The DOI matches its Crossref record.
Epidemiology, Demographics, and Pathophysiology of Acute Spinal Cord Injury
Abstract
Spinal cord injury occurs through various countries throughout the world with an annual incidence of 15 to 40 cases per million, with the causes of these injuries ranging from motor vehicle accidents and community violence to recreational activities and workplace-related injuries. Survival has improved along with a greater appreciation of patterns of presentation, survival, and complications. Despite much work having been done, the only treatment to date known to ameliorate neurologic dysfunction that occurs at or below the level of neurologic injury has been intravenous methylprednisolone therapy. Much research over the past 30 to 40 years has focused on elucidating the mechanisms of spinal cord injury, with the complex pathophysiologic processes slowly being unraveled. With a greater understanding of both primary and secondary mechanisms of injury, the roles of calcium, free radicals, sodium, excitatory amino acids, vascular mediators, and apoptosis have been elucidated. This review examines the epidemiology, demographics, and pathophysiology of acute spinal cord injury.
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Citations
Cited by
Ding, W., Hu, S., Wang, P., Kang, H., Peng, R., Dong, Y., & Li, F. (2022) · Spine · doi:10.1097/brs.0000000000004417 · Cited by 459
Skeletal muscle atrophy and increased intramuscular fat after incomplete spinal cord injury
Gorgey, A. S., & Dudley, G. A. (2007) · Spinal Cord · doi:10.1038/sj.sc.3101968 · Cited by 415
Airway management in adults after cervical spine trauma
Crosby, E. T., & Warltier, D. C. (2006) · Anesthesiology · doi:10.1097/00000542-200606000-00026 · Cited by 401
Grimmer, M., Riener, R., Walsh, C. J., & Seyfarth, A. (2019) · Journal of NeuroEngineering and Rehabilitation · doi:10.1186/s12984-018-0458-8 · Cited by 249
Biomarkers in Spinal Cord Injury: Prognostic Insights and Future Potentials
Albayar, A. A., Roche, A., Swiatkowski, P., Antar, S., Ouda, N., Emara, E., Smith, D. H., Ozturk, A. K., & Awad, B. I. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00027 · Cited by 108
Effect of sacral anterior root stimulator on bowel dysfunction in patients with spinal cord injury
Vallès, M., Rodríguez, A., Borau, A., & Mearin, F. (2009) · Diseases of the Colon & Rectum · doi:10.1007/dcr.0b013e31819ed459 · Cited by 56
Should suspected cervical spinal cord injuries be immobilised? A systematic review protocol
Oteir, A. O., Jennings, P. A., Smith, K., & Stoelwinder, J. (2014) · Injury Prevention · doi:10.1136/injuryprev-2013-041080 · Cited by 12
Muscles in Motion: Wearables for Sports and Fitness
Upadhyay, P., Mittal, V., & Dass, R. (2025) · Smart Textiles and Wearables for Health and Fitness · doi:10.1002/9781394302895.ch12 · Cited by 1
Metadata
- Authors
- Sekhon, L. H. S., & Fehlings, M. G.
- Venue
- Spine
- Published
- 2001-12
- Volume
- 26
- Issue
- Supplement
- Pages
- S2-S12
- ISSN
- 0362-2436 (ISSN-L)
- OpenAlex
- W2003687276
- Cited by
- 1,434
- References
- 0
- FWCI
- 11.84
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
