The DOI matches its Crossref record.
A slow acetylator genotype is a risk factor for sulphonamide-induced toxic epidermal necrolysis and Stevens-Johnson syndrome
Abstract
Wolkenstein, Pierre; Carrière, Véronique; Charue, Dominique; Bastuji-Garin, Sylvie; Revuz, Jean; Roujeau, Jean-Claude; Beaune, Philippe; Bagot, Martine Author Information
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NAT2 slow acetylator genotype is a risk factor for Stevens-Johnson syndrome and toxic epidermal necrolysis from sulphonamide drugs, but that work did not relate genotype to acetylator phenotype in patients.
“Other work has shown that NAT2 slow acetylator genotype is a risk factor for Stevens-Johnson syndrome and toxic epidermal necrolysis from sulphonamide drugs but did not relate genotype to acetylator phenotype in patients.53”
From N-Acetyltransferase (NAT) 1 and NAT2 Enzyme Activities Drive Interindividual Variability in Sulfamethoxazole N-Acetylation (2025) · cites this paper as [53]
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Cytochrome p450 1b1: A major p450 isoenzyme in human blood monocytes and macrophage subsets
Baron, J. M., Zwadlo-Klarwasser, G., Jugert, F., Hamann, W., Rübben, A., Mukhtar, H., & Merk, H. F. (1998) · Biochemical Pharmacology · doi:10.1016/s0006-2952(98)00105-1 · Cited by 139
Wang, D., Para, M. F., Koletar, S. L., & Sadee, W. (2011) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e3283498ee9 · Cited by 53
Lanphier, R. M., Latham, B. D., Gerringer, A. J., Interrante, T., Jones, C. D., De Buysscher, T., Fallon, J. K., & Jackson, K. D. (2025) · Drug Metabolism and Disposition · doi:10.1016/j.dmd.2025.100195 · Cited by 1
Metadata
- Authors
- Wolkenstein, P., Carri??re, V., Charue, D., Bastuji-Garin, S., Revuz, J., Roujeau, J.-C., Beaune, P., & Bagot, M.
- Affiliations
- Centre Hospitalier Universitaire Henri-Mondor (FR)
- Hôpital Necker-Enfants Malades (FR)
- Venue
- Pharmacogenetics
- Published
- 1995-08
- Volume
- 5
- Issue
- 4
- Pages
- 255-258
- ISSN
- 0960-314X (ISSN-L)
- OpenAlex
- W2063069081
- Cited by
- 143
- References
- 0
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 5 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 4 · 2015: 1 · 2014: 1 · 2013: 5 · 2012: 11
- FWCI
- 3.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacogenetics (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Drug-Induced Adverse Reactions
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Keywords
- slow acetylation, sulfonamides, toxic epidermal necrolysis, Stevens-Johnson syndrome, drug-induced skin toxicity, risk factors
- MeSH terms
- Acetylation, Adolescent, Adult, Aged, Aged, 80 and over, Anticonvulsants, Arylamine N-Acetyltransferase, Female, Genotype, Humans, Male, Middle Aged, Risk Factors, Stevens-Johnson Syndrome, Sulfonamides, Trimethoprim, Sulfamethoxazole Drug Combination, Genetic Predisposition to Disease
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