Intensification of preoperative chemotherapy for osteogenic sarcoma: results of the Memorial Sloan-Kettering (T12) protocol.
Abstract
PURPOSE: It has been observed previously in osteosarcoma (OS) that the degree of necrosis of the resected primary tumor following a period of preoperative chemotherapy is predictive of subsequent event-free survival (EFS). The aim of this study was to determine if more intensive preoperative chemotherapy would increase the proportion of patients with a good histologic response and improve EFS. PATIENTS AND METHODS: Seventy-three patients with OS were treated at Memorial-Sloan Kettering Cancer Center (MSKCC) on the T12 protocol between 1986 and 1993. Patients were randomized between therapy based on the T10 protocol and therapy with more intensive preoperative chemotherapy. The more intensive preoperative regimen consisted of two courses of cisplatin (CDDP) and doxorubicin (DOX) in addition to the usual preoperative regimen of high-dose methotrexate (HD MTX) and bleomycin, cyclophosphamide, and dactinomycin (BCD). RESULTS: The regimen with more intensive preoperative chemotherapy achieved a modest increase in the proportion of patients with a good histologic response (44% with a grade III or IV histologic response v 37% in the control arm, 33% with grade IV histologic response v 13% in the control arm). EFS continued to correlate with histologic response. The actuarial 5-year EFS in patients with localized disease was 78% for the regimen with more intensive preoperative chemotherapy and 73% for the control arm. CONCLUSION: Despite modest increases in the proportion of patients with good histologic response with intensified preoperative chemotherapy, no improvement in EFS was observed.
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The dosage of chemotherapy given before surgery shifts the degree of necrosis but does not change the prognostic value of necrosis grading or influence survival.
“The dosage of chemotherapy given before surgery shifts the degree of necrosis but it does not change the prognostic value of necrosis grading nor influence survival 119 .”
From Osteosarcoma (2022) · cites this paper as [119]
Cites
The Statistical Analysis of Failure Time Data.
Aitkin, M. A., Kalbfleisch, J. D., & Prentice, R. L. (1981) · Biometrics · doi:10.2307/2530581 · Cited by 9,875 · see citing works
Link, M. P., Goorin, A. M., Miser, A. W., Green, A. A., Pratt, C. B., Belasco, J. B., Pritchard, J., Malpas, J. S., Baker, A. R., Kirkpatrick, J. A., et al. (1986) · New England Journal of Medicine · doi:10.1056/nejm198606193142502 · Cited by 1,203 · see citing works
Rosen, G., Caparros, B., Huvos, A. G., Kosloff, C., Nirenberg, A., Cacavio, A., Marcove, R. C., Lane, J. M., Mehta, B. M., & Urban, C. (1982) · Cancer · doi:10.1002/1097-0142(19820315)49:6 · Cited by 1,088 · see citing works
Self-citationChemotherapy for nonmetastatic osteogenic sarcoma: the Memorial Sloan-Kettering experience.
Meyers, P. A., Heller, G., Healey, J. H., Huvos, A. G., Lane, J. M., Marcove, R. C., Applewhite, A., Vlamis, V., & Rosen, G. (1992) · Journal of Clinical Oncology · doi:10.1200/jco.1992.10.1.5 · Cited by 675 · see citing works
Self-citationPrimary osteogenic sarcoma. The rationale for preoperative chemotherapy and delayed surgery
Rosen, G., Marcove, R. C., Caparros, B., Nirenberg, A., Kosloff, C., & Huvos, A. G. (1979) · Cancer · doi:10.1002/1097-0142(197906)43:6 · Cited by 582 · see citing works
Self-citationAdjuvant chemotherapy for osteosarcoma: a randomized prospective trial.
Eilber, F. R., Giuliano, A. E., Eckardt, J. J., Patterson, K., Moseley, S. H., & Goodnight, J. E. (1987) · Journal of Clinical Oncology · doi:10.1200/jco.1987.5.1.21 · Cited by 524 · see citing works
Osteogenic sarcoma. A study of six hundred cases.
Dahlin, D. C., & Coventry, M. B. (1967) · PubMed · Cited by 475 · see citing works
Provisor, A. J., Ettinger, L. J., Nachman, J. B., Krailo, M., Makley, J. T., Yunis, E. J., Huvos, A. G., Betcher, D. L., Baum, E. S., Kisker, C. T., et al. (1997) · Journal of Clinical Oncology · doi:10.1200/jco.1997.15.1.76 · Cited by 458 · see citing works
Self-citationWinkler, K., Beron, G., Delling, G., Heise, U., Kabisch, H., Purfürst, C., Berger, J., Ritter, J., Jürgens, H., & Gerein, V. (1988) · Journal of Clinical Oncology · doi:10.1200/jco.1988.6.2.329 · Cited by 457 · see citing works
Osteogenic sarcoma with clinically detectable metastasis at initial presentation.
Meyers, P. A., Heller, G., Healey, J. H., Huvos, A. G., Applewhite, A., Sun, M., & LaQuaglia, M. P. (1993) · Journal of Clinical Oncology · doi:10.1200/jco.1993.11.3.449 · Cited by 389 · see citing works
Self-citationOsteogenic Sarcoma under the Age of Twenty-one
Marcove, R. C., Miké, V., HAJEK, J. V., LEVIN, A. G., & Hutter, R. V. P. (1970) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-197052030-00001 · Cited by 365 · see citing works
Sæter, G., Alvegård, T. A., Elomaa, I., Stenwig, A. E., Holmström, T., & Solheim, Ø. P. (1991) · Journal of Clinical Oncology · doi:10.1200/jco.1991.9.10.1766 · Cited by 224 · see citing works
Killander, D., Dohlwitz, A., Engstedt, L., Franzén, S., Gahrton, G., GULLBRING, B., Holm, G., Holmgren, A., Höglund, S., KILLANDER, A., et al. (1976) · Cancer · doi:10.1002/1097-0142(197601)37:1 · Cited by 143 · see citing works
Self-citationBacci, G., Mercuri, M., Briccoli, A., Ferrari, S., Bertoni, F., Donati, D. M., Monti, C., Zanoni, A., Forni, C., & Manfrini, M. (1997) · PubMed · Cited by 109 · see citing works
Prognostic Variables in Osteosarcoma: A Multi-Institutional Study
Taylor, W. F., Ivins, J. C., Unni, K. K., Beabout, J. W., Golenzer, H. J., & Black, L. E. (1989) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/81.1.21 · Cited by 69 · see citing works
Central and peripheral myelinopathy associated with systemic neoplasia and chemotherapy
Mena, H., García, J. H., & Velandia, F. (1981) · Cancer · doi:10.1002/1097-0142(19811015)48:8 · Cited by 37 · see citing works
Current combined treatment of high-grade osteosarcomas.
Ta, D., & Dj, P. (1995) · PubMed · Cited by 12 · see citing works
Flagged first, then by citations
1 of the 18 references couldn’t be matched to a known paper.
Cited by
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Osteosarcoma: Current Treatment and a Collaborative Pathway to Success
Isakoff, M. S., Bielack, S., Meltzer, P. S., & Gorlick, R. G. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.59.4895 · Cited by 1,578 · see citing works
Self-citationOsteosarcoma treatment – Where do we stand? A state of the art review
Lütke, A., Meyers, P. A., Lewis, I. J., & Juergens, H. (2013) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2013.11.006 · Cited by 1,237 · see citing works
Self-citationBiology and Therapeutic Advances for Pediatric Osteosarcoma
Marina, N. M., Gebhardt, M. C., Teot, L. A., & Gorlick, R. G. (2004) · The Oncologist · doi:10.1634/theoncologist.9-4-422 · Cited by 663 · see citing works
Self-citationBeird, H. C., Bielack, S. S., Flanagan, A. M., Gill, J., Heymann, D., Janeway, K. A., Livingston, J. A., Roberts, R. D., Strauss, S. J., & Gorlick, R. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00409-y · Cited by 660 · see citing works
Self-citationChemotherapeutic adjuvant treatment for osteosarcoma: Where do we stand?
Anninga, J. K., Gelderblom, H., Fiocco, M., Kroep, J. R., Taminiau, A. H. M., Hogendoorn, P. C. W., & Egeler, R. M. (2011) · European Journal of Cancer · doi:10.1016/j.ejca.2011.05.030 · Cited by 456 · see citing works
Ferrari, S., Smeland, S., Mercuri, M., Bertoni, F., Longhi, A., Ruggieri, P., Alvegård, T. A., Picci, P., Capanna, R., Bernini, G., et al. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2004.00.5785 · Cited by 432 · see citing works
Postrelapse Survival in Osteosarcoma of the Extremities: Prognostic Factors for Long-Term Survival
Ferrari, S., Briccoli, A., Mercuri, M., Bertoni, F., Picci, P., Tienghi, A., Del Prever, A. B., Fagioli, F., Comandone, A., & Bacci, G. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.03.141 · Cited by 316 · see citing works
Expression of HER2/erbB-2 Correlates With Survival in Osteosarcoma
Gorlick, R. G., Huvos, A. G., Heller, G., Aledo, A., Beardsley, G. P., Healey, J. H., & Meyers, P. A. (1999) · Journal of Clinical Oncology · doi:10.1200/jco.1999.17.9.2781 · Cited by 301 · see citing works
Self-citationMetastatic osteosarcoma: a challenging multidisciplinary treatment
Meazza, C., & Scanagatta, P. (2016) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.2016.1168697 · Cited by 300 · see citing works
Current Treatment of Osteosarcoma
Ferguson, W. S., & Goorin, A. M. (2001) · Cancer Investigation · doi:10.1081/cnv-100102557 · Cited by 295 · see citing works
Skubitz, K. M., & D’Adamo, D. R. (2007) · Mayo Clinic Proceedings · doi:10.4065/82.11.1409 · Cited by 277 · see citing works
New targets and approaches in osteosarcoma
Gill, J. B., Ahluwalia, M., Geller, D., & Gorlick, R. G. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.09.003 · Cited by 274 · see citing works
Self-citationSandberg, A. A., & Bridge, J. A. (2003) · Cancer Genetics and Cytogenetics · doi:10.1016/s0165-4608(03)00105-5 · Cited by 260 · see citing works
Rozen, P., Lubin, F., Papo, N., Knaani, J., Farbstein, H., Farbstein, M., & Zajicek, G. (2001) · Cancer · doi:10.1002/1097-0142(20010215)91:4 · Cited by 27 · see citing works
Osteosarcoma: Review of the Past, Impact on the Future. The American Experience
Jaffe, N. (2009) · Cancer treatment and research · doi:10.1007/978-1-4419-0284-9_12 · Cited by 252 · see citing works
Chou, A. J., Kleinerman, E. S., Krailo, M. D., Chen, Z., Betcher, D. L., Healey, J. H., Conrad, E. U., Nieder, M. L., Weiner, M. A., Wells, R. J., et al. (2009) · Cancer · doi:10.1002/cncr.24566 · Cited by 245 · see citing works
Self-citationSurgical options for children with osteosarcoma
Grimer, R. J. (2005) · The Lancet Oncology · doi:10.1016/s1470-2045(05)01734-1 · Cited by 238 · see citing works
Monitoring therapeutic responses of primary bone tumors by diffusion-weighted image: initial results
Hayashida, Y., Yakushiji, T., Awai, K., Katahira, K., Nakayama, Y., Shimomura, O., Kitajima, M., Hirai, T., Yamashita, Y., & Mizuta, H. (2006) · European Radiology · doi:10.1007/s00330-006-0342-y · Cited by 209 · see citing works
Programmed Cell Death Ligand 1 Expression in Osteosarcoma
Shen, J. K., Cote, G. M., Choy, E., Yang, P., Harmon, D. C., Schwab, J. H., Nielsen, G. P., Chebib, I. A., Ferrone, S., Wang, X., et al. (2014) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-13-0224 · Cited by 195 · see citing works
Petrilli, A. S., de Camargo, B., Filho, V. O., Bruniera, P., Brunetto, A. L., Jesús-García, R., de Camargo, O. P., Pena, W., Baptista, P. P. R., Davi, A., et al. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2005.03.5352 · Cited by 188 · see citing works
Ulaner, G. A., Huang, H.-Y., Otero, J. E., Zhao, Z., Ben‐Porat, L., Satagopan, J. M., Gorlick, R. G., Meyers, P. A., Healey, J. H., Huvos, A. G., et al. (2003) · PubMed · Cited by 183 · see citing works
Self-citationImproved outcomes in patients with osteogenic sarcoma of the head and neck
Patel, S. G., Meyers, P. A., Huvos, A. G., Wolden, S. L., Singh, B., Shaha, A. R., Boyle, J. O., Pfister, D. G., Shah, J. P., & Kraus, D. H. (2002) · Cancer · doi:10.1002/cncr.10849 · Cited by 179 · see citing works
Self-citationChi, S. N., Gardner, S. L., Levy, A., Knopp, E. A., Miller, D. C., Wisoff, J. H., Weiner, H. L., & Finlay, J. L. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.12.126 · Cited by 176 · see citing works
Neoadjuvant chemotherapy for osteosarcoma of the extremity
Bacci, G., Briccoli, A., Ferrari, S., Longhi, A., Mercuri, M., Capanna, R., Donati, D. M., Lari, S., Forni, C., & PAOLIS, M. D. (2001) · European Journal of Cancer · doi:10.1016/s0959-8049(01)00229-5 · Cited by 173 · see citing works
Deley, M. L., Guinebretière, J. M., Gentet, J., Pacquement, H., Pichon, F., Marec‐Bérard, P., Entz‐Werlé, N., Schmitt, C., Brugières, L., Vanel, D., et al. (2007) · European Journal of Cancer · doi:10.1016/j.ejca.2006.10.023 · Cited by 160 · see citing works
Mechanisms of methotrexate resistance in osteosarcoma.
Guo, W., Healey, J. H., Meyers, P. A., Ladanyi, M., Huvos, A. G., Bertino, J. R., & Gorlick, R. G. (1999) · PubMed · Cited by 152 · see citing works
Self-citationNational Cancer Data Base report on osteosarcoma of the head and neck
Smith, R. B., Apostolakis, L. W., Karnell, L. H., Koch, B. B., Robinson, R. A., Zhen, W. K., Menck, H. R., & Hoffman, H. T. (2003) · Cancer · doi:10.1002/cncr.11716 · Cited by 151 · see citing works
Recurrent osteosarcoma with a single pulmonary metastasis: a multi-institutional review
Daw, N. C., Chou, A. J., Jaffe, N., Rao, B. N., Billups, C. A., Galindo, C. R., Meyers, P. A., & Huh, W. W. (2014) · British Journal of Cancer · doi:10.1038/bjc.2014.585 · Cited by 149 · see citing works
Self-citationNeoadjuvant Chemotherapy and Local Radiotherapy for High-Grade Osteosarcoma of the Extremities
Machak, G. N., Si, T., Solovyev, Y. N., Sinyukov, P. A., Ivanov, S. M., Кочергина, Н. В., Ryjkov, A. D., Тепляков, В. В., Bokhyan, B. Y., & Glebovskaya, V. V. (2003) · Mayo Clinic Proceedings · doi:10.4065/78.2.147 · Cited by 149 · see citing works
Arunachalam, H. B., Mishra, R., Daescu, O., Cederberg, K., Rakheja, D., Sengupta, A. L., Leonard, D., Hallac, R. R., & Leavey, P. J. (2019) · PLoS ONE · doi:10.1371/journal.pone.0210706 · Cited by 146 · see citing works
Suehara, Y., Alex, D., Bowman, A., Middha, S., Zehir, A., Chakravarty, D., Wang, L., Jour, G., Nafa, K., Hayashi, T., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-4032 · Cited by 135 · see citing works
Self-citationHigh-Dose Chemotherapy in the Treatment of Relapsed Osteosarcoma: An Italian Sarcoma Group Study
Fagioli, F., Aglietta, M., Tienghi, A., Ferrari, S., del Prever, A. B., Vassallo, E., Palmero, A., Biasin, E., Bacci, G., Picci, P., et al. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.08.081 · Cited by 133 · see citing works
Treatment of osteosarcoma at first recurrence after contemporary therapy
Chou, A. J., Merola, P. R., Wexler, L. H., Gorlick, R. G., Vyas, Y. M., Healey, J. H., LaQuaglia, M. P., Huvos, A. G., & Meyers, P. A. (2005) · Cancer · doi:10.1002/cncr.21417 · Cited by 132 · see citing works
Self-citationDyke, J. P., Panicek, D. M., Healey, J. H., Meyers, P. A., Huvos, A. G., Schwartz, L. H., Thaler, H. T., Tofts, P. S., Gorlick, R. G., Koutcher, J. A., et al. (2003) · Radiology · doi:10.1148/radiol.2281011651 · Cited by 125 · see citing works
Self-citationKobayashi, E., Masuda, M., Nakayama, R. T., Ichikawa, H., Satow, R., Shitashige, M., Honda, K., Yamaguchi, U., Shoji, A., Tochigi, N., et al. (2010) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-0774 · Cited by 120 · see citing works
Hawkins, D. S., Conrad, E. U., Butrynski, J. E., Schuetze, S. M., & Eary, J. F. (2009) · Cancer · doi:10.1002/cncr.24421 · Cited by 119 · see citing works
Guo, J., Reddick, W. E., Glass, J. O., Ji, Q., Billups, C. A., Wu, J., Hoffer, F. A., Kaste, S. C., Jenkins, J. J., Flores, X. C. O., et al. (2011) · Cancer · doi:10.1002/cncr.26701 · Cited by 113 · see citing works
Kubo, T., Piperdi, S., Rosenblum, J., Antonescu, C. R., Chen, W., Kim, H., Huvos, A. G., Sowers, R. S., Meyers, P. A., Healey, J. H., et al. (2008) · Cancer · doi:10.1002/cncr.23437 · Cited by 112 · see citing works
Self-citationLumbar Spine MRI for Low Back Pain: Indications and Yield
Roudsari, B. S., & Jarvik, J. G. (2010) · American Journal of Roentgenology · doi:10.2214/ajr.10.4367 · Cited by 112 · see citing works
Telomerase Expression Predicts Unfavorable Outcome in Osteosarcoma
Sanders, R. P., Drissi, R., Billups, C. A., Daw, N. C., Valentine, M. B., & Dome, J. S. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.03.043 · Cited by 108 · see citing works
Emerging roles for long noncoding RNAs in skeletal biology and disease
Huynh, N. P. T., Anderson, B. A., Guilak, F., & McAlinden, A. (2016) · Connective Tissue Research · doi:10.1080/03008207.2016.1194406 · Cited by 104 · see citing works
International Collaboration is Feasible in Trials for Rare Conditions: The EURAMOS Experience
Marina, N. M., Bielack, S., Whelan, J. S., Smeland, S., Krailo, M., Sydes, M. R., Butterfaß‐Bahloul, T., Calaminus, G., & Bernstein, M. L. (2009) · Cancer treatment and research · doi:10.1007/978-1-4419-0284-9_18 · Cited by 102 · see citing works
Peiffert, D., Giovannini, M. F., Ducreux, M. P., Michel, P., François, É., Lemanski, C., Mirabel, X., Cvitkovic, F., Luporsi, É., Conroy, T., et al. (2001) · Annals of Oncology · doi:10.1023/a:1011107105538 · Cited by 99 · see citing works
Zhu, S.-G., Kukreja, R. C., Das, A., Chen, Q., Lesnefsky, E. J., & Xi, L. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.01.024 · Cited by 96 · see citing works
Staging of Primary Malignancies of Bone
Heck, R. K., Peabody, T. D., & Simon, M. A. (2006) · CA A Cancer Journal for Clinicians · doi:10.3322/canjclin.56.6.366 · Cited by 96 · see citing works
Huang, C. C., Hsu, P. C., Hung, Y.-C., Liao, Y. F., Liu, C. C., Hour, C. T., Kao, M.-C., Tsay, G. J., Hung, H., & Liu, G. Y. (2005) · APOPTOSIS · doi:10.1007/s10495-005-2947-z · Cited by 88 · see citing works
Outcome after local recurrence of osteosarcoma
Galindo, C. R., Shah, N. N., McCarville, M. B., Billups, C. A., Neel, M. N., Rao, B. N., & Daw, N. C. (2004) · Cancer · doi:10.1002/cncr.20214 · Cited by 84 · see citing works
Whelan, J. S., Seddon, B. M., & Perisoglou, M. (2006) · Current Treatment Options in Oncology · doi:10.1007/s11864-006-0020-y · Cited by 84 · see citing works
Mason, G. E., Aung, L., Gall, S., Meyers, P. A., Butler, R., Krüg, S., Kim, M., Healey, J. H., & Gorlick, R. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00210 · Cited by 81 · see citing works
Self-citationEselgrim, M., Grunert, H., Kühne, T., Zoubek, A., Kevric, M., Buerger, H., Jürgens, H., Mayer‐Steinacker, R., Gosheger, G., & Bielack, S. (2005) · Pediatric Blood & Cancer · doi:10.1002/pbc.20608 · Cited by 80 · see citing works
Meyers, P. A., & Chou, A. J. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-04843-7_17 · Cited by 79 · see citing works
Self-citationFerrari, S., Mercuri, M., Picci, P., Bertoni, F., del Prever, A. B., Tienghi, A., Mancini, A. F., Longhi, A., Rimondini, S., Donati, D. M., et al. (1999) · Tumori Journal · doi:10.1177/030089169908500607 · Cited by 79 · see citing works
Magnetic resonance imaging of bone marrow in oncology, Part 2
Hwang, S., & Panicek, D. M. (2007) · Skeletal Radiology · doi:10.1007/s00256-007-0308-4 · Cited by 78 · see citing works
Early Equivalence of Uncemented Press-fit and Compress® Femoral Fixation
Farfalli, G. L., Boland, P. J., Morris, C. D., Athanasian, E. A., & Healey, J. H. (2009) · Clinical Orthopaedics and Related Research · doi:10.1007/s11999-009-0912-9 · Cited by 76 · see citing works
Self-citationIgarashi, K., Kawaguchi, K., Kiyuna, T., Miyake, K., Miyake, M., Li, S., Han, Q., Tan, Y., Zhao, M. D., Li, Y., et al. (2018) · Cell Cycle · doi:10.1080/15384101.2018.1431596 · Cited by 75 · see citing works
High-Dose Methotrexate in Osteosarcoma: Let the Questions Surcease—Time for Final Acceptance
Jaffe, N., & Gorlick, R. G. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.14.7793 · Cited by 74 · see citing works
Self-citationFerguson, W. S., Harris, M. B., Goorin, A. M., Gebhardt, M. C., Link, M. P., Shochat, S. J., Siegal, G. P., Devidas, M., & Grier, H. E. (2001) · The American journal of pediatric hematology/oncology · doi:10.1097/00043426-200108000-00004 · Cited by 72 · see citing works
Neoadjuvant Chemotherapy for Osteosarcoma of the Extremity
Bacci, G., Forni, C., Ferrari, S., Longhi, A., Bertoni, F., Mercuri, M., Donati, D. M., Capanna, R., Bernini, G., Briccoli, A., et al. (2003) · Journal of Pediatric Hematology/Oncology · doi:10.1097/00043426-200311000-00006 · Cited by 70 · see citing works
The role of FDG PET/CT in patients treated with neoadjuvant chemotherapy for localized bone sarcomas
Palmerini, E., Colangeli, M., Nanni, C., Fanti, S., Marchesi, E., Paioli, A., Picci, P., Cambioli, S., Donati, D. M., Cevolani, L., et al. (2016) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-016-3509-z · Cited by 69 · see citing works
The Current and Future Therapies for Human Osteosarcoma
Lamplot, J. D., Denduluri, S. K., Qin, J., Li, R., Liu, X., Zhang, H., Chen, X., Wang, N., Pratt, A., Shui, W., et al. (2013) · Current Cancer Therapy Reviews · doi:10.2174/1573394711309010006 · Cited by 67 · see citing works
Human osteosarcoma expresses specific ephrin profiles
Varelias, A., Koblar, S. A., Cowled, P. A., Carter, C. D., & Clayer, M. (2002) · Cancer · doi:10.1002/cncr.10749 · Cited by 67 · see citing works
Chou, A. J., Gupta, R., Bell, M. D., O’Day, K., Meyers, P. A., & Gorlick, R. G. (2012) · Pediatric Blood & Cancer · doi:10.1002/pbc.24438 · Cited by 66 · see citing works
Self-citationYang, R. R., Kolb, E. A., Qin, J., Chou, A. J., Sowers, R. S., Hoang, B. H., Healey, J. H., Huvos, A. G., Meyers, P. A., & Gorlick, R. G. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1343 · Cited by 64 · see citing works
Self-citationChemotherapy for Bone Sarcoma in Adults
Wagner, M. J., Livingston, J. A., PATEL, S. R., & Benjamin, R. S. (2016) · Journal of Oncology Practice · doi:10.1200/jop.2015.009944 · Cited by 62 · see citing works
Chemotherapy in head and neck osteosarcoma: Adjuvant chemotherapy improves overall survival
Chen, Y., Gokavarapu, S., Shen, Q., Liu, F., Cao, W., Ling, Y.-H., & Ji, T. (2017) · Oral Oncology · doi:10.1016/j.oraloncology.2017.08.017 · Cited by 62 · see citing works
The patterns of relapse in osteosarcoma: The memorial Sloan‐Kettering experience
Chi, S. N., Conklin, L. S., Qin, J., Meyers, P. A., Huvos, A. G., Healey, J. H., & Gorlick, R. G. (2003) · Pediatric Blood & Cancer · doi:10.1002/pbc.10420 · Cited by 63 · see citing works
Self-citationBley, T. A., Wieben, O. E., & Uhl, M. (2009) · Magnetic Resonance Imaging Clinics of North America · doi:10.1016/j.mric.2009.01.005 · Cited by 64 · see citing works
Results of Treatment for Metastatic Osteosarcoma With Neoadjuvant Chemotherapy and Surgery
Thompson, R. C., Cheng, E. Y., Clohisy, D. R., Perentesis, J. P., Manivel, C. J., & Le, C. T. (2002) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-200204000-00028 · Cited by 62 · see citing works
Historical Perspective on the Introduction and Use of Chemotherapy for the Treatment of Osteosarcoma
Jaffe, N. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-04843-7_1 · Cited by 61 · see citing works
Meyers, P. A. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-43032-0_11 · Cited by 61 · see citing works
Self-citationBerger, M., Grignani, G., Ferrari, S., Biasin, E., Adalberto, B. D. P., Sandra, A., Saglio, F., Aglietta, M., & Franca, F. (2009) · Cancer · doi:10.1002/cncr.24368 · Cited by 61 · see citing works
Duffaud, F., Digue, L., Mercier, C., Dalès, J.-P., Baciuchka-Palmaro, M., Volot, F. G., Thomas, P. A., & Favre, R. (2003) · European Journal of Cancer · doi:10.1016/s0959-8049(03)00435-0 · Cited by 58 · see citing works
Histologic Response of High-Grade Nonmetastatic Osteosarcoma of the Extremity to Chemotherapy
Bacci, G., Ferrari, S. M., Bertoni, F., Picci, P., Bacchini, P., Longhi, A., Donati, D. M., Forni, C., Campanacci, L., & Campanacci, M. (2001) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-200105000-00024 · Cited by 57 · see citing works
Sequence alterations in the reduced folate carrier are observed in osteosarcoma tumor samples.
Yang, R. R., Sowers, R. S., Mazza, B., Healey, J. H., Huvos, A. G., Grier, H. E., Bernstein, M. L., Beardsley, G. P., Krailo, M., Devidas, M., et al. (2003) · PubMed · Cited by 57 · see citing works
Self-citationSpraker‐Perlman, H. L., Barkauskas, D. A., Krailo, M., Meyers, P. A., Schwartz, C. L., Doski, J. J., Gorlick, R. G., Janeway, K. A., & Isakoff, M. S. (2018) · Pediatric Blood & Cancer · doi:10.1002/pbc.27444 · Cited by 56 · see citing works
Self-citationAdjuvant therapy of osteosarcoma—A Phase II trial
Zalupski, M. M., Rankin, C. J., Ryan, J. R., Lucas, D. R., Muler, J. H., Lanier, K. S., Budd, G. T., Biermann, J. S., Meyers, F. J., & Antman, K. H. (2004) · Cancer · doi:10.1002/cncr.20021 · Cited by 56 · see citing works
Yang, R., Hoang, B. H., Kubo, T., Kawano, H., Chou, A. J., Sowers, R. S., Huvos, A. G., Meyers, P. A., Healey, J. H., & Gorlick, R. G. (2007) · International Journal of Cancer · doi:10.1002/ijc.22749 · Cited by 55 · see citing works
Self-citationVásquez, L., Tarrillo, F., Oscanoa, M., Maza, I., Gerónimo, J., Paredes, G., Silva, J. M., & Sialer, L. (2016) · Frontiers in Oncology · doi:10.3389/fonc.2016.00022 · Cited by 55 · see citing works
Mansky, P. J., Liewehr, D. J., Steinberg, S. M., Chrousos, G. P., Avila, N. A., Long, L., Bernstein, D. B., Mackall, C. L., Hawkins, D. S., & Helman, L. J. (2002) · Journal of Pediatric Hematology/Oncology · doi:10.1097/00043426-200208000-00007 · Cited by 55 · see citing works
Haddox, C. L., Han, G., Anijar, L., Binitie, O. T., Letson, G. D., Bui, M. M., & Reed, D. R. (2014) · Sarcoma · doi:10.1155/2014/402509 · Cited by 53 · see citing works
Igarashi, K., Murakami, T., Kawaguchi, K., Kiyuna, T., Miyake, K., Zhang, Y., Nelson, S. D., Dry, S., Li, Y., Yanagawa, J., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.19095 · Cited by 54 · see citing works
Nathan, S. S., Gorlick, R. G., Bukata, S. V., Chou, A. J., Morris, C. D., Boland, P. J., Huvos, A. G., Meyers, P. A., & Healey, J. H. (2006) · Cancer · doi:10.1002/cncr.22197 · Cited by 54 · see citing works
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Yamamoto, N., & Tsuchiya, H. (2013) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2013.827171 · Cited by 54 · see citing works
Sowers, R. S., Toguchida, J., Qin, J., Meyers, P. A., Healey, J. H., Huvos, A. G., Banerjee, D., Bertino, J. R., & Gorlick, R. G. (2003) · PubMed · Cited by 53 · see citing works
Self-citationBishop, M. W., Chang, Y., Krailo, M. D., Meyers, P. A., Provisor, A. J., Schwartz, C. L., Marina, N. M., Teot, L. A., Gebhardt, M. C., Gorlick, R., et al. (2016) · Pediatric Blood & Cancer · doi:10.1002/pbc.26034 · Cited by 52 · see citing works
Self-citationFerrari, S., Zanella, L., Alberghini, M., Palmerini, E., Staals, E. L., & Bacchini, P. (2007) · Pediatric Blood & Cancer · doi:10.1002/pbc.21360 · Cited by 52 · see citing works
Jiang, W., Huang, Y., Wang, J.-P., Yu, X., & Lin-yi, Z. (2013) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2013.14.8.4615 · Cited by 52 · see citing works
Reduced folate carrier protein expression in osteosarcoma
Ifergan, I., Meller, I., Isakov, J., & Assaraf, Y. G. (2003) · Cancer · doi:10.1002/cncr.11741 · Cited by 51 · see citing works
Evolving gene therapy approaches for osteosarcoma using viral vectors: review.
Witlox, M., Lamfers, M., Wuisman, P., Curiel, D. T., & Siegal, G. P. (2007) · Bone · doi:10.1016/j.bone.2006.10.017 · Cited by 59 · see citing works
Davis, J. C., Daw, N. C., Navid, F., Billups, C. A., Wu, J., Bahrami, A., Jenkins, J. J., Snyder, S. E., Reddick, W. E., Santana, V. M., et al. (2017) · Journal of Nuclear Medicine · doi:10.2967/jnumed.117.190595 · Cited by 50 · see citing works
The role of caspases in methotrexate-induced gastrointestinal toxicity
Papaconstantinou, H. T., Xie, C., Zhang, W., Ansari, N. H., Hellmich, M. R., Townsend, C. M., & Ko, T. C. (2001) · Surgery · doi:10.1067/msy.2001.117376 · Cited by 49 · see citing works
Delaying surgery with chemotherapy for osteosarcoma of the extremities
Bielack, S., Machatschek, J.-N., Flege, S., & Jürgens, H. (2004) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.5.6.1243 · Cited by 49 · see citing works
Kudawara, I., Aoki, Y., Ueda, T., Araki, N., Naka, N., Nakanishi, H., Matsumine, A., Ieguchi, M., Mori, S., Myoui, A., et al. (2013) · Journal of Chemotherapy · doi:10.1179/1973947812y.0000000055 · Cited by 48 · see citing works
Voûte, P. A., Souhami, R. L., Nooij, M. A., Somers, R., Cortés-Funes, H., van der Eijken, J. W., Pringle, J. A. S., Hogendoorn, P. C. W., Kirkpatrick, A., Uscinska, B., et al. (1999) · Annals of Oncology · doi:10.1023/a:1008361612767 · Cited by 48 · see citing works
Kong, C., & Hansen, M. F. (2008) · Expert Opinion on Medical Diagnostics · doi:10.1517/17530050802608496 · Cited by 47 · see citing works
Dietary inorganic nitrate alleviates doxorubicin cardiotoxicity: Mechanisms and implications
Xi, L., Zhu, S., Das, A., Chen, Q., Durrant, D., Hobbs, D. C., Lesnefsky, E. J., & Kukreja, R. C. (2012) · Nitric Oxide · doi:10.1016/j.niox.2012.03.006 · Cited by 47 · see citing works
Methotrexate for high-grade osteosarcoma in children and young adults
van Dalen, E. C., van As, J. W., & de Camargo, B. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006325.pub3 · Cited by 47 · see citing works
Aung, L., Gorlick, R. G., Healey, J. H., Shi, W., Thaler, H. T., Shorter, N. A., Huvos, A. G., & Meyers, P. A. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.06.177 · Cited by 47 · see citing works
Self-citationOutcome of surgical treatment of pelvic osteosarcoma
Guo, W., Sun, X., Ji, T., & Tang, X. (2012) · Journal of Surgical Oncology · doi:10.1002/jso.23076 · Cited by 46 · see citing works
Chen, Y., Shen, Q., Gokavarapu, S., Lin, C., Yahiya, Cao, W., Chauhan, S., Liu, Z., Ji, T., & Tian, Z. (2016) · Oral Oncology · doi:10.1016/j.oraloncology.2016.04.008 · Cited by 46 · see citing works
- Authors
- Meyers, P. A., Gorlick, R., Heller, G., Casper, E., Lane, J., Huvos, A. G., & Healey, J. H.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Venue
- Journal of Clinical Oncology
- Published
- 1998-07
- Volume
- 16
- Issue
- 7
- Pages
- 2452-2458
- ISSN
- 0732-183X (ISSN-L)
- 1527-7755
- OpenAlex
- W1946181835
- Cited by
- 294
- References
- 18
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 6 · 2022: 5 · 2021: 6 · 2020: 9 · 2019: 6 · 2018: 7 · 2017: 10 · 2016: 11 · 2015: 15 · 2014: 22 · 2013: 16 · 2012: 8
- FWCI
- 7.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Oncology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Memorial Sloan-Kettering Cancer Center
- National Cancer Institute (CA-09512, T32CA009512)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoma Diagnosis and Treatment
- Health Sciences › Medicine › Rheumatology › Bone Tumor Diagnosis and Treatments
- Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
- Keywords
- osteosarcoma, neoadjuvant chemotherapy, chemotherapy intensification, cisplatin, doxorubicin, high-dose methotrexate, bleomycin, cyclophosphamide, actinomycin D, histological response, tumor necrosis, event-free survival
- MeSH terms
- Adolescent, Adult, Antineoplastic Combined Chemotherapy Protocols, Bleomycin, Bone Neoplasms, Child, Child, Preschool, Cisplatin, Cyclophosphamide, Dactinomycin, Doxorubicin, Female, Humans, Male, Methotrexate, Necrosis, Osteosarcoma, Time Factors, Treatment Outcome, Chemotherapy, Adjuvant, Disease-Free Survival
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