Cited by 148Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular HealthLipid metabolism and disorders

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Changes in the concentration and composition of plasma lipoproteins during the acute phase response

Carpentier, Yvon A., Scruel, Olivier·2002·Current Opinion in Clinical Nutrition and Metabolic Care

DOI 10.1097/00075197-200203000-00006

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Abstract

The acute phase reactions, associated with injury, inflammation, or sepsis, markedly affect the concentration and composition of plasma lipids and lipoproteins. Hepatic production of triglycerides and very low density lipoprotein formation are increased, but do not necessarily result in high plasma triglyceride levels. In contrast, all conditions lower plasma cholesterol by decreasing its content in both low-density and high-density lipoproteins. In addition, substantial changes in protein and lipid composition of lipoproteins are observed that may redefine the function of these particles, but also increase their atherogenic and inflammatory properties.

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Authors: Carpentier, Y. A., & Scruel, O.
Affiliations: Université Libre de Bruxelles (BE)
Corresponding author: Carpentier, Yvon A.
Venue: Current Opinion in Clinical Nutrition and Metabolic Care
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2002-03
Volume: 5
Issue: 2
Pages: 153-158
ISSN: 1363-1950 (ISSN-L)
DOI: 10.1097/00075197-200203000-00006
OpenAlex: W1974770909
Cited by: 148
References: 55
Citations by year: 2026: 1 · 2025: 2 · 2024: 5 · 2023: 8 · 2022: 5 · 2021: 10 · 2020: 3 · 2019: 5 · 2018: 2 · 2017: 13 · 2016: 7 · 2015: 8 · 2014: 5 · 2013: 9 · 2012: 6
FWCI: 1.17
Type: journal article
Language: en
Open access: closed
Locations: Current Opinion in Clinical Nutrition & Metabolic Care (publishedVersion)
PubMed (publishedVersion)
Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
Funders: National Heart, Lung, and Blood Institute (HL-40404, R01HL040404)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords: acute phase response, serum lipoproteins, lipoprotein composition, serum cholesterol, triglycerides, VLDL, low-density lipoprotein, high-density lipoprotein, inflammation, sepsis, atherogenicity
MeSH terms: Acute-Phase Reaction, Humans, Lipids, Lipoproteins, Cholesterol, HDL, Cholesterol, LDL, Lipoproteins, VLDL, Liver, Triglycerides

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Changes in the concentration and composition of plasma lipoproteins during the acute phase response

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