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Cited by 56Herpesvirus Infections and TreatmentsGenital Health and DiseaseCytomegalovirus and herpesvirus research

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

Patients’ Preference of Valacyclovir Once-Daily Suppressive Therapy Versus Twice-Daily Episodic Therapy for Recurrent Genital Herpes: A Randomized Study

ROMANOWSKI, BARBARA, MARINA, RAYMOND B., ROBERTS, JEREMY N.·2003·Sexually Transmitted Diseases
DOI 10.1097/00007435-200303000-00010
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Abstract

BACKGROUND: Valacyclovir is effective for suppressive and episodic treatment of recurrent genital herpes. Few data on patients' treatment strategy preferences are available. GOAL: The goal was to assess patients' preference, satisfaction, and quality of life with suppressive versus episodic treatment of recurrent genital herpes. STUDY DESIGN: This was a multicenter, open-label, randomized, two-arm, crossover 48-week study involving 225 patients with genital herpes. RESULTS: Suppressive valacyclovir therapy was preferred to episodic valacyclovir treatment by 72% of patients (P < 0.001). Overall treatment satisfaction and quality of life were significantly greater during suppressive therapy (P < 0.001 and P = 0.002, respectively). The risk of recurrence during the first 24 weeks was reduced by 78% with suppressive therapy (P < 0.001). Significantly fewer patients experienced recurrences during suppressive treatment than with episodic treatment (P < 0.001). Valacyclovir was well tolerated. CONCLUSIONS: Suppressive valacyclovir was preferred to episodic therapy by most patients. Suppressive therapy was associated with increased treatment satisfaction, and decreased risk and lower frequency of recurrences.

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Crossref · 10.1097/00007435-200303000-00010

Cites

19 of 19 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 7

  1. Goldmeier, 1988, Genitourin Med, 64, 327
  2. Emmert, 2000, Am Fam Phys, 61, 1697
  3. Patel, 1997, Genitourin Med, 73, 105
  4. Bodsworth, 1997, Genitourin Med, 73, 110
  5. Kaplan, 1958, J Am Stat Assoc, 53, 457, 10.2307/2281868 · DOI · Paper page
  6. Cox, 1972, J R Stat Soc, 187
  7. Jeffries, 1994, Antiviral Chem Chemother, 5, 23

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Metadata

Authors
ROMANOWSKI, B., MARINA, R. B., & ROBERTS, J. N.
Affiliations
  • University of Alberta (CA)
  • GlaxoSmithKline (Canada) (CA)
Corresponding author
ROMANOWSKI, BARBARA
ORCID
ROMANOWSKI, BARBARA
Venue
Sexually Transmitted Diseases
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2003-03
Volume
30
Issue
3
Pages
226-231
ISSN
0148-5717 (ISSN-L)
DOI
10.1097/00007435-200303000-00010
OpenAlex
W2054592903
Cited by
56
References
19
Citations by year
2026: 1 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 2 · 2016: 2 · 2015: 1 · 2014: 3 · 2013: 1
FWCI
3.27
Type
journal article
Language
en
Open access
closed
Locations
  • Sexually Transmitted Diseases (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Herpesvirus Infections and Treatments
  • Health Sciences › Medicine › Surgery › Genital Health and Disease
  • Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
Keywords
recurrent genital herpes, valacyclovir, suppressive therapy, patient preferences, treatment satisfaction, quality of life, recurrent herpes, antiviral therapy
MeSH terms
Valacyclovir, Acyclovir, Administration, Oral, Adult, Aged, Aged, 80 and over, Antiviral Agents, Canada, Drug Administration Schedule, Female, Herpes Genitalis, Humans, Male, Middle Aged, Quality of Life, Recurrence, Valine, Treatment Outcome, Patient Satisfaction, Cross-Over Studies

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