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Cited by 288Lipid metabolism and disordersLipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

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Apolipoproteins C-I and C-III as important modulators of lipoprotein metabolism

Shachter, Neil S.·2001·Current Opinion in Lipidology
DOI 10.1097/00041433-200106000-00009
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Abstract

Apolipoprotein (apo)C-I and apoC-III are constituents of HDL and of triglyceride-rich lipoproteins that slow the clearance of triglyceride-rich lipoproteins by a variety of mechanisms. ApoC-I is an inhibitor of lipoprotein binding to the LDL receptor, LDL receptor-related protein, and VLDL receptor. It also is the major plasma inhibitor of cholesteryl ester transfer protein, and appears to interfere directly with fatty acid uptake. ApoC-III also interferes with lipoprotein particle clearance, but its principal role is as an inhibitor of lipolysis, both through the biochemical inhibition of lipoprotein lipase and by interfering with lipoprotein binding to the cell-surface glycosaminoglycan matrix where lipolytic enzymes and lipoprotein receptors reside. Variation in the expression of apoC-III has been credibly documented to have an important role in hypertriglyceridemia. Variation in the expression of apoC-I may also be important for hypertriglyceridemia under certain circumstances.

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Metadata

Authors
Shachter, N. S.
Affiliations
Columbia University (US)
Corresponding author
Shachter, Neil S.
Venue
Current Opinion in Lipidology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2001-06
Volume
12
Issue
3
Pages
297-304
ISSN
0957-9672 (ISSN-L)
DOI
10.1097/00041433-200106000-00009
OpenAlex
W2334791394
Cited by
288
References
5
Citations by year
2026: 3 · 2025: 1 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 6 · 2020: 6 · 2019: 5 · 2018: 2 · 2017: 3 · 2016: 7 · 2015: 15 · 2014: 11 · 2013: 15 · 2012: 15
FWCI
3.84
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Lipidology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Heart, Lung, and Blood Institute (P01HL057217, R01HL056232)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Keywords
apolipoprotein C-I, apolipoprotein C-III, lipoprotein metabolism, HDL cholesterol, triglyceride-rich lipoproteins, lipoprotein clearance, LDL receptor, LDL receptor-related protein, VLDL receptor, cholesteryl ester transfer protein, fatty acid uptake, lipoprotein lipase, lipolysis, hypertriglyceridemia
MeSH terms
Alleles, Animals, Apolipoproteins C, Gene Expression Regulation, Humans, Lipoproteins, Receptors, Immunologic, Receptors, LDL, Genetic Variation, Hypertriglyceridemia, Low Density Lipoprotein Receptor-Related Protein-1, Mice, Apolipoprotein C-I, Apolipoprotein C-III

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