The DOI matches its Crossref record; 123 of the 123 references it cites were found in a registry or an index.
Insulin Resistance, Hyperinsulinemia, and Renal Injury: Mechanisms and Implications
Abstract
Most of the basic components of the metabolic syndrome, namely type 2 diabetes mellitus, hypertension, obesity, or low high-density lipoprotein cholesterol levels, apart from being major risk factors for cardiovascular disease have been also associated with an increased risk of chronic kidney disease. However, several epidemiologic studies conducted over the past years suggest that the central component of the syndrome, insulin resistance, as well as compensatory hyperinsulinemia are independently associated with an increased prevalence of chronic kidney disease. In addition, background studies support the existence of several pathways linking insulin resistance and hyperinsulinemia with kidney damage. Insulin per se promotes the proliferation of renal cells and stimulates the production of other important growth factors such as insulin-like growth factor-1 and transforming growth factor beta. Insulin also upregulates the expression of angiotensin II type 1 receptor in mesangial cells, thus enhancing the deleterious effects of angiotensin II in the kidney, and stimulates production and renal action of endothelin-1. Moreover, insulin resistance and hyperinsulinemia are associated with decreased endothelial production of nitric oxide and increased oxidative stress which have been also implicated in the progression of diabetic nephropathy. This review analyzes the above and other potential mechanisms, through which insulin resistance and hyperinsulinemia can contribute to renal injury.
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Citations
Cites
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ResultMolecular and Cellular Aspects of the Insulin-Like Growth Factor I Receptor
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Cited by
Obesity and chronic kidney disease
Jiang, Z., Wang, Y., Zhao, X., Cui, H., Han, M., Ren, X., Gang, X., & Wang, G. (2023) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00179.2022 · Cited by 267
Impact of treating the metabolic syndrome on chronic kidney disease
Agrawal, V., Shah, A., Rice, C., Franklin, B. A., & McCullough, P. A. (2009) · Nature Reviews Nephrology · doi:10.1038/nrneph.2009.114 · Cited by 62
Perlstein, T. S., Gerhard-Herman, M., Hollenberg, N. K., Williams, G. H., & Thomas, A. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006091026 · Cited by 39
Metadata
- Authors
- Sarafidis, P. A., & Ruilope, L. M.
- Venue
- American Journal of Nephrology
- Publisher
- S. Karger AG
- Published
- 2006
- Volume
- 26
- Issue
- 3
- Pages
- 232-244
- ISSN
- 0250-8095 (ISSN-L)
- 1421-9670
- OpenAlex
- W1986440652
- Cited by
- 272
- References
- 123
- FWCI
- 12.81
- Type
- journal article
- Language
- en
- Open access
- closed
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