The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Renal Tubular Dysfunction Associated With Tenofovir Therapy: Report of 7 Cases
Abstract
We describe 7 cases of renal tubular injury in HIV-infected patients receiving an antiretroviral regimen containing tenofovir. Our patients (5 women and 2 men) developed renal tubular dysfunction, with hypophosphatemia, normoglycemic glycosuria, proteinuria, and decrease of creatinine clearance. The first biologic signs of renal toxicity were observed after duration of tenofovir treatment from 5 weeks to 16 months, and they resolved less than 4 months after discontinuation of tenofovir. Six patients had a low body weight (<60 kg). Five patients received low doses of ritonavir, and 1 received didanosine. In 5 patients, the signs resolved with the discontinuation of only the tenofovir. A renal biopsy performed in 1 patient was consistent with tubulointerstitial injury. Proximal tubulopathy appears to be a rare adverse effect of long-term tenofovir therapy. In patients with low weight or mild preexisting renal impairment, regular monitoring of tubulopathy markers could lead to early detection of this dysfunction.
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Cited by
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Metadata
- Authors
- Peyri??re, H., Reynes, J., Rouanet, I., Daniel, N., de Boever, C. M., Mauboussin, J.-M., Leray, H., Moachon, L., Vincent, D., & Salmon-C??ron, D.
- Venue
- JAIDS Journal of Acquired Immune Deficiency Syndromes
- Published
- 2004-03
- Volume
- 35
- Issue
- 3
- Pages
- 269-273
- ISSN
- 1525-4135 (ISSN-L)
- OpenAlex
- W2053407562
- Cited by
- 262
- References
- 14
- FWCI
- 15.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Renal Tubular Dysfunction Associated With Tenofovir Therapy: Report of 7 Cases. https://app.cochat.ai/papers/10.1097/00126334-200403010-00007
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- Peyri??re, H., Reynes, J., Rouanet, I., Daniel, N., de Boever, C. M., Mauboussin, J.-M., Leray, H., Moachon, L., Vincent, D., & Salmon-C??ron, D. (2004). Renal Tubular Dysfunction Associated With Tenofovir Therapy: Report of 7 Cases. JAIDS Journal of Acquired Immune Deficiency Syndromes. https://doi.org/10.1097/00126334-200403010-00007
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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