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A Randomized Controlled Trial of Ginger to Treat Nausea and Vomiting in Pregnancy
Abstract
OBJECTIVES: To estimate whether the use of ginger to treat nausea or vomiting in pregnancy is equivalent to pyridoxine hydrochloride (vitamin B6). METHODS: A randomized, controlled equivalence trial involving 291 women less than 16 weeks pregnant was undertaken at a teaching hospital in Australia. Women took 1.05 g of ginger or 75 mg of vitamin B6 daily for 3 weeks. Differences from baseline in nausea and vomiting scores were estimated for both groups at days 7, 14, and 21. RESULTS: Ginger was equivalent to vitamin B6 in reducing nausea (mean difference 0.2, 90% confidence interval [CI] -0.3, 0.8), retching (mean difference 0.3; 90% CI -0.0, 0.6) and vomiting (mean difference 0.5; 90% CI 0.0, 0.9), averaged over time, with no evidence of different effects at the 3 time points. CONCLUSION: For women looking for relief from their nausea, dry retching, and vomiting, the use of ginger in early pregnancy will reduce their symptoms to an equivalent extent as vitamin B6. LEVEL OF EVIDENCE: I
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Cited by
Interventions for nausea and vomiting in early pregnancy
Matthews, A., Haas, D. M., O'Mathúna, D. P., & Dowswell, T. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007575.pub4 · Cited by 339
A review of the gastroprotective effects of ginger (Zingiber officinale Roscoe)
Haniadka, R., Saldanha, E., Sunita, V., Palatty, P. L., Fayad, R., & Baliga, M. S. (2013) · Food & Function · doi:10.1039/c3fo30337c · Cited by 249
Ginger on Human Health: A Comprehensive Systematic Review of 109 Randomized Controlled Trials
Anh, N. H., Kim, S. J., Long, N. P., Min, J. E., Yoon, Y. C., Lee, E. G., Kim, M., Kim, T. J., Yang, Y. Y., Son, E. Y., et al. (2020) · Nutrients · doi:10.3390/nu12010157 · Cited by 227
Ginger in gastrointestinal disorders: A systematic review of clinical trials
Nikkhah Bodagh, M., Maleki, I., & Hekmatdoost, A. (2019) · Food Science & Nutrition · doi:10.1002/fsn3.807 · Cited by 221
Ginger in the Prevention of Nausea and Vomiting: A Review
Palatty, P. L., Haniadka, R., Valder, B., Arora, R., & Baliga, M. S. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.553751 · Cited by 156
Metadata
- Authors
- Smith, C., Crowther, C., Willson, K., Hotham, N., & McMillian, V.
- Venue
- Obstetrics & Gynecology
- Published
- 2004-04
- Volume
- 103
- Issue
- 4
- Pages
- 639-645
- ISSN
- 0029-7844 (ISSN-L)
- OpenAlex
- W2145398895
- Cited by
- 179
- References
- 0
- FWCI
- 8.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- Smith, C., Crowther, C., Willson, K., Hotham, N., & McMillian, V. (2004). A Randomized Controlled Trial of Ginger to Treat Nausea and Vomiting in Pregnancy. Obstetrics & Gynecology. https://doi.org/10.1097/01.aog.0000118307.19798.ec
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