The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.
Alcohol-induced neurodegeneration: when, where and why?
Abstract
This manuscript reviews the proceedings of a symposium organized by Drs. Antonio Noronha and Fulton Crews presented at the 2003 Research Society on Alcoholism meeting. The purpose of the symposium was to examine recent findings on when alcohol induced brain damage occurs, e.g., during intoxication and/or during alcohol withdrawal. Further studies investigate specific brain regions (where) and the mechanisms (why) of alcoholic neurodegeneration. The presentations were (1) Characterization of Synaptic Loss in Cerebella of Mature and Senescent Rats after Lengthy Chronic Ethanol Consumption, (2) Ethanol Withdrawal Both Causes Neurotoxicity and Inhibits Neuronal Recovery Processes in Rat Organotypic Hippocampal Cultures, (3) Binge Drinking-Induced Brain Damage: Genetic and Age Related Effects, (4) Binge Ethanol-Induced Brain Damage: Involvement of Edema, Arachidonic Acid and Tissue Necrosis Factor alpha (TNFalpha), and (5) Cyclic AMP Cascade, Stem Cells and Ethanol. Taken together these studies suggest that alcoholic neurodegeneration occurs through multiple mechanisms and in multiple brain regions both during intoxication and withdrawal.
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In the citing paper
“It has been proposed that progressive increases in ethanol consumption lead to alterations in brain structure that reduce behavioral control promoting further alcohol abuse and neurodegeneration (Crews et al., 2004).”
From Impulsivity, frontal lobes and risk for addiction (2009) · cites this paper as Crews et al., 2004
In the citing paper
“Basic animal model studies have established that high blood levels of alcohol can induce brain damage (Crews et al., 2004).”
From Impulsivity, frontal lobes and risk for addiction (2009) · cites this paper as Crews et al., 2004
Citations
Cites
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Research works printed but not linked: 8
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- Crews FT, 1993, Alcohol‐Induced Brain Damage, 355
- Hamelink C, 1998, Neither NMDA nor L‐type calcium channel blockade prevent alcohol‐induced neurodegeneration, Alcohol Clin Exp Res, 22, 64A
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Cited by
Sorted by citations
Adolescent cortical development: A critical period of vulnerability for addiction
Crews, F., He, J., & Hodge, C. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.12.001 · Cited by 1,091
“Studies of binge drinking induced brain damage in rats have found that adolescent forebrain is particularly sensitive to ethanol induced neurodegeneration (Crews et al., 2004).”
BackgroundImpulsivity, frontal lobes and risk for addiction
Crews, F. T., & Boettiger, C. A. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.04.018 · Cited by 679
“Basic animal model studies have established that high blood levels of alcohol can induce brain damage (Crews et al., 2004).”
BackgroundInfluentialMechanisms of Neurodegeneration and Regeneration in Alcoholism
Crews, F. T., & Nixon, K. (2008) · Alcohol and Alcoholism · doi:10.1093/alcalc/agn079 · Cited by 596
Crews, F. T., Bechara, R. I., Brown, L. A. S., Guidot, D. M., Mandrekar, P., Oak, S. A., Qin, L., Szabó, G., Wheeler, M. D., & Zou, J. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00084.x · Cited by 418
Pascual, M., Blanco, A. M., Cauli, O., Miñarro, J., & Guerri, C. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05298.x · Cited by 385
“During adolescence, the brain undergoes neuromaturation, which involves changes in neurotransmission and plasticity that are associated with structural modifications in some brain regions, including the hippocampus, prefrontal cortex and the limbic system structures (Dahl, 2004).”
Background
Metadata
- Authors
- Crews, F. T., Collins, M. A., Dlugos, C., Littleton, J., Wilkins, L., Neafsey, E. J., Pentney, R., Snell, L. D., Tabakoff, B., Zou, J., & Noronha, A.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Crews, Fulton T.
- Venue
- Alcoholism Clinical and Experimental Research
- Publisher
- Wiley
- Published
- 2004-02
- Volume
- 28
- Issue
- 2
- Pages
- 350-364
- ISSN
- 0145-6008 (ISSN-L)
- 1530-0277
- OpenAlex
- W2086810773
- Cited by
- 181
- References
- 98
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 5 · 2023: 7 · 2022: 3 · 2021: 9 · 2020: 9 · 2019: 11 · 2018: 9 · 2017: 7 · 2016: 8 · 2015: 12 · 2014: 14 · 2013: 6 · 2012: 9
- FWCI
- 4.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Alcoholism Clinical and Experimental Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Alcoholism and Thiamine Deficiency
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- ethanol neurotoxicity, alcohol withdrawal, binge drinking, chronic alcohol consumption, hippocampal cultures, neuronal recovery, cerebral edema, arachidonic acid, TNF-α, cyclic AMP, stem cells, aging, genetic susceptibility
- MeSH terms
- Alcohol Drinking, Ethanol, Animals, Cell Differentiation, Humans, Nerve Degeneration, Neurons, Societies, Medical, United States
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