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Effects of Oxandrolone on Outcome Measures in the Severely Burned: A Multicenter Prospective Randomized Double-Blind Trial
Abstract
Severe burns induce pathophysiologic problems, among them catabolism of lean mass, leading to protracted hospitalization and prolonged recovery. Oxandrolone is an anabolic agent shown to decrease lean mass catabolism and improve wound healing in the severely burned patients. We enrolled 81 adult subjects with burns 20% to 60% TBSA in a multicenter trial testing the effects of oxandrolone on length of hospital stay. Subjects were randomized between oxandrolone 10 mg every 12 hours or placebo. The study was stopped halfway through projected enrollment because of a significant difference between groups found on planned interim analysis. We found that length of stay was shorter in the oxandrolone group (31.6 +/- 3.1 days) than placebo (43.3 +/- 5.3 days; P < .05). This difference strengthened when deaths were excluded and hospital stay was indexed to burn size (1.24 +/- 0.15 days/% TBSA burned vs 0.87 +/- 0.05 days/% TBSA burned, P < .05). We conclude that treatment using oxandrolone should be considered for use in the severely burned while hepatic transaminases are monitored.
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Cited by
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The immune system’s role in sepsis progression, resolution, and long-term outcome
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Friedrich, O., Reid, M. B., Van den Berghe, G., Vanhorebeek, I., Hermans, G., Rich, M. M., & Larsson, L. (2015) · Physiological Reviews · doi:10.1152/physrev.00028.2014 · Cited by 396
ESPEN endorsed recommendations: Nutritional therapy in major burns
Rousseau, A.-F., Losser, M.-R., Ichai, C., & Berger, M. M. (2013) · Clinical Nutrition · doi:10.1016/j.clnu.2013.02.012 · Cited by 388
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Metadata
- Authors
- Wolf, S. E., Edelman, L. S., Kemalyan, N., Donison, L., Cross, J., Underwood, M., Spence, R. J., Noppenberger, D., Palmieri, T. L., Greenhalgh, D. G., Lawless, M., Voigt, D., Edwards, P., Warner, P., Kagan, R., Hatfield, S., Jeng, J., Crean, D., Hunt, J., Purdue, G., Burris, A., Cairns, B., Kessler, M., Klein, R. L., Baker, R., Yowler, C., Tutulo, W., Foster, K., Caruso, D., Hildebrand, B., Benjamin, W., Villarreal, C., Sanford, A. P., & Saffle, J.
- Venue
- Journal of Burn Care & Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-03
- Volume
- 27
- Issue
- 2
- Pages
- 131-139
- ISSN
- 1559-047X (ISSN-L)
- OpenAlex
- W2036853917
- Cited by
- 182
- References
- 0
- FWCI
- 9.08
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Effects of Oxandrolone on Outcome Measures in the Severely Burned: A Multicenter Prospective Randomized Double-Blind Trial. https://app.cochat.ai/papers/10.1097/01.bcr.0000202620.55751.4f
- The paper
- Wolf, S. E., Edelman, L. S., Kemalyan, N., Donison, L., Cross, J., Underwood, M., Spence, R. J., Noppenberger, D., Palmieri, T. L., Greenhalgh, D. G., Lawless, M., Voigt, D., Edwards, P., Warner, P., Kagan, R., Hatfield, S., Jeng, J., Crean, D., Hunt, J., . . . Saffle, J. (2006). Effects of Oxandrolone on Outcome Measures in the Severely Burned: A Multicenter Prospective Randomized Double-Blind Trial. Journal of Burn Care & Research. https://doi.org/10.1097/01.bcr.0000202620.55751.4f
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
