The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Incidence and risk factors for immune reconstitution inflammatory syndrome during highly active antiretroviral therapy
Abstract
BACKGROUND: There is little systematic information regarding the immune reconstitution inflammatory syndrome (IRIS). OBJECTIVE: To determine the incidence, risk factors, and long-term outcome of IRIS in HIV-infected patients receiving highly active antiretroviral therapy (HAART) who were coinfected with one of three common opportunistic pathogens. DESIGN: A retrospective cohort identified through a city-wide prospective surveillance program. METHODS: A retrospective chart review was performed for 180 HIV-infected patients who received HAART and were coinfected with Mycobacterium tuberculosis, Mycobacterium avium complex, or Cryptococcus neoformans between 1997 and 2000. Medical records were reviewed for baseline demographics, receipt and type of HAART, response to antiretroviral therapy, development of IRIS, and long-term outcome. RESULTS: In this cohort, 31.7% of patients who received HAART developed IRIS. Patients with IRIS were more likely to have initiated HAART nearer to the time of diagnosis of their opportunistic infection (P < 0.001), to have been antiretroviral naive at time of diagnosis of their opportunistic infection (P < 0.001), and to have a more rapid initial fall in HIV-1 RNA level in response to HAART (P < 0.001). CONCLUSIONS: IRIS is common among HIV-infected persons coinfected with M. tuberculosis, M. avium complex, or C. neoformans. Antiretroviral drug-naive patients who start HAART in close proximity to the diagnosis of an opportunistic infection and have a rapid decline in HIV-1 RNA level should be monitored for development of this disorder.
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Citations
Cites
The Growing Burden of Tuberculosis: Global Trends and Interactions With the HIV Epidemic
Corbett, E. L., Watt, C. J., Walker, N., Maher, D., Williams, B. G., Raviglione, M. C., & Dye, C. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.9.1009 · Cited by 2,553
Decline in the AIDS and death rates in the EuroSIDA study: an observational study
Mocroft, A., Ledergerber, B., Katlama, C., Kirk, O., Reiss, P., Monforte, A. D., Knysz, B., Dietrich, M., Phillips, A., & Lundgren, J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13802-0 · Cited by 1,241
Infections with Cryptococcus neoformans in the Acquired Immunodeficiency Syndrome
Chuck, S. L., & Sande, M. A. (1989) · New England Journal of Medicine · doi:10.1056/nejm198909213211205 · Cited by 797
SHELBURNE, S. A., HAMILL, R. J., RODRIGUEZ-BARRADAS, M. C., GREENBERG, S. B., ATMAR, R. L., MUSHER, D. M., GATHE, J. C., VISNEGARWALA, F., & TRAUTNER, B. W. (2002) · Medicine · doi:10.1097/00005792-200205000-00005 · Cited by 654
Self-citationImmune restoration disease after antiretroviral therapy
French, M. A., Price, P., & Stone, S. F. (2004) · AIDS · doi:10.1097/01.aids.0000131375.21070.06 · Cited by 651
Paradoxical Worsening of Tuberculosis Following Antiretroviral Therapy in Patients with AIDS
NARITA, M., ASHKIN, D., HOLLENDER, E. S., & PITCHENIK, A. E. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.158.1.9712001 · Cited by 608
French, M. A., Lenzo, N., John, M., Mallal, S. A., McKinnon, E. J., James, I. R., Price, P., Flexman, J. P., & Tay‐Kearney, M. (2000) · HIV Medicine · doi:10.1046/j.1468-1293.2000.00012.x · Cited by 413
DeSimone, J. A., Pomerantz, R. J., & Babinchak, T. J. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-6-200009190-00013 · Cited by 383
Race, E. M., Adelson-Mitty, J., Kriegel, G. R., Barlam, T. F., Reimann, K. A., Letvin, N. L., & Japour, A. J. (1998) · The Lancet · doi:10.1016/s0140-6736(97)04352-3 · Cited by 358
Bucy, R. P., Hockett, R. D., Derdeyn, C. A., Saag, M. S., Squires, K., Sillers, M., Mitsuyasu, R. T., & Kilby, J. M. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5863 · Cited by 329
Cited by
Perfect, J. R., Dismukes, W. E., Dromer, F., Goldman, D. L., Graybill, J. R., Hamill, R. J., Harrison, T. S., Larsen, R. A., Lortholary, O., Nguyen, M.-H., et al. (2010) · Clinical Infectious Diseases · doi:10.1086/649858 · Cited by 2,660
Self-citationMaziarz, E. K., & Perfect, J. R. (2016) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2015.10.006 · Cited by 698
Ratnam, I., Chiu, C., Kandala, N. B., & Easterbrook, P. J. (2006) · Clinical Infectious Diseases · doi:10.1086/499356 · Cited by 355
Lawn, S. D., Myer, L., Bekker, L.-G., & Wood, R. (2007) · AIDS · doi:10.1097/qad.0b013e328011efac · Cited by 343
Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein
Johnson, T. P., Patel, K., Johnson, K. R., Maric, D., Calabresi, P. A., Hasbun, R., & Nath, A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308673110 · Cited by 265
Metadata
- Authors
- Shelburne, S. A., Visnegarwala, F., Darcourt, J., Graviss, E. A., Giordano, T. P., White, A. C., & Hamill, R. J.
- Venue
- AIDS
- Published
- 2005-03-04
- Volume
- 19
- Issue
- 4
- Pages
- 399-406
- ISSN
- 0269-9370 (ISSN-L)
- OpenAlex
- W2125247264
- Cited by
- 632
- References
- 27
- FWCI
- 48.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- Shelburne, S. A., Visnegarwala, F., Darcourt, J., Graviss, E. A., Giordano, T. P., White, A. C., & Hamill, R. J. (2005). Incidence and risk factors for immune reconstitution inflammatory syndrome during highly active antiretroviral therapy. AIDS. https://doi.org/10.1097/01.aids.0000161769.06158.8a
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