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Cited by 1,345Neurogenesis and neuroplasticity mechanismsCell death mechanisms and regulationDevelopmental Biology and Gene Regulation

Cell death and control of cell survival in the oligodendrocyte lineage

Barres, B.A., Hart, I.K., Coles, H.S.R., Burne, J.F., Voyvodic, J.T., Richardson, W.D., Raff, M.C.·1992·Cell
DOI 10.1016/0092-8674(92)90531-g
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Abstract

Dead cells are observed in many developing animal tissues, but the causes of these normal cell deaths are mostly unknown. We show that about 50% of oligodendrocytes normally die in the developing rat optic nerve, apparently as a result of a competition for limiting amounts of survival signals. Both platelet-derived growth factor and insulin-like growth factors are survival factors for newly formed oligodendrocytes and their precursors in culture. Increasing platelet-derived growth factor in the developing optic nerve decreases normal oligodendrocyte death by up to 90% and doubles the number of oligodendrocytes in 4 days. These results suggest that a requirement for survival signals is more general than previously thought and that some normal cell deaths in nonneural tissues may also reflect competition for survival factors.

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Crossref · 10.1016/0092-8674(92)90531-g

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  • Approximately 50% of OLs in the perinatal optic nerve die soon after they are formed.

    “It has been estimated that ∼50% of OLs in the perinatal optic nerve die soon after they are formed (Barres et al., 1992).”

    From Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling (2013) · cites this paper as Barres et al., 1992

  • IGF-1 plays a crucial role in oligodendrocyte differentiation, survival, and myelination.

    “IGF-1 is believed to play a crucial role in oligodendrocyte differentiation, survival, and myelination (Mozell and Mcmorris, 1991; Barres et al., 1992, 1993; Goddard et al., 1999; Ye and D'Ercole, 1999).”

    From Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned (2014) · cites this paper as Barres et al., 1992

  • The appearance of PAM coincides with the onset of myelination, when many newly formed oligodendrocytes die.

    “The timing of their appearance coincides with the onset of myelination, during which large numbers of newly formed oligodendrocytes die (Barres et al., 1992; Trapp et al., 1997).”

    From Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing (2019) · cites this paper as Barres et al., 1992

  • Oligodendrocyte progenitor cells used for biotinylation assays, 2-deoxyglucose uptake, or lactate release were purified to 98.2% ± 0.3% by negative selection immunopanning.

    “OPCs utilized for biotinylation assays, 2-deoxyglucose uptake, or lactate release were further purified to 98.2% ± 0.3% by negative selection immunopanning (Barres et al., 1992).”

    From Oligodendroglial NMDA receptors regulate glucose import and axonal energy metabolism (2016) · cites this paper as Barres et al., 1992

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Authors
Barres, B. A., Hart, I. K., Coles, H. S. R., Burne, J. F., Voyvodic, J. T., Richardson, W. D., & Raff, M. C.
Affiliations
University College London (GB)
ORCID
Venue
Cell
Publisher
Elsevier BV
Published
1992-07
Volume
70
Issue
1
Pages
31-46
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/0092-8674(92)90531-g
OpenAlex
W2081560586
Cited by
1,345
References
116
Citations by year
2026: 13 · 2025: 14 · 2024: 20 · 2023: 15 · 2022: 16 · 2021: 28 · 2020: 27 · 2019: 29 · 2018: 28 · 2017: 21 · 2016: 16 · 2015: 27 · 2014: 22 · 2013: 33 · 2012: 24
FWCI
25.14
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
oligodendrocyte lineage, cell death, cell survival, optic nerve development, platelet-derived growth factor, insulin-like growth factor, survival signaling, oligodendrocyte precursor cells, developmental cell death
MeSH terms
Animals, Cell Communication, Cell Survival, Cells, Cultured, Insulin-Like Growth Factor I, Insulin-Like Growth Factor II, Oligodendroglia, Optic Nerve, Platelet-Derived Growth Factor, Rats, Inbred Strains, Rats

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