The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
The Regulation of Chondrocyte Function by Proinflammatory Mediators: Prostaglandins and Nitric Oxide
Abstract
Within the mature articular cartilage matrix, which has no blood or nerve supply, chondrocytes show little metabolic activity with low turnover of matrix components. Under conditions of stress because of biomechanical factors, however, chondrocytes are capable of producing mediators that are associated with inflammation, including cytokines such as interleukin-1 and tumor necrosis factor-alpha, which in turn stimulate the production of prostaglandins and nitric oxide. Chondrocytes also express receptors for these mediators, which accumulate at high local concentrations and can act in an autocrine-paracrine fashion to feedback-regulate chondrocyte responses. Prostaglandin E2 can exert catabolic or anabolic effects depending on the microenvironment. Nitric oxide can promote cellular injury and increase chondrocyte susceptibility to cytokine-induced apoptosis. Because cross-talk between these mediators produces complex modulation of catabolic and anabolic pathways, further studies in vitro and in vivo are required to elucidate their precise roles in osteoarthritis.
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“mPGES-1 is inducible by LPS and inflammatory cytokines.(65,92,136) The coordinate regulation and functional coupling of mPGES-1 and COX-2 have been reported.”
BackgroundNitric oxide and inflammatory mediators in the perpetuation of osteoarthritis
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Cited by
Osteoarthritis: an update with relevance for clinical practice
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Self-citationApoptosis signaling pathways in osteoarthritis and possible protective role of melatonin
Hosseinzadeh, A., Kamrava, S. K., Joghataei, M. T., Darabi, R., Shakeri‐Zadeh, A., Shahriari, M., Reiter, R. J., Ghaznavi, H., & Mehrzadi, S. (2016) · Journal of Pineal Research · doi:10.1111/jpi.12362 · Cited by 344
Metadata
- Authors
- Goldring, M. B., & Berenbaum, F.
- Venue
- Clinical Orthopaedics & Related Research
- Published
- 2004-10
- Volume
- 427
- Issue
- 427 Suppl
- Pages
- S37-S46
- ISSN
- 0009-921X (ISSN-L)
- OpenAlex
- W2081050068
- Cited by
- 245
- References
- 8
- FWCI
- 6.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- Goldring, M. B., & Berenbaum, F. (2004). The Regulation of Chondrocyte Function by Proinflammatory Mediators: Prostaglandins and Nitric Oxide. Clinical Orthopaedics & Related Research. https://doi.org/10.1097/01.blo.0000144484.69656.e4
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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