The DOI matches its Crossref record.
Postprandial hyperlipidemia and remnant lipoproteins.
Abstract
Improved methods for quantification of organ-specific contributions to postprandial hyperlipidemia indicate substantial increases in the concentration and altered properties of hepatogenous VLDL, in addition to accumulation of chylomicron remnants. Recent clinical studies support the hypothesis that small chylomicron remnants characterized by apolipoprotein (apo)B48 and VLDL remnants characterized by apolipoprotein B100 are atherogenic lipoproteins.
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“In contrast, there is no doubt that metabolic products of triglyceride-rich lipoproteins are atherogenic (140 -142).”
From Evaluation and Treatment of Hypertriglyceridemia: An Endocrine Society Clinical Practice Guideline (2012) · cites this paper as [142]
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Triglyceride Metabolism in the Liver
Alves‐Bezerra, M., & Cohen, D. E. (2017) · Comprehensive physiology · doi:10.1002/cphy.c170012 · Cited by 1,324
“Following emulsification, these lipid molecules are taken up by enterocytes and resynthesized into TG. TGs are packaged into chylomicrons, secreted into the lymphatic system and ultimately reach the plasma (112,122).”
Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis
Goldberg, I. J. (1996) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37569-6 · Cited by 1,029
Evaluation and Treatment of Hypertriglyceridemia: An Endocrine Society Clinical Practice Guideline
Berglund, L., Brunzell, J. D., Goldberg, A. C., Goldberg, I. J., Sacks, F., Murad, M. H., & Stalenhoef, A. F. H. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-3213 · Cited by 887
Non–High-Density Lipoprotein Cholesterol Level as a Predictor of Cardiovascular Disease Mortality
Cui, Y. A., Blumenthal, R. S., Flaws, J. A., Whiteman, M. K., LANGENBERG, P. W., Bachorik, P. S., & Bush, T. L. (2001) · Archives of Internal Medicine · doi:10.1001/archinte.161.11.1413 · Cited by 657
Monounsaturated Fatty Acids and Risk of Cardiovascular Disease
Kris‐Etherton, P. M. (1999) · Circulation · doi:10.1161/01.cir.100.11.1253 · Cited by 397
Metadata
- Authors
- Havel, R. J.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Havel, Richard J.
- Venue
- Current Opinion in Lipidology
- Published
- 1994-04
- Volume
- 5
- Issue
- 2
- Pages
- 102-109
- ISSN
- 0957-9672 (ISSN-L)
- OpenAlex
- W2046776466
- Cited by
- 209
- References
- 0
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 6 · 2022: 15 · 2021: 1 · 2020: 5 · 2019: 1 · 2018: 2 · 2017: 5 · 2016: 7 · 2015: 4 · 2014: 3 · 2013: 6 · 2012: 2
- FWCI
- 10.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Lipidology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Keywords
- postprandial lipemia, remnant lipoproteins, chylomicron remnants, VLDL remnants, apolipoprotein B-48, apolipoprotein B-100, atherogenic lipoproteins, hepatic VLDL secretion
- MeSH terms
- Apolipoproteins B, Chylomicrons, Coronary Disease, Food, Humans, Hyperlipidemias, Lipoproteins, Lipoproteins, VLDL, Triglycerides, Apolipoprotein B-48, Apolipoprotein B-100
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