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Cited by 103Lipid metabolism and disordersCholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Independent regulation of plasma apolipoprotein C–II and C–III concentrations in very low density and high density lipoproteins: implications for the regulation of the catabolism of these lipoproteins

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Le, N A, Gibson, J C, Ginsberg, H N·1988·Journal of Lipid Research
DOI 10.1016/s0022-2275(20)38512-6
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Abstract

Apolipoproteins C-II (apoC-II) and C-III (apoC-III) are distributed among all the major lipoprotein classes, particularly very low density (VLDL) and high density lipoproteins (HDL). We have determined concentrations of apoC-II and apoC-III in VLDL and HDL in subjects with a wide range of VLDL triglyceride and HDL cholesterol levels, and correlated these levels with fractional catabolic rates (FCR) of VLDL triglyceride and HDL apolipoprotein A-I (apoA-I). Both apoC-II and apoC-III levels increased in VLDL as VLDL apolipoprotein B (apoB) and triglyceride levels rose. The rate of rise of VLDL apoC-III, however, was approximately 3 times greater than that of apoC-II, and positive correlations were present between the ratio of VLDL apoC-III/apoC-II and both VLDL apoB (r = 0.59; P less than 0.01) and VLDL triglyceride (r = 0.70; P less than 0.005) levels. Univariate analysis demonstrated that the FCR for VLDL triglyceride was inversely related to the ratio of apoC-III/apoC-II in VLDL (r = -0.58; P less than 0.05), although this relationship was not significant in a multivariate analysis. In HDL, concentrations of apoC-III and apoA-I were correlated (r = 0.73; P less than 0.005) while no correlation was observed between apoC-II and apoA-I levels. Univariate analyses of HDL variables revealed inverse correlations between the concentration of apoC-III and the FCR for apoA-I (r = -0.67; P less than 0.005) and between the ratio of apoC-III/apoA-I and the FCR for apoA-I (r = -0.66; P le…

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  • In a group of 19 subjects, concentrations of apoC-III and apoA-I in HDL were significantly correlated (r = 0.73, P < 0.005).

    “Finally, Le, Gibson, and Ginsberg (49) demonstrated in a group of 19 subjects that concentrations of apoC-III and apoA-I in HDL were significantly correlated (r ϭ 0.73, P Ͻ 0.005) and that there was an inverse relationship between HDL apoC-III concentration and the FCR for apoA-I (r ϭ Ϫ0.67, P Ͻ 0.005).”

    From Plasma turnover of HDL apoC-I, apoC-III, and apoE in humans (2003) · cites this paper as [49]

  • In a group of 19 subjects, there was an inverse relationship between HDL apoC-III concentration and the FCR for apoA-I (r = -0.67, P < 0.005).

    “Finally, Le, Gibson, and Ginsberg (49) demonstrated in a group of 19 subjects that concentrations of apoC-III and apoA-I in HDL were significantly correlated (r ϭ 0.73, P Ͻ 0.005) and that there was an inverse relationship between HDL apoC-III concentration and the FCR for apoA-I (r ϭ Ϫ0.67, P Ͻ 0.005).”

    From Plasma turnover of HDL apoC-I, apoC-III, and apoE in humans (2003) · cites this paper as [49]

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Authors
Le, N. A., Gibson, J. C., & Ginsberg, H. N.
Affiliations
Icahn School of Medicine at Mount Sinai (US)
ORCID
Le, N A
Venue
Journal of Lipid Research
Publisher
Elsevier BV
Published
1988-05
Volume
29
Issue
5
Pages
669-677
ISSN
0022-2275 (ISSN-L)
DOI
10.1016/s0022-2275(20)38512-6
OpenAlex
W2337035603
Cited by
103
References
1
Citations by year
2020: 2 · 2019: 2 · 2018: 1 · 2017: 1 · 2015: 2 · 2013: 1 · 2012: 2
FWCI
3.21
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Lipid Research (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
National Heart, Lung, and Blood Institute (HL-36000, HL-23077, HL 21006)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Keywords
apolipoprotein C-II, apolipoprotein C-III, VLDL, high-density lipoprotein, lipoprotein catabolism, fractional catabolic rate, apolipoprotein A-I, apolipoprotein B, triglyceride-rich lipoproteins
MeSH terms
Adult, Apolipoproteins C, Female, Humans, Lipoproteins, HDL, Lipoproteins, VLDL, Male, Middle Aged, Triglycerides, Apolipoprotein C-II, Apolipoprotein C-III

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