The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
TGF-ß Signaling in Renal Disease
Abstract
Since discovery over a decade ago of a role for the cytokine TGF-beta as key mediator of glomerular and tubulointerstitial pathobiology in chronic kidney diseases, studies of TGF-beta signaling in the kidney have focused on the molecular biology of fibrogenesis. In recent years, glomerular and tubular epithelial cell apoptosis and cellular transdifferentiation have been proposed as putative primary pathomechanisms that may underlie progression of renal disease. This review describes evidence in support of nonlinear models and functional roles of TGF-beta signaling in mediating apoptosis and epithelial-to-mesenchymal transdifferentiation (EMT) in chronic progressive renal disease. Emphasis is placed on cell context-dependent models of TGF-beta signaling providing a conceptual framework to consolidate seemingly distinct pathomechanisms of progression of glomerular and tubulointerstitial disease.
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Citations
Cites
TGF-β Signaling in Tumor Suppression and Cancer Progression
Derynck, R., Akhurst, R. J., & Balmain, A. (2001) · Nature Genetics · doi:10.1038/ng1001-117 · Cited by 2,275
Cell death and control of cell survival in the oligodendrocyte lineage
Barres, B. A., Hart, I. K., Coles, H. S. R., Burne, J. F., Voyvodic, J. T., Richardson, W. D., & Raff, M. C. (1992) · Cell · doi:10.1016/0092-8674(92)90531-g · Cited by 1,345
Cited by
TGF-β: the master regulator of fibrosis
Meng, X.-M., Nikolic-Paterson, D. J., & Lan, H. Y. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.48 · Cited by 3,528
Kang, H. M., Ahn, S. H., Choi, P., Ko, Y.-A., Han, S. H., Chinga, F., Park, A. S. D., Tao, J., Sharma, K., Pullman, J., et al. (2015) · Nature Medicine · doi:10.1038/nm.3762 · Cited by 1,555
New Insights into Epithelial-Mesenchymal Transition in Kidney Fibrosis
Liu, Y. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008121226 · Cited by 870
TGF-β1 induces human alveolar epithelial to mesenchymal cell transition (EMT)
Kasai, H., Allen, J. T., Mason, R. M., Kamimura, T., & Zhang, Z. (2005) · Respiratory Research · doi:10.1186/1465-9921-6-56 · Cited by 744
TGF-β/Smad signaling in renal fibrosis
Meng, X.-M., Tang, P. M.-K., Li, J., & Lan, H. Y. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00082 · Cited by 666
Metadata
- Authors
- Bo[Combining Diaeresis]ttinger, E. P., & Bitzer, M.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2002-10
- Volume
- 13
- Issue
- 10
- Pages
- 2600-2610
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2132803823
- Cited by
- 711
- References
- 2
- FWCI
- 8.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bo[Combining Diaeresis]ttinger, E. P., & Bitzer, M. (2002). TGF-ß Signaling in Renal Disease. Journal of the American Society of Nephrology. https://doi.org/10.1097/01.asn.0000033611.79556.ae
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