Cited by 294Sarcoma Diagnosis and TreatmentBone Tumor Diagnosis and TreatmentsOvarian cancer diagnosis and treatment

Intensification of preoperative chemotherapy for osteogenic sarcoma: results of the Memorial Sloan-Kettering (T12) protocol.

Meyers, P A, Gorlick, R, Heller, G, Casper, E, Lane, J, Huvos, A G, Healey, J H·1998·Journal of Clinical Oncology

Abstract

PURPOSE: It has been observed previously in osteosarcoma (OS) that the degree of necrosis of the resected primary tumor following a period of preoperative chemotherapy is predictive of subsequent event-free survival (EFS). The aim of this study was to determine if more intensive preoperative chemotherapy would increase the proportion of patients with a good histologic response and improve EFS. PATIENTS AND METHODS: Seventy-three patients with OS were treated at Memorial-Sloan Kettering Cancer Center (MSKCC) on the T12 protocol between 1986 and 1993. Patients were randomized between therapy based on the T10 protocol and therapy with more intensive preoperative chemotherapy. The more intensive preoperative regimen consisted of two courses of cisplatin (CDDP) and doxorubicin (DOX) in addition to the usual preoperative regimen of high-dose methotrexate (HD MTX) and bleomycin, cyclophosphamide, and dactinomycin (BCD). RESULTS: The regimen with more intensive preoperative chemotherapy achieved a modest increase in the proportion of patients with a good histologic response (44% with a grade III or IV histologic response v 37% in the control arm, 33% with grade IV histologic response v 13% in the control arm). EFS continued to correlate with histologic response. The actuarial 5-year EFS in patients with localized disease was 78% for the regimen with more intensive preoperative chemotherapy and 73% for the control arm. CONCLUSION: Despite modest increases in the proportion of patients with good histologic response with intensified preoperative chemotherapy, no improvement in EFS was observed.

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Crossref · 10.1200/jco.1998.16.7.2452

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17 of 17 references verified0 citation errors · 0 not checkable

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  • The dosage of chemotherapy given before surgery shifts the degree of necrosis but does not change the prognostic value of necrosis grading or influence survival.

    “The dosage of chemotherapy given before surgery shifts the degree of necrosis but it does not change the prognostic value of necrosis grading nor influence survival 119 .”

    From Osteosarcoma (2022) · cites this paper as [119]

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Authors
Meyers, P. A., Gorlick, R., Heller, G., Casper, E., Lane, J., Huvos, A. G., & Healey, J. H.
Affiliations
Memorial Sloan Kettering Cancer Center (US)
Venue
Journal of Clinical Oncology
Published
1998-07
Volume
16
Issue
7
Pages
2452-2458
ISSN
  • 0732-183X (ISSN-L)
  • 1527-7755
OpenAlex
W1946181835
Cited by
294
References
18
Citations by year
2025: 1 · 2024: 3 · 2023: 6 · 2022: 5 · 2021: 6 · 2020: 9 · 2019: 6 · 2018: 7 · 2017: 10 · 2016: 11 · 2015: 15 · 2014: 22 · 2013: 16 · 2012: 8
FWCI
7.03
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Clinical Oncology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Memorial Sloan-Kettering Cancer Center
  • National Cancer Institute (CA-09512, T32CA009512)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoma Diagnosis and Treatment
  • Health Sciences › Medicine › Rheumatology › Bone Tumor Diagnosis and Treatments
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
Keywords
osteosarcoma, neoadjuvant chemotherapy, chemotherapy intensification, cisplatin, doxorubicin, high-dose methotrexate, bleomycin, cyclophosphamide, actinomycin D, histological response, tumor necrosis, event-free survival
MeSH terms
Adolescent, Adult, Antineoplastic Combined Chemotherapy Protocols, Bleomycin, Bone Neoplasms, Child, Child, Preschool, Cisplatin, Cyclophosphamide, Dactinomycin, Doxorubicin, Female, Humans, Male, Methotrexate, Necrosis, Osteosarcoma, Time Factors, Treatment Outcome, Chemotherapy, Adjuvant, Disease-Free Survival

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