Cited by 181Alcoholism and Thiamine DeficiencyAlcohol Consumption and Health EffectsNeuroscience and Neuropharmacology Research

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Alcohol-induced neurodegeneration: when, where and why?

Crews, Fulton T., Collins, Michael A., Dlugos, Cynthia, Littleton, John, Wilkins, Lincoln, Neafsey, Edward J., Pentney, Roberta, Snell, Lawrence D., Tabakoff, Boris, Zou, Jian, Noronha, Antonio·2004·Alcoholism Clinical and Experimental Research

DOI 10.1097/01.alc.0000113416.65546.01

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Abstract

This manuscript reviews the proceedings of a symposium organized by Drs. Antonio Noronha and Fulton Crews presented at the 2003 Research Society on Alcoholism meeting. The purpose of the symposium was to examine recent findings on when alcohol induced brain damage occurs, e.g., during intoxication and/or during alcohol withdrawal. Further studies investigate specific brain regions (where) and the mechanisms (why) of alcoholic neurodegeneration. The presentations were (1) Characterization of Synaptic Loss in Cerebella of Mature and Senescent Rats after Lengthy Chronic Ethanol Consumption, (2) Ethanol Withdrawal Both Causes Neurotoxicity and Inhibits Neuronal Recovery Processes in Rat Organotypic Hippocampal Cultures, (3) Binge Drinking-Induced Brain Damage: Genetic and Age Related Effects, (4) Binge Ethanol-Induced Brain Damage: Involvement of Edema, Arachidonic Acid and Tissue Necrosis Factor alpha (TNFalpha), and (5) Cyclic AMP Cascade, Stem Cells and Ethanol. Taken together these studies suggest that alcoholic neurodegeneration occurs through multiple mechanisms and in multiple brain regions both during intoxication and withdrawal.

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Sorted by citations

Adolescent cortical development: A critical period of vulnerability for addiction
Crews, F., He, J., & Hodge, C. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.12.001 · Cited by 1,091
“Studies of binge drinking induced brain damage in rats have found that adolescent forebrain is particularly sensitive to ethanol induced neurodegeneration (Crews et al., 2004).”
Background
Impulsivity, frontal lobes and risk for addiction
Crews, F. T., & Boettiger, C. A. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.04.018 · Cited by 679
“Basic animal model studies have established that high blood levels of alcohol can induce brain damage (Crews et al., 2004).”
BackgroundInfluential
Mechanisms of Neurodegeneration and Regeneration in Alcoholism
Crews, F. T., & Nixon, K. (2008) · Alcohol and Alcoholism · doi:10.1093/alcalc/agn079 · Cited by 596
Cytokines and Alcohol
Crews, F. T., Bechara, R. I., Brown, L. A. S., Guidot, D. M., Mandrekar, P., Oak, S. A., Qin, L., Szabó, G., Wheeler, M. D., & Zou, J. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00084.x · Cited by 418
Intermittent ethanol exposure induces inflammatory brain damage and causes long‐term behavioural alterations in adolescent rats
Pascual, M., Blanco, A. M., Cauli, O., Miñarro, J., & Guerri, C. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05298.x · Cited by 385
“During adolescence, the brain undergoes neuromaturation, which involves changes in neurotransmission and plasticity that are associated with structural modifications in some brain regions, including the hippocampus, prefrontal cortex and the limbic system structures (Dahl, 2004).”
Background

See all 181

Authors: Crews, F. T., Collins, M. A., Dlugos, C., Littleton, J., Wilkins, L., Neafsey, E. J., Pentney, R., Snell, L. D., Tabakoff, B., Zou, J., & Noronha, A.
Affiliations: University of North Carolina at Chapel Hill (US)
Corresponding author: Crews, Fulton T.
ORCID: Crews, Fulton T.
Collins, Michael A.
Tabakoff, Boris
Zou, Jian
Venue: Alcoholism Clinical and Experimental Research
Publisher: Wiley
Published: 2004-02
Volume: 28
Issue: 2
Pages: 350-364
ISSN: 0145-6008 (ISSN-L)
1530-0277
DOI: 10.1097/01.alc.0000113416.65546.01
OpenAlex: W2086810773
Cited by: 181
References: 98
Citations by year: 2026: 3 · 2025: 7 · 2024: 5 · 2023: 7 · 2022: 3 · 2021: 9 · 2020: 9 · 2019: 11 · 2018: 9 · 2017: 7 · 2016: 8 · 2015: 12 · 2014: 14 · 2013: 6 · 2012: 9
FWCI: 4.92
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 822 d)
Locations: Alcoholism Clinical and Experimental Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Alcoholism and Thiamine Deficiency
Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: ethanol neurotoxicity, alcohol withdrawal, binge drinking, chronic alcohol consumption, hippocampal cultures, neuronal recovery, cerebral edema, arachidonic acid, TNF-α, cyclic AMP, stem cells, aging, genetic susceptibility
MeSH terms: Alcohol Drinking, Ethanol, Animals, Cell Differentiation, Humans, Nerve Degeneration, Neurons, Societies, Medical, United States

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