The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Acute Renal Failure in Patients with Sepsis in a Surgical ICU: Predictive Factors, Incidence, Comorbidity, and Outcome
Abstract
Acute renal failure (ARF) is a common complication in intensive care unit (ICU) patients. Although there are several reports on outcome of septic patients with ARF, there are no data regarding predisposing factors for ARF. Therefore, the incidence of ARF was investigated in 185 sepsis patients admitted in a surgical ICU during a 16-mo period. Variables predisposing to ARF on day 1 of sepsis were evaluated with univariate and multivariable analyses. APACHE II and SOFA scores were compared during a 14-d period. Additionally, the impact of organ failure on mortality was evaluated. ARF developed in 16.2% of the patients, and 70.0% of these needed renal replacement therapy (RRT). Patients with ARF were more severely ill and had a higher mortality. Remarkably, serum creatinine was already increased on day 1. Creatinine > 1 mg/dl and pH < 7.30, both on day 1 of sepsis, were independently associated with ARF. Age, need for vasoactive therapy, mechanical ventilation, and RRT, but not ARF itself, were associated with mortality. In conclusion, ARF was a frequent complication in sepsis. Sepsis patients with ARF were more severely ill and had a higher mortality. Need for RRT was independently associated with mortality. A simple risk model for ARF, on basis of two readily available parameters on day 1 of sepsis, was developed. This model allows initiating specific therapeutic measures earlier in the course of sepsis, hopefully resulting in a lower incidence of ARF and needi for RRT, thereby lowering mortality.
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Cites
APACHE II-A Severity of Disease Classification System: Reply
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Early goal-directed therapy in the treatment of severe sepsis and septic shock
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Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis
Bernard, G. R., Vincent, J.-L., Laterre, P.-F., LaRosa, S. P., Dhainaut, J.-F., Lopez-Rodriguez, A., Steingrub, J. S., Garber, G. E., Helterbrand, J. D., Ely, E. W., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103083441001 · Cited by 6,132
Hospital-acquired renal insufficiency
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Elevation of Systemic Oxygen Delivery in the Treatment of Critically Ill Patients
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Cited by
Global epidemiology and outcomes of acute kidney injury
Hoste, E. A. J., Kellum, J. A., Selby, N. M., Zarbock, A., Palevsky, P. M., Bagshaw, S. M., Goldstein, S. L., Cerdá, J., & Chawla, L. S. (2018) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0052-0 · Cited by 1,486
Self-citationCoca, S. G., Yusuf, B., Shlipak, M. G., Garg, A. X., & Parikh, C. R. (2009) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2008.11.034 · Cited by 1,161
Incidence and Mortality of Acute Renal Failure in Medicare Beneficiaries, 1992 to 2001
Xue, J. L., Daniels, F., Star, R. A., Kimmel, P. L., Eggers, P. W., Molitoris, B. A., Himmelfarb, J., & Collins, A. J. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005060668 · Cited by 765
Biomarkers for the diagnosis and risk stratification of acute kidney injury: A systematic review
Coca, S. G., Yalavarthy, R., Concato, J., & Parikh, C. R. (2008) · Kidney International · doi:10.1038/sj.ki.5002729 · Cited by 685
Early acute kidney injury and sepsis: a multicentre evaluation
Bagshaw, S. M., George, C., Bellomo, R., & the ANZICS Database Management Committee (2008) · Critical Care · doi:10.1186/cc6863 · Cited by 685
Metadata
- Authors
- Hoste, E. A. J., Lameire, N. H., Vanholder, R. C., Benoit, D. D., Decruyenaere, J. M. A., & Colardyn, F. A.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2003-04
- Volume
- 14
- Issue
- 4
- Pages
- 1022-1030
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2150098992
- Cited by
- 406
- References
- 36
- FWCI
- 12.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Acute Renal Failure in Patients with Sepsis in a Surgical ICU: Predictive Factors, Incidence, Comorbidity, and Outcome. https://app.cochat.ai/papers/10.1097/01.asn.0000059863.48590.e9
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- Hoste, E. A. J., Lameire, N. H., Vanholder, R. C., Benoit, D. D., Decruyenaere, J. M. A., & Colardyn, F. A. (2003). Acute Renal Failure in Patients with Sepsis in a Surgical ICU: Predictive Factors, Incidence, Comorbidity, and Outcome. Journal of the American Society of Nephrology. https://doi.org/10.1097/01.asn.0000059863.48590.e9
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
