The Relationship Between Donepezil and Behavioral Disturbances in Patients With Alzheimer's Disease
Abstract
The authors tested the hypothesis that behavioral disturbances are reported at significantly lower rates by caregivers of Alzheimer's disease (AD) patients receiving the antidementia drug donepezil, compared with a group of patients receiving no antidementia drug treatment. Patients administered donepezilfor 6 months (n=84) were compared with patients not on donepezil (n=248). Patients taking donepezil had significantly lower levels of behavioral disturbances than patients not receiving this agent (P< or =0.011). Specifically, donepezil patients were described as significantly (P< or =0.05) less likely to be threatening, destroy property, and talk loudly. Also, significantly fewer patients receiving donepezil were treated with sedatives (P< or =0.005). These findings support the growing body of evidence that cholinesterase inhibitors have psychotropic properties and reduce behavioral disturbances in patients with AD.
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- Authors
- Cummings, J. L., Donohue, J. A., & Brooks, R. L.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Donohue, Jane A.
- ORCID
- Cummings, Jeffrey L.
- Venue
- The American Journal of Geriatric Psychiatry
- Publisher
- Elsevier BV
- Published
- 2000-03
- Volume
- 8
- Issue
- 2
- Pages
- 134-140
- ISSN
- 1064-7481 (ISSN-L)
- OpenAlex
- W2053254879
- Cited by
- 71
- References
- 31
- Citations by year
- 2021: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2016: 1 · 2015: 1 · 2013: 1 · 2012: 2
- FWCI
- 6.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Geriatric Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (P50AG016570, AG 16570)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- donepezil, Alzheimer's disease, behavioral problems, cholinesterase inhibitors, psychotropic effects, sedative use, caregiver reports, dementia pharmacotherapy
- MeSH terms
- Donepezil, Aged, Aged, 80 and over, Alzheimer Disease, Mental Disorders, Humans, Indans, Neuropsychological Tests, Personality Assessment, Piperidines, Caregivers, Cost of Illness, Nootropic Agents
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