Cited by 195Renin-Angiotensin System StudiesEicosanoids and Hypertension PharmacologyNitric Oxide and Endothelin Effects

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

A Mouse Model of Angiotensin II Slow Pressor Response: Role of Oxidative Stress

Kawada, Noritaka, Imai, Enyu, Karber, Alexsander, Welch, William J., Wilcox, Christopher S.·2002·Journal of the American Society of Nephrology

DOI 10.1097/01.asn.0000035087.11758.ed

Open this paper in CoChat — free account

Abstract

ABSTRACT. The slow pressor response to prolonged infusions of angiotensin II (AngII) entails a delayed rise in BP. This study investigated the hypothesis that the response depends on the generation of oxidative stress. The BP and renal functional response of mice to graded doses (200, 400, and 1000 ng. kg(-1). min(-1)) of subcutaneously infused AngII was studied. The SBP of conscious mice increased by day 3 at AngII1000 but showed a delayed rise by days 9 to 13 (slow pressor response) at the lower rates of AngII infusion. By day 13, there was a graded increase in SBP with the rate of AngII infusion (Vehicle, -2.6 +/- 2.6%; AngII200, +14.1 +/- 5.0%; AngII400, +31.9 +/- 1.9%; AngII1000, +43.2 +/- 5.5%). The MAP measured under anesthesia rose significantly (P < 0.001) with AngII400 at 14 d (Vehicle, 85 +/- 2 mmHg; AngII400, 100 +/- 3 mmHg). When studied at day 6, the MAP of AngII400 rats was not elevated (88 +/- 2 mmHg; NS versus vehicle), yet the GFR was higher (1.05 +/- 0.05 versus 1.25 +/- 0.05 ml. min(-1). g(-1); P < 0.05) accompanied by an increase in the filtration fraction (FF) (28.8 +/- 1.2 versus 37.2 +/- 0.8%; P < 0.001). From day 6 through day 14, the MAP had increased (P < 0.01) in AngII400, accompanied by a significant reduction in GFR to 1.05 +/- 0.04 ml. min(-1). g(-1) (P < 0.01) and elevation of renal vascular resistance (RVR) (day 6 versus day 14, 15.3 +/- 0.6 versus 19.2 +/- 1.2 mmHg. ml(-1). min(-1). g(-1); P < 0.05). Renal excretion of 8-iso PGF(2alpha) was increased in AngII400 group at day 12 (2.52 +/- 0.35 versus 5.85 +/- 0.78 pg. day(-1); P < 0.01). The permeant superoxide dismutase mimetic tempol reduced the effects of AngII400 on the SBP (-1.7 +/- 5.8%; P < 0.01), the MAP (87 +/- 4 mmHg; P < 0.01), and the RVR (15.2 +/- 0.5 mmHg. ml(-1). min(-1). g(-1); P < 0.05) at day 14 and the renal 8-iso PGF(2alpha) excretion (3.53 +/- 0.71 pg. d(-1); P < 0.05) at day 12. It is concluded that the AngII infused mouse is a valid model for the slow pressor response. There is an early rise in GFR and FF, consistent with increased postglomerular vascular resistance and a late rise in RVR with a fall in GFR, consistent with increased preglomerular vascular resistance that is accompanied by a rise in BP. There is evidence of increased oxidative stress that is implicated in the increase in the BP and RVR in this model.

Integrity signals

Registry

Crossref · 10.1097/01.asn.0000035087.11758.ed

Cites

47 of 47 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.
Rajagopalan, S., Kurz, S. D., Münzel, T. F., Tarpey, M. M., Freeman, B. Α., Griendling, K. K., & Harrison, D. G. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118623 · Cited by 2,467
A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism.
Morrow, J. D., Hill, K. E., Burk, R. F., Nammour, T., Badr, K. F., & Roberts, L. J. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.23.9383 · Cited by 1,898
A Light and Electron Microscopic Study
Schochet, S. S., McCermick, W. F., & F, G. F. (1976) · Cited by 1,642
Role of Superoxide in Angiotensin II–Induced but Not Catecholamine-Induced Hypertension
Laursen, J. B., Rajagopalan, S., Galis, Z. S., Tarpey, M. M., Freeman, B. Α., & Harrison, D. G. (1997) · Circulation · doi:10.1161/01.cir.95.3.588 · Cited by 820
Normalization of Blood Pressure and Renal Vascular Resistance in SHR With a Membrane-Permeable Superoxide Dismutase Mimetic
Schnackenberg, C. G., Welch, W. J., & Wilcox, C. S. (1998) · Hypertension · doi:10.1161/01.hyp.32.1.59 · Cited by 498
Self-citation
Isoprostanes: Formation, Analysis and Use As Indices of Lipid Peroxidation in Vivo
Lawson, J. A., FitzGerald, G. A., & Rokach, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.35.24441 · Cited by 381
Expression and Cellular Localization of Classic NADPH Oxidase Subunits in the Spontaneously Hypertensive Rat Kidney
Chabrashvili, T., Tojo, A., Onozato, M. L., Kitiyakara, C., Quinn, M. T., Fujita, T., Welch, W. J., & Wilcox, C. S. (2002) · Hypertension · doi:10.1161/hy0202.103264 · Cited by 377
Self-citation
Two-Week Administration of Tempol Attenuates Both Hypertension and Renal Excretion of 8-Iso Prostaglandin F 2α
Schnackenberg, C. G., & Wilcox, C. S. (1999) · Hypertension · doi:10.1161/01.hyp.33.1.424 · Cited by 375
Self-citation
Angiotensin II–Induced Hypertension Accelerates the Development of Atherosclerosis in ApoE-Deficient Mice
Weiss, D., Kools, J. J., & Taylor, W. R. (2001) · Circulation · doi:10.1161/01.cir.103.3.448 · Cited by 370
Role of Angiotensin and Oxidative Stress in Essential Hypertension
Romero, J. C., & Reckelhoff, J. F. (1999) · Hypertension · doi:10.1161/01.hyp.34.4.943 · Cited by 358

Show all 47 references

Sorted by citations

Items 101–195 of 195

Mixed Cerebrovascular Disease and the Future of Stroke Prevention
Fisher, M., Vasilevko, V., & Cribbs, D. H. (2012) · Translational Stroke Research · doi:10.1007/s12975-012-0185-6 · Cited by 37
Cyclooxygenase-1–Deficient Mice Have High Sleep-to-Wake Blood Pressure Ratios and Renal Vasoconstriction
Kawada, N., Solis, G., Ivey, N., Connors, S. G., Dennehy, K., Modlinger, P., Hamel, R., Kawada, J. T., Imai, E., Langenbach, R. I., et al. (2005) · Hypertension · doi:10.1161/01.hyp.0000166141.69081.80 · Cited by 33
Self-citation
Experimental TET2 Clonal Hematopoiesis Predisposes to Renal Hypertension Through an Inflammasome-Mediated Mechanism
Polizio, A. H., Marino, L., Min, K.-D., Yura, Y., Rolauer, L., Cochran, J. D., Evans, M. A., Park, E., Doviak, H., Miura‐Yura, E., et al. (2024) · Circulation Research · doi:10.1161/circresaha.124.324492 · Cited by 33
Deficiency of Nox2 prevents angiotensin II-induced inward remodeling in cerebral arterioles
Chan, S., & Baumbach, G. L. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00133 · Cited by 32
The role of aldosterone in mediating the dependence of angiotensin hypertension on IL-6
Sturgis, L. C., Cannon, J. G., Schreihofer, D. A., & Brands, M. W. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90995.2008 · Cited by 33
Roles of vasoconstrictor prostaglandins, COX-1 and -2, and AT1, AT2, and TP receptors in a rat model of early 2K,1C hypertension
Welch, W. J., Patel, K., Modlinger, P., Mendonca, M., Kawada, N., Dennehy, K., Aslam, S., & Wilcox, C. S. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00748.2007 · Cited by 32
Self-citation
Impaired Endothelial Function and Microvascular Asymmetrical Dimethylarginine in Angiotensin II–Infused Rats
Wang, D., Luo, Z., Wang, X., José, P. A., Falck, J. R., Welch, W. J., Aslam, S., Teerlink, T., & Wilcox, C. S. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.157115 · Cited by 32
Self-citation
The regulation of blood perfusion in the renal cortex and medulla by reactive oxygen species and nitric oxide in the anaesthetised rat
Ahmeda, A. F., & Johns, E. J. (2011) · Acta Physiologica · doi:10.1111/j.1748-1716.2011.02346.x · Cited by 31
ERβ Selective Agonist Inhibits Angiotensin-Induced Cardiovascular Pathology in Female Mice
Pedram, A., Razandi, M., Korach, K. S., Narayanan, R., Dalton, J. T., & Levin, E. R. (2013) · Endocrinology · doi:10.1210/en.2013-1358 · Cited by 30
Efficacy of the superoxide dismutase mimetic tempol in animal hypertension models
Dornas, W. C., Silva, M., Tavares, R. L. D. O., de Lima, W. G., dos Santos, R. C., Pedrosa, M. L., & Silva, M. E. (2014) · Journal of Hypertension · doi:10.1097/hjh.0000000000000422 · Cited by 30
Role of Kidneys in Sex Differences in Angiotensin II–Induced Hypertension
Wang, L., Wang, X., Qu, H. Y., Jiang, S., Zhang, J., Fu, L., Buggs, J., Pang, B., Wei, J., & Liu, R. (2017) · Hypertension · doi:10.1161/hypertensionaha.117.10052 · Cited by 29
Endothelin-1-Induced Microvascular ROS and Contractility in Angiotensin-II-Infused Mice Depend on COX and TP Receptors
Wilcox, C. S., Wang, C., & Wang, D. (2019) · Antioxidants · doi:10.3390/antiox8060193 · Cited by 29
Self-citation
Low Dose Chronic Angiotensin II Induces Selective Senescence of Kidney Endothelial Cells
Khan, I., Schmidt, M. O., Kallakury, B., Jain, S. S., Mehdikhani, S., Levi, M., Mendonca, M., Welch, W. J., Riegel, A. T., Wilcox, C. S., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.782841 · Cited by 28
Self-citation
Superoxide Enhances Ca2+Entry Through L-Type Channels in the Renal Afferent Arteriole
Vogel, P. A., Yang, X., Moss, N., & Arendshorst, W. J. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.05274 · Cited by 29
Sex-Specific Modulation of Blood Pressure and the Renin-Angiotensin System by ACE (Angiotensin-Converting Enzyme) 2
Ji, H., de Souza, A. M. A., Bajaj, B., Zheng, W., Wu, X., Speth, R. C., & Sandberg, K. L. (2020) · Hypertension · doi:10.1161/hypertensionaha.120.15276 · Cited by 29
H2S as a possible therapeutic alternative for the treatment of hypertensive kidney injury
Dugbartey, G. J. (2017) · Nitric Oxide · doi:10.1016/j.niox.2017.01.002 · Cited by 27
Angiotensin II and oxidative stress: an unholy alliance.
Ritz, E., & Haxsen, V. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000096784.86791.21 · Cited by 33
Renal NOXA1/NOX1 Signaling Regulates Epithelial Sodium Channel and Sodium Retention in Angiotensin II-induced Hypertension
Vendrov, A. E., Stevenson, M., Lozhkin, A. P., Hayami, T., Holland, N. A., Yang, X., Moss, N., Pan, H., Wickline, S. A., Stockand, J. D., et al. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0047 · Cited by 26
β1 Receptors Protect the Renal Afferent Arteriole of Angiotensin-Infused Rabbits from Norepinephrine-Induced Oxidative Stress
Wang, D., José, P. A., & Wilcox, C. S. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006030212 · Cited by 26
Self-citation
NO-independent mechanism mediates tempol-induced renal vasodilation in SHR
de Richelieu, L. T., Sørensen, C. M., Holstein‐Rathlou, N., & Salomonsson, M. (2005) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00116.2005 · Cited by 25
Epoxyeicosatrienoic acid analog attenuates the development of malignant hypertension, but does not reverse it once established
Jíchová, Š., Kopkan, L., Husková, Z., Doleželová, Š., Neckář, J., Kujal, P., Vernerová, Z., Kramer, H. J., Sadowski, J., Kompanowska‐Jezierska, E., et al. (2016) · Journal of Hypertension · doi:10.1097/hjh.0000000000001029 · Cited by 25
Measurement of Glomerular Filtration Rate in Conscious Mice
Qi, Z., & Breyer, M. D. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-352-3_5 · Cited by 23
Kidney oxygen consumption, carbonic anhydrase, and proton secretion
Deng, A., Miracle, C. M., Lortie, M. J., Satriano, J. A., Gabbai, F. B., Munger, K. A., Thomson, S. C., & Blantz, R. C. (2005) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00343.2005 · Cited by 24
Acute effects of the superoxide dismutase mimetic tempol on split kidney function in two-kidney one-clip hypertensive rats
Guron, G., Grimberg, E., Basu, S., & Herlitz, H. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000200511.02700.99 · Cited by 24
Etiology and Management of Hypertension in Chronic Kidney Disease
Andersen, M. J., & Agarwal, R. (2005) · Medical Clinics of North America · doi:10.1016/j.mcna.2004.12.001 · Cited by 24
Subcellular compartmentalization of proximal Gαq-receptor signaling produces unique hypertrophic phenotypes in adult cardiac myocytes
Dahl, E. F., Wu, S. C., Healy, C. L., Harsch, B. A., Shearer, G. C., & O’Connell, T. D. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.002283 · Cited by 23
Sex differences in NMDA GluN1 plasticity in rostral ventrolateral medulla neurons containing corticotropin-releasing factor type 1 receptor following slow-pressor angiotensin II hypertension
Kempen, T. A. V., Dodos, M., Woods, C., Marques-Lopes, J., Justice, N. J., Iadecola, C., Pickel, V. M., Glass, M. J., & Milner, T. A. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.08.029 · Cited by 22
Reduction of oxidative stress does not attenuate the development of angiotensin II-dependent hypertension in Ren-2 transgenic rats
Kopkan, L., Husková, Z., Vaňourková, Z., Thumová, M., Škaroupková, P., Malý, J., Kramer, H. J., Dvořák, P., & Červenka, L. (2009) · Vascular Pharmacology · doi:10.1016/j.vph.2009.06.001 · Cited by 21
Association between xanthine dehydrogenase tag single nucleotide polymorphisms and essential hypertension
Wu, B., Hao, Y., Shi, J. P., Geng, N., Li, T., Chen, Y., Sun, Z., Zheng, L., LI, H., Li, N., et al. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4135 · Cited by 21
Modeling Superimposed Preeclampsia Using Ang II (Angiotensin II) Infusion in Pregnant Stroke-Prone Spontaneously Hypertensive Rats
Morgan, H. L., Butler, E., Ritchie, S., Herse, F., Dechend, R., Beattie, E. C., McBride, M., & Graham, D. (2018) · Hypertension · doi:10.1161/hypertensionaha.118.10935 · Cited by 21
Angiotensin II and Cardiovascular Disease: Balancing Pathogenic and Protective Pathways
Bayraktutan, U. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47070501 · Cited by 22
Impaired EphA4 signaling leads to congenital hydronephrosis, renal injury, and hypertension
Sällström, J., Peuckert, C., Gao, X., Larsson, E., Nilsson, A., Jensen, B. L., Onozato, M. L., Persson, A. E. G., Kullander, K., & Carlström, M. (2013) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00694.2012 · Cited by 19
Treatment with valsartan stimulates endothelial progenitor cells and renal label-retaining cells in hypertensive rats
Yoshida, Y., Fukuda, N., Maeshima, A., Yamamoto, C., Matsumoto, T., Ueno, T., Nojima, Y., Matsumoto, K., & Soma, M. (2010) · Journal of Hypertension · doi:10.1097/hjh.0b013e32834000e2 · Cited by 18
DPP4 inhibition mitigates ANG II-mediated kidney immune activation and injury in male mice
Nistala, R., Meuth, A. I., Smith, C., An, J., Habibi, J., Hayden, M. R., Johnson, M. S., Aroor, A. R., Whaley‐Connell, A. T., Sowers, J. R., et al. (2021) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00565.2020 · Cited by 18
3,3′,4′,5,7-Pentamethylquercetin reduces angiotensin II-induced cardiac hypertrophy and apoptosis in rats
Mao, Z., Liang, Y., Du, X., & Sun, Z. (2009) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y09-069 · Cited by 18
Antioxidative and blood pressure-lowering effects of Scurrula atropurpurea on deoxycorticosterone acetate–salt hypertensive rats
Athiroh, N., Permatasari, N., Sargowo, D., & Widodo, M. A. (2014) · Biomarkers and Genomic Medicine · doi:10.1016/j.bgm.2014.01.001 · Cited by 17
Adenosine A1-receptor knockout mice have a decreased blood pressure response to low-dose ANG II infusion
Lee, D. L., Bell, T. D., Bhupatkar, J., Solis, G., & Welch, W. J. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00116.2012 · Cited by 18
Self-citation
Context-dependent effects of SOCS3 in angiotensin II-induced vascular dysfunction and hypertension in mice: mechanisms and role of bone marrow-derived cells
Li, Y., Kinzenbaw, D. A., Modrick, M. L., Pewe, L. L., & Faraci, F. M. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00204.2016 · Cited by 17
Vascular and Central Activation of Peroxisome Proliferator–Activated Receptor-β Attenuates Angiotensin II–Induced Hypertension: Role of RGS-5
Romero, M., Jiménez, R., Toral, M., Gomez, E. L., Gómez‐Guzmán, M., Sánchez, M., Zarzuelo-Romero, M. J., Rodríguez‐Gómez, I., Rath, G., Tamargo, J. L., et al. (2016) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.233106 · Cited by 17
Cardiomyocyte calcineurin is required for the onset and progression of cardiac hypertrophy and fibrosis in adult mice
Martı́nez-Martı́nez, S., Lozano‐Vidal, N., López-Maderuelo, D., Jiménez‐Borreguero, L. J., Armesilla, A. L., & Redondo, J. M. (2018) · FEBS Journal · doi:10.1111/febs.14718 · Cited by 17
Sacubitril/Valsartan Inhibits Cardiomyocyte Hypertrophy in Angiotensin II-Induced Hypertensive Mice Independent of a Blood Pressure-Lowering Effect
Tashiro, K., Kuwano, T., Ideishi, A., Morita, H., Idemoto, Y., Goto, M., Suematsu, Y., & Miura, S.-I. (2020) · Cardiology Research · doi:10.14740/cr1137 · Cited by 18
Vascular wall regulator of G-protein signalling-1 (RGS-1) is required for angiotensin II–mediated blood pressure control
Patel, J., Chuaiphichai, S., Douglas, G., Gorvin, C. M., & Channon, K. M. (2018) · Vascular Pharmacology · doi:10.1016/j.vph.2018.04.002 · Cited by 17
The role of IL-6 in the physiologic versus hypertensive blood pressure actions of angiotensin II
Manhiani, M. M., Seth, D. M., Banes‐Berceli, A. K. L., Satou, R., Navar, L. G., & Brands, M. W. (2015) · Physiological Reports · doi:10.14814/phy2.12595 · Cited by 17
Nitric oxide generation by the organic nitrate NDBP attenuates oxidative stress and angiotensin II‐mediated hypertension
Porpino, S. K. P., Zollbrecht, C., Peleli, M., Montenegro, M. F., Brandão, M. C. R., de Athayde-Filho, P. F., França-Silva, M. S., Larsson, E., Lundberg, J. O., Weitzberg, E., et al. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13511 · Cited by 16
Comparison of the effects of insulin and SGLT2 inhibitor on the Renal Renin-Angiotensin system in type 1 diabetes mice
Miyata, K. N., Zhao, S., Wu, C., Lo, C., Ghosh, A., Chénier, I., Filep, J. G., Ingelfinger, J. R., Zhang, S., & Chan, J. S. D. (2020) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2020.108107 · Cited by 16
Superoxide and its interaction with nitric oxide modulates renal function in prehypertensive Ren-2 transgenic rats
Kopkan, L., Husková, Z., Vaňourková, Z., Thumová, M., Škaroupková, P., Červenka, L., & Majid, D. S. A. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e3282efb195 · Cited by 16
Role of NADPH Oxidase in Hypertension and Diabetic Nephropathy
Onozato, M. L., & Tojo, A. (2005) · Current Hypertension Reviews · doi:10.2174/1573402052952825 · Cited by 16
Resurrecting Hope for Antioxidant Treatment of Cardiovascular Disease
O'Connor, P. M., & Gutterman, D. D. (2010) · Circulation Research · doi:10.1161/circresaha.110.223321 · Cited by 16
Revisiting sex as a biological variable in hypertension research
Ryan, M. J., Clemmer, J. S., Mathew, R. O., Faulkner, J., Taylor, E. B., Abais‐Battad, J. M., Hollis, F., & Sullivan, J. C. (2024) · Journal of Clinical Investigation · doi:10.1172/jci180078 · Cited by 16
Utilizing proteomics to understand and define hypertension: where are we and where do we go?
Delles, C., Carrick, E., Graham, D., & Nicklin, S. A. (2018) · Expert Review of Proteomics · doi:10.1080/14789450.2018.1493927 · Cited by 15
Viral transduction of renin rapidly establishes persistent hypertension in diverse murine strains
Harlan, S. M., Ostroski, R., Coşkun, T., Yantis, L. D., Breyer, M. D., & Heuer, J. G. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00106.2015 · Cited by 16
Simultaneous determination of renal plasma flow and glomerular filtration rate in conscious mice using dual bolus injection
Sällström, J., & Fridén, M. (2013) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2013.01.010 · Cited by 15
Renal vasoconstriction by vasopressin V1areceptors is modulated by nitric oxide, prostanoids, and superoxide but not the ADP ribosyl cyclase CD38
Moss, N., Kopple, T. E., & Arendshorst, W. J. (2014) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00664.2013 · Cited by 15
Synergistic actions of enalapril and tempol during chronic angiotensin II-induced hypertension
Elmarakby, A. A., Williams, J. M., Imig, J. D., Pollock, J. S., & Pollock, D. M. (2006) · Vascular Pharmacology · doi:10.1016/j.vph.2006.09.004 · Cited by 14
Increased Angiotensin II–Induced Hypertension and Inflammatory Cytokines in Mice Lacking Angiotensin-Converting Enzyme N Domain Activity
Ong, F. S.-C., Lin, C. X., Campbell, D. J., Okwan-Duodu, D. K., Chen, X., Blackwell, W.-L. B., Shah, K. H., González-Villalobos, R. A., Shen, X. Z., Fuchs, S., et al. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.180844 · Cited by 13
Redox Signaling in an In Vivo Murine Model of Low Magnitude Oscillatory Wall Shear Stress
Willett, N. J., Kundu, K., Knight, S. F., Dikalov, S., Murthy, N., & Taylor, W. R. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3550 · Cited by 13
Iohexol plasma clearance, a simple and reliable method to measure renal function in conscious mice
Lima, S. L., Rodríguez‐Rodríguez, A. E., Martín-Higueras, C., Sierra‐Ramos, C., Carrara, F., Arnau, M. R., de la Rosa, D. Á., SALIDO, E. C., Gaspari, F., & Porrini, E. (2016) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-016-1843-4 · Cited by 13
Increased Susceptibility of Mice Lacking Renin-b to Angiotensin II–Induced Organ Damage
Nakagawa, P., Nair, A. R., Agbor, L. N., Gomez, J. A., Wu, J. F., Zhang, S. Y., Lu, K., Morgan, D. A., Rahmouni, K., Grobe, J. L., et al. (2020) · Hypertension · doi:10.1161/hypertensionaha.120.14972 · Cited by 13
Pathophysiology of Primary Hypertension
Carey, R. M. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-374530-9.00020-6 · Cited by 13
Alterations in the subcellular distribution of NADPH oxidase p47phoxin hypothalamic paraventricular neurons following slow‐pressor angiotensin II hypertension in female mice with accelerated ovarian failure
Kempen, T. A. V., Narayan, A., Waters, E. M., Marques-Lopes, J., Iadecola, C., Glass, M. J., Pickel, V. M., & Milner, T. A. (2015) · The Journal of Comparative Neurology · doi:10.1002/cne.23944 · Cited by 13
Increased salt sensitivity induced by sensory denervation: role of superoxide.
Song, W., Chen, A. F., & Wang, D. H. (2004) · PubMed · Cited by 13
Differential Effects of Myocardial Afadin on Pressure Overload-Induced Compensated Cardiac Hypertrophy
Zankov, D. P., Sato, A., Shimizu, A., & Ogita, H. (2017) · Circulation Journal · doi:10.1253/circj.cj-17-0394 · Cited by 12
Vascular Smooth Muscle-Specific EP4 Receptor Deletion in Mice Exacerbates Angiotensin II-Induced Renal Injury
Thibodeau, J.-F., Holterman, C. E., He, Y., Carter, A., Cron, G. O., Boisvert, N. C., Abd‐Elrahman, K. S., Hsu, K., Ferguson, S. S. G., & Kennedy, C. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6592 · Cited by 12
Dissecting the Causes of Oxidative Stress in an In Vivo Model of Hypertension
Tain, Y., & Baylis, C. (2006) · Hypertension · doi:10.1161/01.hyp.0000242927.24428.25 · Cited by 12
Hypertension-induced neurovascular and cognitive dysfunction at single-cell resolution
Schaeffer, S. M., Pacholko, A. G., Santisteban, M. M., Ahn, S. J., Racchumi, G., Wang, G., Park, L., Faraco, G., Anrather, J., & Iadecola, C. (2025) · Neuron · doi:10.1016/j.neuron.2025.10.018 · Cited by 14
A new mechanism for the sex differences in angiotensin II-induced hypertension: the role of macula densa NOS1β-mediated tubuloglomerular feedback
Zhang, J., Qu, L., Wei, J., Jiang, S., Xu, L., Wang, L., Cheng, F., Jiang, K., Buggs, J., & Liu, R. (2020) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00312.2020 · Cited by 10
Hemodynamic Effects of the Nitric Oxide Donor DETA/NO in Mice
Schyvens, C. G., Cowden, W. B., Zhang, Y., McKenzie, K. U. S., & Whitworth, J. A. (2004) · Clinical and Experimental Hypertension · doi:10.1081/ceh-200031828 · Cited by 10
PKN2 deficiency leads both to prenatal ‘congenital’ cardiomyopathy and defective angiotensin II stress responses
Marshall, J. J. T., Cull, J. J., Alharbi, H. O., Thin, M. Z., Cooper, S. T. E., Barrington, C., Vanyai, H. K., Snoeks, T. J. A., Siow, B. M., Suárez‐Bonnet, A., et al. (2022) · Biochemical Journal · doi:10.1042/bcj20220281 · Cited by 9
Overexpression of NOX2 Exacerbates AngII-Mediated Cardiac Dysfunction and Metabolic Remodelling
Hansen, S. S., Pedersen, T. M., Marin, J., Boardman, N. T., Shah, A. M., Aasum, E., & Hafstad, A. D. (2022) · Antioxidants · doi:10.3390/antiox11010143 · Cited by 10
Pathophysiology of Primary Hypertension
Carey, R. M. (2008) · Comprehensive physiology · doi:10.1002/cphy.cp020418 · Cited by 9
Editing of the myosin phosphatase regulatory subunit suppresses angiotensin II induced hypertension via sensitization to nitric oxide mediated vasodilation
Htet, M., Ursitti, J. A., Chen, L., & Fisher, S. A. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02488-w · Cited by 7
Reactivity of renal and mesenteric resistance vessels to angiotensin II is mediated by NOXA1/NOX1 and superoxide signaling
Stevenson, M. D., Vendrov, A. E., Yang, X., Chen, Y., Navarro, H. A., Moss, N., Runge, M. S., Arendshorst, W. J., & Madamanchi, N. R. (2023) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00236.2022 · Cited by 8
PPAR-α knockout leads to elevated blood pressure response to angiotensin II infusion associated with an increase in renal α-1 Na+/K+ ATPase protein expression and activity
Khundmiri, S. J., ECELBARGER, C. A., Amponsem, J., Ji, H., Sandberg, K. L., & Lee, D. L. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120444 · Cited by 6
The Clinical View of Sepsis-Associated AKI: How Basic Science Can Help Solve This Problem
Odum, J. D., Hasson, D. C., Stanski, N. L., Gómez, H., & Soranno, D. E. (2025) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2025.151665 · Cited by 5
Dose-dependent regulation of kidney mitochondrial function by angiotensin II
Sivertsson, E., Ramilo, A. B., Schiffer, T. A., Hansell, P., Friederich‐Persson, M., Persson, P., & Palm, F. (2023) · Upsala Journal of Medical Sciences · doi:10.48101/ujms.v128.10312 · Cited by 5
Antihypertensive Potential of Pistacia lentiscus var. Chia: Molecular Insights and Therapeutic Implications
Efentakis, P., Symeonidi, L., Gianniou, D. D., Mikropoulou, E. V., Giardoglou, P., Valakos, D., Vatsellas, G., Tsota, M., Kostomitsopoulos, N. G., Smyrnioudis, I., et al. (2024) · Nutrients · doi:10.3390/nu16132152 · Cited by 5
Thiol Antioxidants Regulate Angiotensin II AT1 and Arginine Vasopressin V1 Receptor Functions Differently in Vascular Smooth Muscle Cells
Ullian, M. E., Beck, C., Walker, L. P., Fitzgibbon, W. R., & Morinelli, T. A. (2008) · American Journal of Hypertension · doi:10.1038/ajh.2008.323 · Cited by 5
Renal Extraction of Angiotensin II
Jackson, E. K., & Herzer, W. A. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.055236 · Cited by 5
Psychological trauma increases blood pressure sensitivity to angiotensin II via T-lymphocytes independent of psychopathology
Case, A. J., Natour, T., Pitts, L. J., Lauten, T. H., Reed, E. C., Moshfegh, C. M., & Elkhatib, S. K. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1691047 · Cited by 4
Activation of Nrf2 in Mice Causes Early Microvascular Cyclooxygenase-Dependent Oxidative Stress and Enhanced Contractility
Wang, D., Wang, C., Hao, X., Carter, G., Carter, R., Welch, W. J., & Wilcox, C. S. (2022) · Antioxidants · doi:10.3390/antiox11050845 · Cited by 3
Self-citation
Molecular Pathways in Hypertensive Renal Damage
Imig, J. D., Khan, A. H., & El‐Meanawy, A. (2018) · Updates in hypertension and cardiovascular protection · doi:10.1007/978-3-319-59918-2_26 · Cited by 2
Modulation de la biodisponibilité du monoxyde d'azote (no) en physiopathologie vasculaire : intérêt des stocks mobilisables de no et des antioxydants naturels
Sarr, M. (2004) · OpenGrey (Institut de l'Information Scientifique et Technique) · Cited by 2
Mechanisms of vascular disease
Li, Y., Faraci, F. M., Heistad, D. D., Lamping, K. G., Rahmouni, K., & Sigmund, C. D. (2014) · doi:10.17077/etd.7otf4nv9 · Cited by 2
Cardiac hemorrhage precedes hypertension-induced fibrosis in plasminogen activator inhibitor-1 deficient mice
Pettey, A. C., Ito, S., Franklin, M., Howatt, D. A., Moorleghen, J. J., Levitan, B. M., Graf, D. B., Guzmán, V. Z., Zhang, N., Lawrence, D. A., et al. (2026) · Cardiovascular Research · doi:10.1093/cvr/cvag260 · Cited by 1
Sex differences in animal models of complex disorders: Affective disorders, type 2 diabetes mellitus and essential hypertension
Abu-Moch, M., Azab, A. N., Yousef, M., & Agam, G. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119356 · Cited by 1
Role of Glomerular Pressure in Progression
Adamczak, M., & Ritz, E. (2008) · Elsevier eBooks · doi:10.1016/b978-012088488-9.50091-7 · Cited by 1
CALL FOR PAPERS Cardiovascular-Renal Mechanisms in Health and Disease
Welch, W. J., Patel, K., Modlinger, P., Mendonca, M., Kawada, N., Dennehy, K., Aslam, S., Wilcox, C. S., Welch, W. J., Patel, K. B., et al. (2007)
Self-citation
EFEITO DA ESPIRONOLACTONA SOBRE A FUNÇÃO E MORFOLOGIA RENAL DE RATOS HIPERTENSOS POR INFUSÃO CRÔNICA DE ANGIOTENSINA II
Paulo, S. (2012)
Role of Glomerular Mechanical Stress in the Pathogenesis of Chronic Kidney Disease
Fujihara, C. K., & Zatz, R. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-381462-3.00086-0
Hydrogen Sulfide for the Treatment of Hypertensive Nephropathy and Calcium-Based Nephrolithiasis
Dugbartey, G. J. (2023) · Springer eBooks · doi:10.1007/978-3-031-44041-0_5
A newly developed model of atherosclerosis caused by the stress of metabolic syndrome in apolipoprotein E knockout mousePreprint
Tsudome, R., Suematsu, Y., Tashiro, K., Morita, H., Ideishi, A., & Miura, S. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.24.645136
Pathophysiology of Primary Hypertension
Carey, R. M. (1984) · Comprehensive physiology · doi:10.1002/j.2040-4603.1984.tb01027.x
A Protocol for Constructing a Mouse Model of Hypertensive Myocardial Fibrosis Using Angiotensin II
Wu, J., Jiang, H., Lan, X., Hu, H., Chen, M., Li, Y., Luo, G., Liu, Q., & Liu, M. (2025) · Journal of Visualized Experiments · doi:10.3791/69409
Novel Directions In Therapy Against Age-Related Vascular Disease
Wu, H. (2014) · EUR Research Repository (Erasmus University Rotterdam)
Superoxide Dismutases as Redox Regulators and Therapeutic Targets in Vascular and Neurodegenerative Disease
Fukai, T., Varadarajan, S., & Ushio‐Fukai, M. (2026) · Springer eBooks · doi:10.1007/978-3-032-21135-4_6

Authors: Kawada, N., Imai, E., Karber, A., Welch, W. J., & Wilcox, C. S.
Affiliations: Georgetown University (US)
The University of Osaka (JP)
Corresponding author: Kawada, Noritaka
Welch, William J.
Wilcox, Christopher S.
ORCID: Imai, Enyu
Welch, William J.
Wilcox, Christopher S.
Venue: Journal of the American Society of Nephrology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2002-12
Volume: 13
Issue: 12
Pages: 2860-2868
ISSN: 1046-6673 (ISSN-L)
DOI: 10.1097/01.asn.0000035087.11758.ed
OpenAlex: W2127905773
Cited by: 195
References: 47
Citations by year: 2026: 3 · 2025: 6 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 7 · 2019: 4 · 2018: 8 · 2017: 7 · 2016: 11 · 2015: 8 · 2014: 8 · 2013: 7 · 2012: 9
FWCI: 7.46
Type: journal article
Language: en
Open access: closed
Locations: Journal of the American Society of Nephrology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (HL‐68686, P01HL068686)
National Institute of Diabetes and Digestive and Kidney Diseases (DK‐49870, DK 36079, R01DK049870)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords: angiotensin II, oxidative stress, blood pressure, renal function, glomerular filtration rate, filtration fraction, renal vascular resistance, renal excretion, rats, infusion rate, renal hemodynamics, nitric oxide synthase inhibition, angiotensin II receptor, renin-angiotensin system
MeSH terms: Angiotensin II, Animals, Antioxidants, Blood Pressure, Cyclic N-Oxides, Dose-Response Relationship, Drug, Drug Administration Schedule, Drug Combinations, Infusion Pumps, Kidney, Male, Mice, Inbred C57BL, Spin Labels, Systole, Vasoconstrictor Agents, Dinoprost, Oxidative Stress, F2-Isoprostanes, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A Mouse Model of Angiotensin II Slow Pressor Response: Role of Oxidative Stress

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks