Self-citation
Antiretroviral prophylaxis for HIV infection in injecting drug users in Bangkok, Thailand (the Bangkok Tenofovir Study): a randomised, double-blind, placebo-controlled phase 3 trial.
Choopanya, K., Martin, M., Suntharasamai, P., Sangkum, U., Mock, P. A., Leethochawalit, M., Chiamwongpaet, S., Kitisin, P., Natrujirote, P., Kittimunkong, S., et al. (2013) · The Lancet · doi:10.1016/s0140-6736(13)61127-7 · Cited by 1,463 · see citing works
Effectiveness of COL-1492, a nonoxynol-9 vaginal gel, on HIV-1 transmission in female sex workers: a randomised controlled trial
Damme, L. V., Gita Ramjee, H., Alary, M., Vuylsteke, B., Chandeying, V., Rees, H., Sirivongrangson, P., Mukenge-Tshibaka, L., Ettiègne-Traoré, V., Uaheowitchai, C., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11079-8 · Cited by 796 · see citing works
Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: 18-month follow-up of the HIVNET 012 randomised trial
Jackson, J. B., Musoke, P., Fleming, T. R., Guay, L. A., Bagenda, D. S., Allen, M., Nakabiito, C., Sherman, J., Bakaki, P., Owor, M., et al. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14341-3 · Cited by 523 · see citing works
Efficacy of Carraguard for prevention of HIV infection in women in South Africa: a randomised, double-blind, placebo-controlled trial.
Skoler-Karpoff, S., Ramjee, G., Ahmed, K., Altini, L., Plagianos, M. G., Friedland, B., Govender, S., De Kock, A., Cassim, N., Palanee, T., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61842-5 · Cited by 502 · see citing works
Lack of effectiveness of cellulose sulfate gel for the prevention of vaginal HIV transmission.
Van Damme, L., Govinden, R., Mirembe, F. M., Guédou, F., Solomon, S., Becker, M. L., Pradeep, B. S., Krishnan, A. K., Alary, M., Pande, B., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0707957 · Cited by 438 · see citing works
Efficacy of Nonoxynol 9 Contraceptive Sponge Use in Preventing Heterosexual Acquisition of HIV in Nairobi Prostitutes
Kreiss, J. K. (1992) · JAMA · doi:10.1001/jama.1992.03490040053025 · Cited by 391 · see citing works
A Controlled Trial of Nonoxynol 9 Film to Reduce Male-to-Female Transmission of Sexually Transmitted Diseases
Roddy, R. E., Zekeng, L. A., Ryan, K. A., Tamoufé, U., Weir, S. S., & Wong, E. L. (1998) · New England Journal of Medicine · doi:10.1056/nejm199808203390803 · Cited by 366 · see citing works
PRO2000 vaginal gel for prevention of HIV-1 infection (Microbicides Development Programme 301): a phase 3, randomised, double-blind, parallel-group trial.
McCormack, S., Ramjee, G., Kamali, A., Rees, H., Crook, A. M., Gafos, M., Jentsch, U., Pool, R., Chisembele, M., Kapiga, S., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(10)61086-0 · Cited by 335 · see citing works
SAVVY vaginal gel (C31G) for prevention of HIV infection: a randomized controlled trial in Nigeria.
Feldblum, P. J., Adeiga, A., Bakare, R., Wevill, S., Lendvay, A., Obadaki, F., Olayemi, M. O., Wang, L., Nanda, K., & Rountree, W. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001474 · Cited by 280 · see citing works
Women’s Experiences with Oral and Vaginal Pre-Exposure Prophylaxis: The VOICE-C Qualitative Study in Johannesburg, South Africa
van der Straten, A., Stadler, J., Montgomery, E., Hartmann, M., Magazi, B., Mathebula, F., Schwartz, K. D., Laborde, N. D., & Soto-Torres, L. E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089118 · Cited by 254 · see citing works
Safety and effectiveness of BufferGel and 0.5% PRO2000 gel for the prevention of HIV infection in women
Karim, S. S. A., Richardson, B. A., Gita Ramjee, H., Hoffman, I., Chirenje, Z. M., Taha, T. E., Kapina, M., Maslankowski, L., Coletti, A., Profy, A. T., et al. (2011) · AIDS · doi:10.1097/qad.0b013e32834541d9 · Cited by 234 · see citing works
Drug concentrations after topical and oral antiretroviral pre-exposure prophylaxis: implications for HIV prevention in women
Karim, S. S. A., Kashuba, A. D. M., Werner, L., & Karim, Q. A. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60878-7 · Cited by 221 · see citing works
Self-citation
A Dosing Study of Nonoxynol-9 and Genital Irritation
Roddy, R. E., Cordero, M., Cordero, C., & Fortney, J. A. (1993) · International Journal of STD & AIDS · doi:10.1177/095646249300400308 · Cited by 219 · see citing works
The Effects of Frequent Nonoxynol-9 Use on the Vaginal and Cervical Mucosa
Niruthisard, S., Roddy, R. E., & Chutivongse, S. (1991) · Sexually Transmitted Diseases · doi:10.1097/00007435-199107000-00010 · Cited by 205 · see citing works
MTN-001: Randomized Pharmacokinetic Cross-Over Study Comparing Tenofovir Vaginal Gel and Oral Tablets in Vaginal Tissue and Other Compartments
Hendrix, C. W., Chen, B. A., Guddera, V., Hoesley, C. J., Justman, J. E., Nakabiito, C., Salata, R. A., Soto-Torres, L. E., Patterson, K., Minnis, A. M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055013 · Cited by 199 · see citing works
SAVVY® (C31G) Gel for Prevention of HIV infection in Women: A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial in Ghana
Peterson, L., Nanda, K., Opoku, B. K., Ampofo, W., Owusu-Amoako, M., Boakye, A., Rountree, W., Troxler, A., Dominik, R., Roddy, R. E., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001312 · Cited by 187 · see citing works
Acceptability of pre-exposure prophylaxis as an HIV prevention strategy: barriers and facilitators to pre-exposure prophylaxis uptake among at-risk Peruvian populations
Galea, J. T., Kinsler, J. J., Salazar, X., Lee, S.-J., Giron, M., Sayles, J. N., Cáceres, C., & Cunningham, W. E. (2011) · International Journal of STD & AIDS · doi:10.1258/ijsa.2009.009255 · Cited by 180 · see citing works
In Vitro and in Vivo Characterization of a Potential Universal Placebo Designed for Use in Vaginal Microbicide Clinical Trials
Tien, D., Schnaare, R. L., Kang, F., Cohl, G., McCormick, T. J., Moench, T. R., Doncel, G. F., Watson, K. M., Buckheit, R. W., Lewis, M. G., et al. (2005) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2005.21.845 · Cited by 178 · see citing works
Safety and tolerability of tenofovir vaginal gel in abstinent and sexually active HIV-infected and uninfected women
Mayer, K. H., Maslankowski, L., Gai, F., El-Sadr, W. M., Justman, J. E., Kwiecien, A., Mâsse, B. R., Eshleman, S. H., Hendrix, C. W., Morrow, K. M., et al. (2006) · AIDS · doi:10.1097/01.aids.0000210608.70762.c3 · Cited by 173 · see citing works
Long-term, controlled release of the HIV microbicide TMC120 from silicone elastomer vaginal rings
Malcolm, K. R., Woolfson, A. D., Toner, C. F., Morrow, R. J., & McCullagh, S. D. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki326 · Cited by 166 · see citing works
Effectiveness of Cellulose Sulfate Vaginal Gel for the Prevention of HIV Infection: Results of a Phase III Trial in Nigeria
Halpern, V., Ogunsola, F. T., Obunge, O., Wang, C.-H., Onyejepu, N. N., Oduyebo, O. O., Taylor, D., McNeil, L., Mehta, N., Umo-Otong, J., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003784 · Cited by 155 · see citing works
Gender power imbalance on women's capacity to negotiate self-protection against HIV/AIDS in Botswana and South Africa.
Langen, T. T. (2005) · African Health Sciences · doi:10.5555/afhs.2005.5.3.188 · Cited by 152 · see citing works
Strong Relationship between Oral Dose and Tenofovir Hair Levels in a Randomized Trial: Hair as a Potential Adherence Measure for Pre-Exposure Prophylaxis (PrEP)
Liu, A., Yang, Q., Huang, Y., Bacchetti, P., Anderson, P. L., Jin, C., Goggin, K., Stojanovski, K., Grant, R. M., Buchbinder, S., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0083736 · Cited by 150 · see citing works
Safety and Pharmacokinetics of Dapivirine Delivery From Matrix and Reservoir Intravaginal Rings to HIV-Negative Women
Nel, A. M., Smythe, S. C., Young, K., Malcolm, K. R., McCoy, C. F., Rosenberg, Z., & Romano, J. (2009) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e3181acb536 · Cited by 148 · see citing works
RMP-02/MTN-006: A Phase 1 Rectal Safety, Acceptability, Pharmacokinetic, and Pharmacodynamic Study of Tenofovir 1% Gel Compared with Oral Tenofovir Disoproxil Fumarate
Anton, P. A., Cranston, R., Kashuba, A. D. M., Hendrix, C. W., Bumpus, N. N., Richardson‐Harman, N., Elliott, J. E., Janocko, L. E., Khanukhova, E., Dennis, R., et al. (2012) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2012.0262 · Cited by 133 · see citing works
Self-citation
Safety and Availability of Dapivirine (TMC120) Delivered from an Intravaginal Ring
Romano, J., Variano, B., COPLAN, P. M., Roey, J. V., Douville, K. L., Rosenberg, Z., Temmerman, M., Verstraelen, H., Bortel, L. M. V., Weyers, S., et al. (2009) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2008.0184 · Cited by 133 · see citing works
Whither or Wither Microbicides?
Grant, R. M., Hamer, D. H., Hope, T. J., Johnston, R., Lange, J. M. A., Lederman, M. M., Lieberman, J., Miller, C. J., Moore, J. P., Mosier, D. E., et al. (2008) · Science · doi:10.1126/science.1160355 · Cited by 131 · see citing works
The rise and fall of polyanionic inhibitors of the human immunodeficiency virus type 1
Pirrone, V., Wigdahl, B. L., & Krebs, F. C. (2011) · Antiviral Research · doi:10.1016/j.antiviral.2011.03.176 · Cited by 122 · see citing works
Microbicides: Topical Prevention against HIVPreprint
Shattock, R. J., & Rosenberg, Z. (2011) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a007385 · Cited by 116 · see citing works
Disruption of Tight Junctions by Cellulose Sulfate Facilitates HIV Infection: Model of Microbicide Safety
Mesquita, P. M. M., Cheshenko, N., Wilson, S. S., Mhatre, M., Guzman, E. M., Fakioglu, E., Keller, M. J., & Herold, B. C. (2009) · The Journal of Infectious Diseases · doi:10.1086/600867 · Cited by 114 · see citing works
A Phase 1 Randomized, Double Blind, Placebo Controlled Rectal Safety and Acceptability Study of Tenofovir 1% Gel (MTN-007)
McGowan, I., Hoesley, C. J., Cranston, R., Andrew, P., Janocko, L. E., Dai, J. Y., Carballo‐Diéguez, A., Ayudhya, R. P. K. N., Piper, J. M., Hladik, F., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060147 · Cited by 112 · see citing works
Development and characterization of a vaginal film containing dapivirine, a non-nucleoside reverse transcriptase inhibitor (NNRTI), for prevention of HIV-1 sexual transmission
Akil, A., Parniak, M. A., Dezzutti, C. S., Moncla, B. J., Cost, M. R., Li, M., & Rohan, L. C. (2011) · Drug Delivery and Translational Research · doi:10.1007/s13346-011-0022-6 · Cited by 108 · see citing works
Nonclinical Toxicology Studies with Zidovudine: Genetic Toxicity Tests and Carcinogenicity Bioassays in Mice and Rats
AYERS, K. M. (1996) · Fundamental and Applied Toxicology · doi:10.1006/faat.1996.0118 · Cited by 105 · see citing works
Durable Protection from Vaginal Simian-Human Immunodeficiency Virus Infection in Macaques by Tenofovir Gel and Its Relationship to Drug Levels in Tissue
Dobard, C., Sharma, S., Martin, A., Pau, C., Holder, A. N., Kuklenyik, Z., Lipscomb, J. T., Hanson, D. L., Smith, J. M., Novembre, F. J., et al. (2011) · Journal of Virology · doi:10.1128/jvi.05842-11 · Cited by 102 · see citing works
Safety of multiple daily applications of COL-1492, a nonoxynol-9 vaginal gel, among female sex workers
Damme, L. V., Chandeying, V., Gita Ramjee, H., Rees, H., Sirivongrangson, P., Laga, M., & Perriëns, J. (2000) · AIDS · doi:10.1097/00002030-200001070-00010 · Cited by 98 · see citing works
Barrier contraceptive use and HIV infection among high-risk women in Cameroon
Zekeng, L. A., Feldblum, P. J., Oliver, R. M., & Kaptué, L. (1993) · AIDS · doi:10.1097/00002030-199305000-00018 · Cited by 96 · see citing works
Single and multiple exposure tolerance study of cellulose sulfate gel: a Phase I safety and colposcopy study
Mauck, C. K., Weiner, D. H., Ballagh, S. A., Creinin, M. D., Archer, D. F., Schwartz, J. L., Pymar, H. C., Lai, J.-J., & Callahan, M. M. (2001) · Contraception · doi:10.1016/s0010-7824(01)00271-2 · Cited by 92 · see citing works
Simultaneous Delivery of Tenofovir and Acyclovir via an Intravaginal Ring
Moss, J. A., Malone, A. M. D., Smith, T. J., Kennedy, S., Kopin, E. G., Nguyen, C., Gilman, J., Butkyavichene, I., Vincent, K. L., Motamedi, M., et al. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.05662-11 · Cited by 89 · see citing works
High Acceptability of a Vaginal Ring Intended as a Microbicide Delivery Method for HIV Prevention in African Women
van der Straten, A., Montgomery, E., Cheng, H., Wegner, L., Masenga, G. G., von Mollendorf, C., Bekker, L., Ganesh, S. K., Young, K., Romano, J., et al. (2012) · AIDS and Behavior · doi:10.1007/s10461-012-0215-0 · Cited by 89 · see citing works
Acceptability in microbicide and PrEP trials
Mensch, B., van der Straten, A., & Katzen, L. L. (2012) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0b013e3283590632 · Cited by 84 · see citing works
Fourteen-day safety and acceptability study of 6% cellulose sulfate gel: a randomized double-blind Phase I safety study
Schwartz, J. L., Mauck, C. K., Lai, J.-J., Creinin, M. D., Brache, V., Ballagh, S. A., Weiner, D. H., Hillier, S. L., Fichorova, R. N., & Callahan, M. M. (2006) · Contraception · doi:10.1016/j.contraception.2006.02.008 · Cited by 83 · see citing works
Safety, Adherence and Acceptability of Intermittent Tenofovir/Emtricitabine as HIV Pre-Exposure Prophylaxis (PrEP) among HIV-Uninfected Ugandan Volunteers Living in HIV-Serodiscordant Relationships: A Randomized, Clinical Trial
Kibengo, F., Ruzagira, E., Katende, D., Naggirinya, A. B., Bahemuka, U. M., Haberer, J. E., Bangsberg, D. R., Barin, B., Rooney, J. F., Mark, D., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074314 · Cited by 80 · see citing works
Safety and acceptability of cellulose sulfate as a vaginal microbicide in HIV-infected women
El-Sadr, W. M., Mayer, K. H., Maslankowski, L., Hoesley, C. J., Justman, J. E., Gai, F., Mauck, C. K., Absalon, J., Morrow, K. M., Mâsse, B. R., et al. (2006) · AIDS · doi:10.1097/01.aids.0000226950.72223.5f · Cited by 77 · see citing works
Reformulated tenofovir gel for use as a dual compartment microbicide
Dezzutti, C. S., Rohan, L. C., Wang, L., Uranker, K., Shetler, C., Cost, M. R., Lynam, J. D., & Friend, D. R. (2012) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dks173 · Cited by 75 · see citing works
Adherence and Acceptability in MTN 001: A Randomized Cross-Over Trial of Daily Oral and Topical Tenofovir for HIV Prevention in Women
Minnis, A. M., Gandham, S., Richardson, B. A., Guddera, V., Chen, B. A., Salata, R. A., Nakabiito, C., Hoesley, C. J., Justman, J. E., Soto-Torres, L. E., et al. (2012) · AIDS and Behavior · doi:10.1007/s10461-012-0333-8 · Cited by 73 · see citing works
The effect of contraceptives containing nonoxynol-9 on the genital transmission of simian immunodeficiency virus in rhesus macaques
Miller, C. J., Alexander, N. J., Gettie, A., Hendrickx, A. G., & Marx, P. A. (1992) · Fertility and Sterility · doi:10.1016/s0015-0282(16)55038-9 · Cited by 68 · see citing works
Effect of Computer-Assisted Interviewing on Self-Reported Sexual Behavior Data in a Microbicide Clinical Trial
Gorbach, P. M., Mensch, B., Husnik, M. J., Coly, A., Mâsse, B. R., Makanani, B., Nkhoma, C., Chinula, L., Tembo, T., Mierzwa, S., et al. (2012) · AIDS and Behavior · doi:10.1007/s10461-012-0302-2 · Cited by 66 · see citing works
The Use of Nonhuman Primate Models of HIV Infection for the Evaluation of Antiviral Strategies
Rompay, K. K. A. V. (2011) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2011.0234 · Cited by 61 · see citing works
Mucosal HIV-1 transmission and prevention strategies in BLT humanized mice
Denton, P. W., & García, J. V. (2012) · Trends in Microbiology · doi:10.1016/j.tim.2012.03.007 · Cited by 60 · see citing works
Heterosexual Anal Intercourse: A Neglected Risk Factor for HIV ?
Baggaley, R. F., Dimitrov, D., Owen, B. N., Pickles, M., Butler, A. R., Mâsse, B. R., & Boily, M. (2012) · American Journal of Reproductive Immunology · doi:10.1111/aji.12064 · Cited by 60 · see citing works
Expanded Phase I safety and acceptability study of 6% cellulose sulfate vaginal gel
Malonza, I., Mirembe, F. M., Nakabiito, C., Odusoga, L. O., Osinupebi, O. A., Hazari, K. T., Chitlange, S., Ali, M. M., Callahan, M. M., & Damme, L. V. (2005) · AIDS · doi:10.1097/01.aids.0000194797.59046.8f · Cited by 56 · see citing works
Assessment of Self-Reported Sexual Behavior and Condom Use Among Female Sex Workers in India Using a Polling Box Approach: A Preliminary Report
Hanck, S., Blankenship, K. M., Irwin, K. S., West, B. S., & Kershaw, T. (2008) · Sexually Transmitted Diseases · doi:10.1097/olq.0b013e3181653433 · Cited by 56 · see citing works
Adherence challenges with drugs for pre-exposure prophylaxis to prevent HIV infection
Gengiah, T. N., Moosa, A., Naidoo, A., & Mansoor, L. E. (2013) · International Journal of Clinical Pharmacy · doi:10.1007/s11096-013-9861-1 · Cited by 55 · see citing works
Freeze-dried, mucoadhesive system for vaginal delivery of the HIV microbicide, dapivirine: Optimisation by an artificial neural network
Woolfson, A. D., Umrethia, M. L., Kett, V. L., & Malcolm, K. R. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.12.042 · Cited by 54 · see citing works
Safety evaluation of nonoxynol-9 gel in women at low risk of HIV infection
Damme, L. V., Niruthisard, S., Atisook, R., Boer, K., Dally, L., Laga, M., Lange, J. M. A., Karam, M., & Perriëns, J. H. (1998) · AIDS · doi:10.1097/00002030-199804000-00013 · Cited by 53 · see citing works
A randomized Phase I vaginal safety study of three concentrations of C31G vs. Extra Strength Gynol II
Mauck, C. K., Weiner, D. H., Creinin, M. D., Barnhart, K. T., Callahan, M. M., & Bax, R. P. (2004) · Contraception · doi:10.1016/j.contraception.2004.04.010 · Cited by 48 · see citing works
The development of rectal microbicides for HIV prevention
McGowan, I. (2013) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2013.860132 · Cited by 47 · see citing works
“Tell Juliana”: Acceptability of the Candidate Microbicide VivaGel® and Two Placebo Gels Among Ethnically Diverse, Sexually Active Young Women Participating in a Phase 1 Microbicide Study
Carballo‐Diéguez, A., Giguere, R., Dolezal, C. L., Chen, B. A., Kahn, J. A., Zimet, G. D., Mabragaña, M., Leu, C., & McGowan, I. (2011) · AIDS and Behavior · doi:10.1007/s10461-011-0028-6 · Cited by 47 · see citing works
Tenofovir Diphosphate and Emtricitabine Triphosphate Concentrations in Blood Cells Compared With Isolated Peripheral Blood Mononuclear Cells
Adams, J. L., Sykes, C., Menezes, P., Prince, H. M. A., Patterson, K. B., Fransen, K., Crucitti, T., Baetselier, I. D., Damme, L. V., & Kashuba, A. D. M. (2012) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e3182794723 · Cited by 46 · see citing works
Self-citation
In Vitro Resistance Profile of the Candidate HIV-1 Microbicide Drug Dapivirine
Schader, S. M., Oliveira, M., Ibanescu, R.-I., Moisi, D. D., Colby-Germinario, S. P., & Wainberg, M. A. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.05821-11 · Cited by 42 · see citing works
Safety of single daily use for one week of C31G HEC gel in women
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Flagged first, then by citations

Research works printed but not linked: 11

[7]Marrazzo J Ramjee G Nair G Pre-exposure prophylaxis for HIV in women: Daily oral tenofovir, oral tenofovir/emtricitabine or vaginal tenofovir gel in the VOICE study (MTN 003) 2013 20th Conference on Retroviruses and Opportunistic Infections Atlanta, GA March 3–6 Abstract 26LB.
[51]Wainberg M The prospect for RT inhibitors as topical microbicides Microbicides 2004 Conference 2004 London, England Abstract MMM-03.
[55]Nicol M Emerson C Nelson J Tenofovir diphosphate concentration-response relationship for HIV prevention in vaginal tissue 21st Conference on Retroviruses and Opportunistic Infections 2014 Boston, MA Abstract 512.
[69]Baeten JM Donnell D Ndase P Antiretroviral prophylaxis for HIV prevention in heterosexual men and women N Engl J Med 2012 367 5 399 410 22784037 PMC3770474
[70]Karim SS Karim QA Effectiveness and safety of vaginal microbicide 1% tenofovir gel for prevention of HIV infection in women XVIII International AIDS Conference 2010 Vienna, Austria Abstract TUSS0204 and oral presentation.
[80]Hillier S HIV prevention research: Progress and challenges 21st Conference on Retroviruses and Opportunistic Infections 2014 Boston, MA Oral presentation
[85]Smith J Rastogi R Teller R A tenofovir disoproxil fumarate intravaginal ring completely protects against repeated SHIV vaginal challenge in nonhuman primates 20th Conference on Retroviruses and Opportunistic Infections 2013 Atlanta, Georgia
[86]Smith J Rastogi R Teller R A novel intravaginal ring design releasing tenofovir delivers comparable tenofovir diphosphate levels in vaginal target cells in macaques to gel dosing 20th Conference on Retroviruses and Opportunistic Infections 2013 Atlanta, GA
[94]Nel A Kamupira M Woodsong C Safety, acceptability and pharmacokinetic assessment (adherence) of monthly dapivirine vaginal microbicide rings (ring-004) for HIV prevention 19th Conference on Retrovirus and Opportunistic Infections 2012 Seattle, WA
[100]van der Straten A Brown E Marrazzo J Divergent adherence estimates with pharmacokinetic and behavioral measures in VOICE (MTN003) 21st Conference on Retroviruses and Opportunistic Infections 2014 Boston, MA Oral presentation
[107]Hillier SL Safety and acceptability of coitally dependent use of 1% tenofovir over six months of use Microbicides 2008 Conference 2008 New Delhi, India Abstract No. 655.

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Authors: Cottrell, M. L., & Kashuba, A. D. M.
Affiliations: University of North Carolina at Chapel Hill (US)
Corresponding author: Cottrell, Mackenzie L.
ORCID: Cottrell, Mackenzie L.
Kashuba, Angela D.M.
Venue: The Journal of Clinical Pharmacology
Publisher: Wiley
Published: 2014-03-28
Volume: 54
Issue: 6
Pages: 603-615
ISSN: 0021-9754 (ISSN-L)
0091-2700
1552-4604
DOI: 10.1002/jcph.292
PMC: PMC4144014
OpenAlex: W1513227883
Cited by: 22
References: 80
Citations by year: 2025: 1 · 2022: 1 · 2021: 3 · 2018: 3 · 2017: 1 · 2016: 7 · 2015: 4 · 2014: 2
FWCI: 0.65
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The Journal of Clinical Pharmacology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
UNC Libraries
Funders: U.S. Public Health Service (U01 AU095031)
National Institute of General Medical Sciences (T32GM086330)
National Institute of Allergy and Infectious Diseases (U01AI095031, P30AI050410)
Topics: Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
Keywords: topical microbicides, HIV prevention, female reproductive tract, tenofovir gel, antiviral agents, women's HIV risk, surfactant gels
MeSH terms: Animals, Anti-Infective Agents, Local, Female, Genitalia, Female, Humans, HIV Infections, Anti-HIV Agents, Medication Adherence

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Topical microbicides and HIV prevention in the female genital tract.

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