The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Insulin Resistance and Risk of Chronic Kidney Disease in Nondiabetic US Adults
Abstract
This study examined the relationship of fasting serum glucose, insulin, C-peptide, glycosylated hemoglobin A (HbA1c), and Homeostasis Model Assessment (HOMA)-insulin resistance to risk of chronic kidney disease (CKD) among 6453 persons without diabetes (fasting glucose <126 mg/dl and not taking diabetes medication) who participated in the Third National Health and Nutrition Examination Survey and were aged 20 yr or older. CKD was defined as an estimated GFR <60 ml/min per 1.73 m(2). The prevalence of CKD was significantly and progressively higher with increasing levels of serum insulin, C-peptide, HbA1c, and HOMA-insulin resistance. After adjustment for potential confounding variables, the odds ratio of CKD for the highest compared with the lowest quartile was 4.03 (95% confidence interval [CI], 1.81 to 8.95; P = 0.001), 11.4 (95% CI, 4.07 to 32.1; P < 0.001), 2.67 (95% CI, 1.31 to 5.46; P = 0.002), and 2.65 (95% CI, 1.25 to 5.62; P = 0.008) for serum insulin, C-peptide, HbA1c levels, and HOMA-insulin resistance, respectively. For a one SD higher level of serum insulin (7.14 micro U/ml), C-peptide (0.45 Deltamol/ml), HbA1c (0.52%), and HOMA-insulin resistance (1.93), the odds ratio (95% CI) of CKD was 1.35 (1.16 to 1.57), 2.78 (2.25 to 3.42), 1.69 (1.28 to 2.23), and 1.30 (1.13 to 1.50), respectively. These findings combined with knowledge from previous studies suggest that the insulin resistance and concomitant hyperinsulinemia are presented in CKD patients without clinical diabetes. Further studies into the causality between insulin resistance and CKD are warranted.
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Blood Pressure and End-Stage Renal Disease in Men
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Self-citationInsulin resistance and cardiovascular disease
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Cited by
Metabolic Syndrome and the Risk for Chronic Kidney Disease among Nondiabetic Adults
Kurella, M., Lo, J. C., & Chertow, G. M. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005010106 · Cited by 709
Obesity and Obesity-Initiated Metabolic Syndrome: Mechanistic Links to Chronic Kidney Disease
Wahba, I. M., & Mak, R. H. (2007) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.04071206 · Cited by 513
Obesity and Prevalent and Incident CKD: The Hypertension Detection and Follow-Up Program
Kramer, H., Luke, A., Bidani, A., Cao, G., Cooper, R., & McGee, D. (2005) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2005.06.007 · Cited by 414
The CardioMetabolic Health Alliance
Sperling, L. S., Mechanick, J. I., Neeland, I. J., Herrick, C. J., Després, J.-P., Ndumele, C. E., Vijayaraghavan, K., Handelsman, Y., Puckrein, G. A., Araneta, M. R. G., et al. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.06.1328 · Cited by 294
Insulin Resistance, Hyperinsulinemia, and Renal Injury: Mechanisms and Implications
Sarafidis, P. A., & Ruilope, L. M. (2006) · American Journal of Nephrology · doi:10.1159/000093632 · Cited by 272
Metadata
- Authors
- Chen, J., Muntner, P., Hamm, L. L., Fonseca, V., Batuman, V., Whelton, P. K., & He, J.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2003-02
- Volume
- 14
- Issue
- 2
- Pages
- 469-477
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2154975997
- Cited by
- 396
- References
- 32
- FWCI
- 11.08
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chen, J., Muntner, P., Hamm, L. L., Fonseca, V., Batuman, V., Whelton, P. K., & He, J. (2003). Insulin Resistance and Risk of Chronic Kidney Disease in Nondiabetic US Adults. Journal of the American Society of Nephrology. https://doi.org/10.1097/01.asn.0000046029.53933.09
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