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Interaction Between Rifampin and Levothyroxine
Abstract
Rifampin is a potent inducer of hepatic enzymes and is well documented to cause many clinically significant drug interactions. Studies in normal volunteers have shown its ability to decrease circulating levels of thyroid hormone, while having no effect on thyroid-stimulating hormone (TSH). Reports of rifampin's effects on patients on hormone replacement in the clinical setting are of interest since we believe only one such case has been described. We report the case of a man, stable on levothyroxine, who exhibited significantly elevated TSH levels during therapy with rifampin. Thyroid-stimulating hormone levels returned to baseline 9 days after discontinuance of rifampin.
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“Moreover, increased inactivation of LT4 via the monodeiodinase induced by mifepristone, rifampicin, and carbamazepine can reduce the T1/2 of LT4 (86–88).”
From Levothyroxine: conventional and novel drug delivery formulations. (2023) · cites this paper as [88]
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Factors Affecting Gastrointestinal Absorption of Levothyroxine: A Review
Skelin, M., Lucijanić, T., Amidžić Klarić, D., Rešić, A., Bakula, M., Liberati-Čizmek, A.-M., Gharib, H., & Rahelić, D. (2017) · Clinical Therapeutics · doi:10.1016/j.clinthera.2017.01.005 · Cited by 133
Levothyroxine: conventional and novel drug delivery formulations.
Liu, H., Li, W., Zhang, W., Sun, S., & Chen, C. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnac030 · Cited by 63
Medications and Food Interfering with the Bioavailability of Levothyroxine: A Systematic Review
Liu, H., Lu, M., Hu, J., Fu, G., Feng, Q., Sun, S., & Chen, C. (2023) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s414460 · Cited by 29
Effect of Rifampin on Thyroid Function Test in Patients on Levothyroxine Medication
Kim, H. I., Kim, T. H., Kim, H., Kim, Y. N., Jang, H. W., Chung, J. H., Moon, S. M., Jhun, B. W., Lee, H., Koh, W.-J., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0169775 · Cited by 16
Pseudomalabsorption de L-thyroxine: une forme de pathomimie
Molines, L., Fromont, I., Morlet-Barla, N., Nogueira, J.-P., Valéro, R., & Vialettes, B. (2007) · La Presse Médicale · doi:10.1016/j.lpm.2006.09.024 · Cited by 10
Metadata
- Authors
- NOLAN, S. R., SELF, T. H., & NORWOOD, J. M.
- Affiliations
- University of Tennessee Health Science Center (US)
- ORCID
- SELF, TIMOTHY H.
- Venue
- Southern Medical Journal
- Publisher
- Southern Medical Association
- Published
- 1999-05
- Volume
- 92
- Issue
- 5
- Pages
- 529-531
- ISSN
- 0038-4348 (ISSN-L)
- OpenAlex
- W1507088428
- Cited by
- 42
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 4 · 2017: 2 · 2015: 3 · 2013: 2 · 2012: 1
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Southern Medical Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Keywords
- rifampicin, levothyroxine, drug interactions, thyroid-stimulating hormone, thyroid hormones, enzyme induction, hormone replacement therapy
- MeSH terms
- Drug Interactions, Enzyme Induction, Humans, Hypothyroidism, Liver, Male, Middle Aged, Rifampin, Surgical Wound Infection, Thyrotropin, Thyroxine
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