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Cited by 40Sarcoma Diagnosis and TreatmentBone Tumor Diagnosis and TreatmentsAcute Lymphoblastic Leukemia research

The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.

Treatment of Refractory Osteosarcoma With Fractionated Cyclophosphamide and Etoposide

Rodríguez-Galindo, Carlos, Daw, Najat C., Kaste, Sue C., Meyer, William H., Dome, Jeffrey S., Pappo, Alberto S., Rao, Bhaskar N., Pratt, Charles B.·2002·Journal of Pediatric Hematology/Oncology
DOI 10.1097/00043426-200205000-00006
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Abstract

PURPOSE: Standard multiagent chemotherapy for osteosarcoma may include platinum compounds, doxorubicin, and high-dose methotrexate. By identifying new chemotherapeutic strategies, the outcome of these patients can be improved and the toxicity of treatment regimens decreased. PATIENTS AND METHODS: The authors evaluated the activity of the combination of cyclophosphamide (500 mg/m2 per day for 5 days) and etoposide (100 mg/m2 per day for 5 days) given with granulocyte colony-stimulating factor (G-CSF) to children with osteosarcoma unresponsive to conventional treatment. RESULTS: Fourteen patients with refractory osteosarcoma were treated with this combination. Twelve patients had been previously treated with a multiagent regimen that included carboplatin, ifosfamide, methotrexate, and doxorubicin. Seven of 11 evaluable patients had a poor histologic response in their primary tumor at the time of definitive surgery (Huvos grade 1 or 2). Sites of relapse included lung, bone, and brain. A total of 47 courses were given. An overall response rate of 28.5% was achieved. A complete response was obtained in one patient (7.1%), a partial response was obtained in three patients (21.4%), and stable disease for 1 to 4 months was achieved in five patients (35.7%). Five patients (35.7%) had progressive disease. Grade 4 neutropenia was the primary form of toxicity observed; the median duration of absolute neurophil count less than 500/microL was 4 days. CONCLUSIONS: The combination of cyclophosphamide and etoposide resulted in a response rate of 28.5% in patients with refractory or relapsed osteosarcoma, and its incorporation into front-line therapies deserves further evaluation.

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Crossref · 10.1097/00043426-200205000-00006

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Citations

Cites

Show all 52 references

Research works printed but not linked: 11

  1. Lilley, 1990, Cancer Res, 50, 284
  2. Teicher, 1989, Cancer Res, 49, 5994
  3. Meyer, 1994, Proceedings of the Annual Meeting of the American Association for Cancer Research, 35, 241
  4. Marti, 1985, Cancer Treat Rep, 69, 115
  5. Pratt, 1987, Cancer Treat Rep, 71, 131
  6. Sladek, 1984, Cancer Treat Rep, 68, 1247
  7. Boddy, 1993, Cancer Res, 53, 3758
  8. Ren, 1997, Cancer Res, 57, 4229
  9. Dombernofski, 1973, Acta Pathol Microbiol Scand, 81, 715
  10. Chang, 1985, Cancer Res, 45, 2434
  11. Kung, 1985, Proceedings of the Annual Meeting of the American Society of Clinical Oncology, 4, 235

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Metadata

Authors
Rodríguez-Galindo, C., Daw, N. C., Kaste, S. C., Meyer, W. H., Dome, J. S., Pappo, A. S., Rao, B. N., & Pratt, C. B.
Affiliations
St. Jude Children's Research Hospital (US)
ORCID
Venue
Journal of Pediatric Hematology/Oncology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2002-05
Volume
24
Issue
4
Pages
250-255
ISSN
1077-4114 (ISSN-L)
DOI
10.1097/00043426-200205000-00006
OpenAlex
W2073867312
Cited by
40
References
52
Citations by year
2026: 2 · 2024: 2 · 2023: 1 · 2022: 3 · 2020: 2 · 2019: 2 · 2018: 2 · 2016: 1 · 2015: 2 · 2014: 4 · 2012: 3
FWCI
2.48
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Pediatric Hematology/Oncology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Cancer Institute (CA-23099, P01CA023099, P 30CA 21765, P30CA021765)
Topics
  • Health Sciences › Medicine › Oncology › Sarcoma Diagnosis and Treatment
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone Tumor Diagnosis and Treatments
  • Health Sciences › Medicine › Hematology › Acute Lymphoblastic Leukemia research
Keywords
relapsed osteosarcoma, cyclophosphamide, etoposide, fractionated chemotherapy, granulocyte colony-stimulating factor, pediatric osteosarcoma, neutropenia, treatment toxicity, combination chemotherapy
MeSH terms
Adolescent, Antineoplastic Combined Chemotherapy Protocols, Bone Neoplasms, Child, Cyclophosphamide, Dose-Response Relationship, Drug, Etoposide, Female, Humans, Male, Neoplasm Recurrence, Local, Retrospective Studies, Osteosarcoma, Survival Rate, Treatment Outcome

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