Molecular Identification of Cytosolic Prostaglandin E2 Synthase That Is Functionally Coupled with Cyclooxygenase-1 in Immediate Prostaglandin E2Biosynthesis
Open accessAbstract
Here we report the molecular identification of cytosolic glutathione (GSH)-dependent prostaglandin (PG) E(2) synthase (cPGES), a terminal enzyme of the cyclooxygenase (COX)-1-mediated PGE(2) biosynthetic pathway. GSH-dependent PGES activity in the cytosol of rat brains, but not of other tissues, increased 3-fold after lipopolysaccharide (LPS) challenge. Peptide microsequencing of purified enzyme revealed that it was identical to p23, which is reportedly the weakly bound component of the steroid hormone receptor/hsp90 complex. Recombinant p23 expressed in Escherichia coli and 293 cells exhibited all the features of PGES activity detected in rat brain cytosol. A tyrosine residue near the N terminus (Tyr(9)), which is known to be critical for the activity of cytosolic GSH S-transferases, was essential for PGES activity. The expression of cPGES/p23 was constitutive and was unaltered by proinflammatory stimuli in various cells and tissues, except that it was increased significantly in rat brain after LPS treatment. cPGES/p23 was functionally linked with COX-1 in marked preference to COX-2 to produce PGE(2) from exogenous and endogenous arachidonic acid, the latter being supplied by cytosolic phospholipase A(2) in the immediate response. Thus, functional coupling between COX-1 and cPGES/p23 may contribute to production of the PGE(2) that plays a role in maintenance of tissue homeostasis.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
PTGES3 is reported to be a cytosolic prostaglandin synthase that converts PGH2 to PGE2.
“PTGES3 is also reported to be a cytosolic prostaglandin synthase that converts Prostaglandin H2 (PGH2) to Prostaglandin E2 (PGE2)47”
From Genome-scale CRISPR screens identify PTGES3 as a direct modulator of androgen receptor function in advanced prostate cancer (2025) · cites this paper as [47]
PTGES3 protein is reported to have several protein functions and to be localized to both the cytosol and nucleus.
“PTGES3 protein is reported to have several protein functions and to be localized to both the cytosol and nucleus41–49 (Fig. 3f).”
From Genome-scale CRISPR screens identify PTGES3 as a direct modulator of androgen receptor function in advanced prostate cancer (2025) · cites this paper as [47]
The proposed PGE2 enzymatic site is at the N terminus of PTGES3 whereas the proposed HSP90 interaction motif is at the C terminus.
“The proposed PGE2 enzymatic site is at the N terminus of the protein whereas the proposed HSP90 interaction motif is at the C terminus of the protein41,47.”
From Genome-scale CRISPR screens identify PTGES3 as a direct modulator of androgen receptor function in advanced prostate cancer (2025) · cites this paper as [47]
Cites
Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2
Smith, W. L., Garavito, R. M., & DeWitt, D. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.52.33157 · Cited by 1,973 · see citing works
Jakobsson, P., Thorén, S., Morgenstern, R., & Samuelsson, B. O. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7220 · Cited by 995 · see citing works
Murakami, M., Naraba, H., Tanioka, T., Semmyo, N., Nakatani, Y., Kojima, F., Ikeda, T., Fueki, M., Ueno, A., Oh-ishi, S., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003505200 · Cited by 964 · see citing works
Self-citationRequirement of a 5-lipoxygenase-activating protein for leukotriene synthesis
Dixon, R. A. F., Diehl, R. E., Opas, E. E., Rands, E., Vickers, P. J., Evans, J. F., Gillard, J. W., & Miller, D. K. (1990) · Nature · doi:10.1038/343282a0 · Cited by 772 · see citing works
Different Intracellular Locations for Prostaglandin Endoperoxide H Synthase-1 and −2
Morita, I., Schindler, M., Regier, M. K., Otto, J. C., Hori, T., DeWitt, D. L., & Smith, W. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.18.10902 · Cited by 572 · see citing works
Glutathione S-Transferases - A Review
Salinas, A. E., & Wong, M. G. (1999) · Current Medicinal Chemistry · doi:10.2174/0929867306666220208213032 · Cited by 557 · see citing works
Functional requirement of p23 and Hsp90 in telomerase complexesPreprint
Holt, S. E., Aisner, D. L., Baur, J. A., Tesmer, V. M., Dy, M., Ouellette, M., Trager, J. B., Morin, G. B., Toft, D. O., Shay, J. W., et al. (1999) · Genes & Development · doi:10.1101/gad.13.7.817 · Cited by 533 · see citing works
The Functions of Five Distinct Mammalian Phospholipase A2s in Regulating Arachidonic Acid Release
Murakami, M., Shimbara, S., Kambe, T., Kuwata, H., Winstead, M. V., Tischfield, J. A., & Kudo, I. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.23.14411 · Cited by 366 · see citing works
Self-citationJakobsson, P., Morgenstern, R., Mancini, J. A., Ford‐Hutchinson, A. W., & Persson, B. (1999) · Protein Science · doi:10.1110/ps.8.3.689 · Cited by 366 · see citing works
Murakami, M., Kambe, T., Shimbara, S., & Kudo, I. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.5.3103 · Cited by 348 · see citing works
Self-citationSpencer, A. G., Woods, J. W., Arakawa, T., Singer, I. I., & Smith, W. L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.16.9886 · Cited by 334 · see citing works
Folding of the Glucocorticoid Receptor by the Heat Shock Protein (hsp) 90-based Chaperone Machinery
Dittmar, K. D., Demady, D. R., Stancato, L. F., Krishna, P., & Pratt, W. B. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.34.21213 · Cited by 265 · see citing works
Cloning and Crystal Structure of Hematopoietic Prostaglandin D Synthase
Kanaoka, Y., Ago, H., Inagaki, E., Nanayama, T., Miyano, M., Kikuno, R. F., Fujii, Y., Eguchi, N., Toh, H., Urade, Y., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80374-8 · Cited by 258 · see citing works
Nucleotides and Two Functional States of hsp90
Sullivan, W., Stensgard, B. A., Caucutt, G., Bartha, B. B., McMahon, N., Alnemri, E. S., Litwack, G., & Toft, D. O. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.12.8007 · Cited by 235 · see citing works
Kulmacz, R. J., & Wang, L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.41.24019 · Cited by 218 · see citing works
Murakami, M., Matsumoto, R., Austen, K. F., & Arm, J. P. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31786-6 · Cited by 217 · see citing works
Self-citationLipocalin-type Prostaglandin D Synthase (β-Trace) Is a Newly Recognized Type of Retinoid Transporter
Tanaka, T., Urade, Y., Kimura, H., Eguchi, N., Nishikawa, A., & Hayaishi, O. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.25.15789 · Cited by 206 · see citing works
Characterization of a Novel 23-Kilodalton Protein of Unactive Progesterone Receptor Complexes
Johnson, J. L., Beito, T. G., Krco, C. J., & Toft, D. O. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.3.1956 · Cited by 197 · see citing works
Kuwata, H., Nakatani, Y., Murakami, M., & Kudo, I. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.3.1733 · Cited by 187 · see citing works
Self-citationNaraba, H., Murakami, M., Matsumoto, H., Shimbara, S., Ueno, A., Kudo, I., & Oh‐ishi, S. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.6.2974 · Cited by 178 · see citing works
Self-citationNagata, A., Suzuki, Y., Igarashi, M., Eguchi, N., Toh, H., Urade, Y., & Hayaishi, O. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.9.4020 · Cited by 175 · see citing works
Freeman, B. C., Felts, S. J., Toft, D. O., & Yamamoto, K. R. (2000) · Genes & Development · doi:10.1101/gad.14.4.422 · Cited by 168 · see citing works
Murakami, M., Kambe, T., Shimbara, S., Yamamoto, S., Kuwata, H., & Kudo, I. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.42.29927 · Cited by 166 · see citing works
Self-citationMurakami, M., Kambe, T., Shimbara, S., Higashino, K.-I., Hanasaki, K., Arita, H., Horiguchi, M., Arita, M., Arai, H., Inoue, K., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.44.31435 · Cited by 157 · see citing works
Self-citationWatanabe, K., Yoshida, R., Shimizu, T., & Hayaishi, O. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)88884-6 · Cited by 149 · see citing works
Crystal Structure and Activity of Human p23, a Heat Shock Protein 90 Co-chaperone
Weaver, A. J., Sullivan, W. P., Felts, S. J., Owen, B. A. L., & Toft, D. O. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003410200 · Cited by 136 · see citing works
Murakami, M., Nakatani, Y., & Kudo, I. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.47.30041 · Cited by 132 · see citing works
Self-citationHutchison, K. A., Stancato, L. F., Owens-Grillo, J. K., Johnson, J. L., Krishna, P., Toft, D. O., & Pratt, W. B. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.32.18841 · Cited by 125 · see citing works
Binding of Biliverdin, Bilirubin, and Thyroid Hormones to Lipocalin-Type Prostaglandin D Synthase
Beuckmann, C. T., Aoyagi, M., Okazaki, I., Hiroike, T., Toh, H., Hayaishi, O., & Urade, Y. (1999) · Biochemistry · doi:10.1021/bi990261p · Cited by 124 · see citing works
Bohen, S. P. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.6.3330 · Cited by 106 · see citing works
Morishima, Y., Kanelakis, K. C., Silverstein, A. M., Dittmar, K. D., Estrada, L., & Pratt, W. B. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.10.6894 · Cited by 106 · see citing works
Fournier, T., Fadok, V. A., & Henson, P. M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.49.31065 · Cited by 103 · see citing works
Purification and characterization of membrane-bound prostaglandin E synthase from bovine heart
Watanabe, K., Kurihara, K., & Suzuki, T. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(99)00084-0 · Cited by 103 · see citing works
Watanabe, K., Kurihara, K., Tokunaga, Y., & Hayaishi, O. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6708 · Cited by 90 · see citing works
Tanaka, Y., Ward, S. L., & Smith, W. L. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)75796-2 · Cited by 89 · see citing works
Nakatani, Y., Tanioka, T., Sunaga, S., Murakami, M., & Kudo, I. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.2.1161 · Cited by 88 · see citing works
Self-citationRole of prostaglandin H synthase-2 in prostaglandin E2 formation in rat carrageenin-induced pleurisy
Harada, Y., Hatanaka, K., Kawamura, M., Saito, M., Ogino, M., Majima, M., Ohno, T., Ogino, K., Yamamoto, K., Taketani, Y., et al. (1996) · Prostaglandins · doi:10.1016/0090-6980(95)00168-9 · Cited by 88 · see citing works
Liou, J., Shyue, S., Tsai, M., Chung, C., Chu, K.-Y., & Wu, K. K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.20.15314 · Cited by 88 · see citing works
Ogorochi, T., Ujihara, M., & Narumiya, S. (1987) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1987.tb05602.x · Cited by 69 · see citing works
cDNA Cloning, Expression, and Mutagenesis Study of Liver-type Prostaglandin F Synthase
Suzuki, T., Fujii, Y., Miyano, M., Chen, L., Takahashi, T., & Watanabe, K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.1.241 · Cited by 68 · see citing works
Pinzar, E., Miyano, M., Kanaoka, Y., Urade, Y., & Hayaishi, O. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000750200 · Cited by 59 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Prostaglandins and Inflammation
Ricciotti, E., & FitzGerald, G. A. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.207449 · Cited by 3,852 · see citing works
Murakami, M., Naraba, H., Tanioka, T., Semmyo, N., Nakatani, Y., Kojima, F., Ikeda, T., Fueki, M., Ueno, A., Oh-ishi, S., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003505200 · Cited by 964 · see citing works
Self-citationPharmacokinetics and pharmacodynamics of systemically administered glucocorticoids.
Czock, D., Keller, F., Rasche, F. M., & H??ussler, U. (2005) · Clinical Pharmacokinetics · doi:10.2165/00003088-200544010-00003 · Cited by 886 · see citing works
Prostaglandin E2 synthesis and secretion: The role of PGE2 synthases
Park, J. Y., Pillinger, M. H., & Abramson, S. B. (2006) · Clinical Immunology · doi:10.1016/j.clim.2006.01.016 · Cited by 793 · see citing works
Why there are two cyclooxygenase isozymes
Smith, W. L., & Langenbach, R. J. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13271 · Cited by 612 · see citing works
Cytokines, Prostaglandins and Parturition—A Review
Keelan, J. A., Blumenstein, M., Helliwell, R. J. A., Sato, T., Marvin, K. W., & Mitchell, M. D. (2003) · Placenta · doi:10.1053/plac.2002.0948 · Cited by 607 · see citing works
Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase
Trebino, C. E., Stock, J. L., Gibbons, C. P., Naiman, B. M., Wachtmann, T. S., Umland, J. P., Pandher, K., Lapointe, J., Saha, S., Roach, M. L., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1332766100 · Cited by 552 · see citing works
Membrane Prostaglandin E Synthase-1: A Novel Therapeutic Target
Samuelsson, B. O., Morgenstern, R., & Jakobsson, P. (2007) · Pharmacological Reviews · doi:10.1124/pr.59.3.1 · Cited by 537 · see citing works
Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology
Buczynski, M. W., Dumlao, D. S., & Dennis, E. A. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r900004-jlr200 · Cited by 531 · see citing works
COX-2 and beyond: approaches to prostaglandin inhibition in human disease
FitzGerald, G. A. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1225 · Cited by 518 · see citing works
Enzymes of the Cyclooxygenase Pathways of Prostanoid Biosynthesis
Smith, W., Urade, Y., & Jakobsson, P. (2011) · Chemical Reviews · doi:10.1021/cr2002992 · Cited by 480 · see citing works
Phillis, J. W., Horrocks, L. A., & Farooqui, A. A. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.02.002 · Cited by 456 · see citing works
Yamagata, K., Matsumura, K., Inoue, W., Shiraki, T., Suzuki, K., Yasuda, S., Sugiura, H., Cao, C., Watanabe, Y., & Kobayashi, S. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02669.2001 · Cited by 372 · see citing works
Recent advances in molecular biology and physiology of the prostaglandin E2-biosynthetic pathway
Murakami, M., & Kudo, I. (2003) · Progress in Lipid Research · doi:10.1016/s0163-7827(03)00037-7 · Cited by 371 · see citing works
Self-citationCyclooxygenases, prostanoids, and tumor progression
Wang, M., Honn, K. V., & Nie, D. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9096-5 · Cited by 344 · see citing works
Murakami, M., Nakashima, K., Kamei, D., Masuda, S., Ishikawa, Y., Ishii, T., Ohmiya, Y., Watanabe, K., & Kudo, I. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305108200 · Cited by 344 · see citing works
Self-citationJackson, S. (2012) · Topics in current chemistry · doi:10.1007/128_2012_356 · Cited by 334 · see citing works
Cyclooxygenase-2 and prostaglandins in articular tissues
Martel‐Pelletier, J., Pelletier, J., & Fahmi, H. (2003) · Seminars in Arthritis and Rheumatism · doi:10.1016/s0049-0172(03)00134-3 · Cited by 334 · see citing works
Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis
Engblom, D., Saha, S., Engström, L., Westman, M., Audoly, L., Jakobsson, P., & Blomqvist, A. G. (2003) · Nature Neuroscience · doi:10.1038/nn1137 · Cited by 310 · see citing works
Uematsu, S., Matsumoto, M., Takeda, K., & Akira, S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.11.5811 · Cited by 308 · see citing works
Identification and Characterization of a Novel Type of Membrane-Associated Prostaglandin E Synthase
Tanikawa, N., Ohmiya, Y., Ohkubo, H., Hashimoto, K., Kangawa, K., Kojima, M., Ito, S., & Watanabe, K. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2002.6531 · Cited by 304 · see citing works
Caughey, G. E., Cleland, L. G., Penglis, P. S., Gamble, J. R., & James, M. J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.5.2831 · Cited by 283 · see citing works
Reduced Pain Hypersensitivity and Inflammation in Mice Lacking Microsomal Prostaglandin E Synthase-1
Kamei, D., Yamakawa, K., Takegoshi, Y., Mikami-Nakanishi, M., Nakatani, Y., Oh‐ishi, S., Yasui, H., Azuma, Y., Hirasawa, N., Ohuchi, K., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400199200 · Cited by 278 · see citing works
Self-citationStichtenoth, D. O., Thorén, S., Bian, H., Peters-Golden, M. L., Jakobsson, P., & Crofford, L. J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.1.469 · Cited by 269 · see citing works
Guay, J., Bateman, K. P., Gordon, R., Mancini, J. A., & Riendeau, D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403106200 · Cited by 267 · see citing works
The Anti-Inflammatory Effects of Prostaglandins
Scher, J. U., & Pillinger, M. H. (2009) · Journal of Investigative Medicine · doi:10.2310/jim.0b013e31819aaa76 · Cited by 259 · see citing works
Mast cells and eicosanoid mediators: a system of reciprocal paracrine and autocrine regulation
Boyce, J. A. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00512.x · Cited by 255 · see citing works
Physiological Regulation of Prostaglandins in the Kidney
Hao, C., & Breyer, M. D. (2007) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100614 · Cited by 246 · see citing works
The Regulation of Chondrocyte Function by Proinflammatory Mediators
Goldring, M. B., & Berenbaum, F. (2004) · Clinical Orthopaedics and Related Research · doi:10.1097/01.blo.0000144484.69656.e4 · Cited by 243 · see citing works
Prostaglandin E2 as a mediator of fever: synthesis and catabolism
Andrei, I. I. (2004) · Frontiers in bioscience · doi:10.2741/1383 · Cited by 239 · see citing works
Regulated formation of eicosanoids
Fitzpatrick, F. A., & Soberman, R. J. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13241 · Cited by 232 · see citing works
Murakami, M., Nakatani, Y., Tanioka, T., & Kudo, I. (2002) · Prostaglandins & Other Lipid Mediators · doi:10.1016/s0090-6980(02)00043-6 · Cited by 231 · see citing works
Self-citationLeukotriene B4: Metabolism and Signal Transduction
Yokomizo, T., Izumi, T., & Shimizu, T. (2001) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.2168 · Cited by 231 · see citing works
Martey, C. A., Pollock, S. J., Turner, C. K., O’Reilly, K. M., Baglole, C. J., Phipps, R. P., & Sime, P. J. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00239.2003 · Cited by 207 · see citing works
Neufang, G., Fürstenberger, G., Heidt, M., Marks, F., & Müller‐Decker, K. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121574098 · Cited by 204 · see citing works
Prostaglandin synthases: recent developments and a novel hypothesis
Helliwell, R. J. A., Adams, L. F., & Mitchell, M. D. (2003) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2003.04.002 · Cited by 203 · see citing works
Potential Role of Microsomal Prostaglandin E Synthase-1 in Tumorigenesis
Kamei, D., Murakami, M., Nakatani, Y., Ishikawa, Y., Ishii, T., & Kudo, I. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m213290200 · Cited by 198 · see citing works
Self-citationIto, S., Okuda‐Ashitaka, E., & Minami, T. (2001) · Neuroscience Research · doi:10.1016/s0168-0102(01)00289-9 · Cited by 196 · see citing works
The Role of IL‐1 and IL‐1Ra in Joint Inflammation and Cartilage Degradation
Jacques, C., Gosset, M., Berenbaum, F., & Gabay, C. (2006) · Vitamins and hormones · doi:10.1016/s0083-6729(06)74016-x · Cited by 196 · see citing works
Coupling between Cyclooxygenase, Terminal Prostanoid Synthase, and Phospholipase A2
Ueno, N., Murakami, M., Tanioka, T., Fujimori, K., Tanabe, T., Urade, Y., & Kudo, I. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100429200 · Cited by 195 · see citing works
Self-citationPathophysiological Roles of Cyclooxygenases and Prostaglandins in the Central Nervous System
Yagami, T., Koma, H., & Yamamoto, Y. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9355-3 · Cited by 191 · see citing works
Miyaura, C., Inada, M., Matsumoto, C., Ohshiba, T., Uozumi, N., Shimizu, T., & Itô, A. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030015 · Cited by 185 · see citing works
Tang, E. H. C., & Vanhoutte, P. M. (2007) · Physiological Genomics · doi:10.1152/physiolgenomics.00136.2007 · Cited by 182 · see citing works
Claveau, D., Sirinyan, M., Guay, J., Gordon, R. J., Chan, C., Bureau, Y., Riendeau, D., & Mancini, J. A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.9.4738 · Cited by 182 · see citing works
Endotoxic fever: New concepts of its regulation suggest new approaches to its management
Blatteis, C. M. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.10.013 · Cited by 172 · see citing works
Prostaglandins as inflammatory messengers across the blood-brain barrier
Engblom, D., Ek, M., Saha, S., Ericsson‐Dahlstrand, A., Jakobsson, P., & Blomqvist, A. G. (2002) · Journal of Molecular Medicine · doi:10.1007/s00109-001-0289-z · Cited by 167 · see citing works
Sun, G. Y., Horrocks, L. A., & Farooqui, A. A. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04670.x · Cited by 169 · see citing works
Fries, G. R., Gassen, N. C., & Rein, T. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122614 · Cited by 167 · see citing works
The chemistry and biological activity of heterocycle-fused quinolinone derivatives: A review
Shiro, T., Fukaya, T., & Tobe, M. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.12.004 · Cited by 167 · see citing works
Physiologic and pathophysiologic roles of lipid mediators in the kidney
Hao, C., & Breyer, M. D. (2007) · Kidney International · doi:10.1038/sj.ki.5002192 · Cited by 167 · see citing works
Human Microsomal Prostaglandin E Synthase-1
Thorén, S., Weinander, R., Saha, S., Jegerschöld, C., Pettersson, P. L., Samuelsson, B. O., Hebert, H., Hámberg, M., Morgenstern, R., & Jakobsson, P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303227200 · Cited by 167 · see citing works
Prostaglandin E Synthase, a Terminal Enzyme for Prostaglandin E2 Biosynthesis
Kudo, I., & Murakami, M. (2005) · BMB Reports · doi:10.5483/bmbrep.2005.38.6.633 · Cited by 165 · see citing works
Self-citationThe role of prostaglandin E2 in human vascular inflammation
Gomez, I., Foudi, N., Longrois, D., & Norel, X. (2013) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2013.04.004 · Cited by 164 · see citing works
The organization and consequences of eicosanoid signaling
Soberman, R. J., & Christmas, P. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18338 · Cited by 162 · see citing works
Prostaglandin E synthases: Understanding their pathophysiological roles through mouse genetic models
Hara, S., Kamei, D., Sasaki, Y., Tanemoto, A., Nakatani, Y., & Murakami, M. (2010) · Biochimie · doi:10.1016/j.biochi.2010.02.007 · Cited by 156 · see citing works
Self-citationSmith, R. S., KELLY, R. W., Iglewski, B. H., & Phipps, R. P. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.5.2636 · Cited by 154 · see citing works
Kojima, F., Naraba, H., Miyamoto, S., Beppu, M., Aoki, H., & Kawai, S. (2004) · Arthritis Research & Therapy · doi:10.1186/ar1195 · Cited by 154 · see citing works
Han, R., Tsui, S., & Smith, T. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111246200 · Cited by 152 · see citing works
Prostaglandin E2-synthesizing enzymes in fever: differential transcriptional regulation
Ivanov, A. I., Pero, R. S., Scheck, A. C., & Romanovsky, A. A. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00347.2002 · Cited by 152 · see citing works
Neuroinflammation and anti-inflammatory therapy for Alzheimer’s disease
Moore, A. H., & O’Banion, M. K. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00162-x · Cited by 146 · see citing works
Transcriptional Regulation of the Membrane-associated Prostaglandin E2 Synthase Gene
Naraba, H., Yokoyama, C., Tago, N., Murakami, M., Kudo, I., Fueki, M., Oh‐ishi, S., & Tanabe, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203618200 · Cited by 145 · see citing works
Self-citationAchache, H., Tsafrir, A., Prus, D., Reich, R., & Revel, A. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.07.1668 · Cited by 145 · see citing works
Chell, S. D., Кади, А., Williams, A. C., & Paraskeva, C. (2006) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2006.05.002 · Cited by 144 · see citing works
Masuko, K., Berenbaum, F., Humbert, L., Salvat, C., Goldring, M. B., & Thirion, S. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20437 · Cited by 139 · see citing works
Wang, M., Lee, E., Song, W., Ricciotti, E., Rader, D. J., Lawson, J. A., Puré, E., & FitzGerald, G. A. (2008) · Circulation · doi:10.1161/circulationaha.107.731398 · Cited by 138 · see citing works
LEE, Y., KIM, H., WU, T., WANG, X., & Ra, D. (2006) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2006.01.013 · Cited by 138 · see citing works
Arikawa, T., 健, 小., & Morita, I. (2004) · Journal of Cellular Physiology · doi:10.1002/jcp.20031 · Cited by 136 · see citing works
Prostaglandins and sickness behavior: Old story, new insights
Pecchi, E., Dallaporta, M., Jean, A., Thirion, S., & Troadec, J.-D. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.02.040 · Cited by 135 · see citing works
Jabbour, H. N., Milne, S. A., Williams, A. R. W., Anderson, R. A., & Boddy, S. C. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.2033 · Cited by 135 · see citing works
Non-Steroidal Anti-Inflammatory Drugs and Brain Inflammation: Effects on Microglial Functions
Ajmone‐Cat, M. A., Bernardo, A., Greco, A., & Minghetti, L. (2010) · Pharmaceuticals · doi:10.3390/ph3061949 · Cited by 134 · see citing works
Ikeda, M., Kanao, Y., Yamanaka, M., Sakuraba, H., Mizutani, Y., Igarashi, Y., & Kihara, A. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.06.007 · Cited by 132 · see citing works
Pierzchalska, M., Szabó, Z., Sanak, M., Soja, J., & Szczeklik, A. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2003.1491 · Cited by 132 · see citing works
Inada, M., Matsumoto, C., Uematsu, S., Akira, S., & Miyaura, C. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.3.1879 · Cited by 129 · see citing works
Kuroda, E., & Yamashita, U. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.2.757 · Cited by 128 · see citing works
Coupling between cyclooxygenases and terminal prostanoid synthases
Ueno, N., Takegoshi, Y., Kamei, D., Kudo, I., & Murakami, M. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.08.152 · Cited by 128 · see citing works
Self-citationCOX-2-derived prostacyclin protects against bleomycin-induced pulmonary fibrosis
Lovgren, A. K., Jania, L. A., Hartney, J. M., Parsons, K. K., Audoly, L., FitzGerald, G. A., Tilley, S. L., & Koller, B. H. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00492.2005 · Cited by 127 · see citing works
The role of cyclooxygenase-2 in breast cancer: review
Singh‐Ranger, G., Salhab, M., & Mokbel, K. (2007) · Breast Cancer Research and Treatment · doi:10.1007/s10549-007-9641-5 · Cited by 126 · see citing works
Biochemical basis of the effect of chondroitin sulphate on osteoarthritis articular tissues
Monfort, J., Pelletier, J.-P., García‐Giralt, N., & Pelletier, J. (2007) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2006.068882 · Cited by 127 · see citing works
Koeberle, A., & Werz, O. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.06.022 · Cited by 124 · see citing works
Boulet, L., Ouellet, M., Bateman, K. P., Ethier, D., Percival, M. D., Riendeau, D., Mancini, J. A., & Méthot, N. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400443200 · Cited by 120 · see citing works
Lithium treatment inhibits renal GSK-3 activity and promotes cyclooxygenase 2-dependent polyuria
Rao, R., Zhang, M., Zhao, M., Cai, H., Harris, R. C., Breyer, M. D., & Hao, C. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00287.2004 · Cited by 119 · see citing works
Expression of microsomal prostaglandin E synthase 1 in rheumatoid arthritis synovium
Westman, M., Korotkova, M., af Klint, E., Stark, A., Audoly, L., Klareskog, L., Ulfgren, A.-K., & Jakobsson, P. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20286 · Cited by 118 · see citing works
The skeletal muscle arachidonic acid cascade in health and inflammatory disease
Korotkova, M., & Lundberg, I. E. (2014) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2014.2 · Cited by 117 · see citing works
p23, a simple protein with complex activities
Felts, S. J., & Toft, D. O. (2003) · Cell Stress and Chaperones · doi:10.1379/1466-1268(2003)008 · Cited by 116 · see citing works
Prostaglandins and bone metabolism
Choudhary, S., & Pilbeam, C. C. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814841-9.00051-8 · Cited by 116 · see citing works
The role of prostaglandins in allergic lung inflammation and asthma
Claar, D. D., Hartert, T. V., & Peebles, R. S. (2014) · Expert Review of Respiratory Medicine · doi:10.1586/17476348.2015.992783 · Cited by 113 · see citing works
Microsomal Prostaglandin E Synthase-1 Is Overexpressed in Inflammatory Bowel Disease
Subbaramaiah, K., Yoshimatsu, K., Scherl, E., Das, K. M., Glazier, K. D., Golijanin, D., Soslow, R. A., Tanabe, T., Naraba, H., & Dannenberg, A. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312972200 · Cited by 116 · see citing works
RetractedHikiji, H., Takato, T., Shimizu, T., & Ishii, S. (2007) · Progress in Lipid Research · doi:10.1016/j.plipres.2007.12.003 · Cited by 114 · see citing works
Is osteoarthritis a disease involving only cartilage or other articular tissues?
Martel‐Pelletier, J., & Pelletier, J. P. (2010) · PubMed · Cited by 113 · see citing works
Cheng, S., Afif, H., Martel‐Pelletier, J., Pelletier, J., Li, X., Farrajota, K., Lavigne, M. J. F., & Fahmi, H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402828200 · Cited by 112 · see citing works
Cyclooxygenase Inhibition as a Strategy to Ameliorate Brain Injury
Hurley, S. D., Olschowka, J. A., & O'Banion, M. K. (2002) · Journal of Neurotrauma · doi:10.1089/089771502753460196 · Cited by 110 · see citing works
Liu, T., Laidlaw, T. M., Katz, H. R., & Boyce, J. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1313185110 · Cited by 110 · see citing works
Prostaglandin synthases: Molecular characterization and involvement in prostaglandin biosynthesis
Seo, M., & Oh, D. (2017) · Progress in Lipid Research · doi:10.1016/j.plipres.2017.04.003 · Cited by 110 · see citing works
EP2 Receptor Signaling Pathways Regulate Classical Activation of Microglia
Quan, Y., Jiang, J., & Dingledine, R. J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.455816 · Cited by 108 · see citing works
Turrin, N. P., & Rivest, S. (2004) · Experimental Biology and Medicine · doi:10.1177/153537020422901003 · Cited by 107 · see citing works
Cipollone, F., Cicolini, G., & Bucci, M. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.01.002 · Cited by 105 · see citing works
Prostaglandins and Rheumatoid Arthritis
Fattahi, M. J., & Mirshafiey, A. (2012) · Arthritis · doi:10.1155/2012/239310 · Cited by 107 · see citing works
Catley, M. C., Chivers, J. E., Cambridge, L. M., Holden, N. S., Slater, D. M., Staples, K. J., Bergmann, M. W., Löser, P., Barnes, P. J., & Newton, R. C. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00672-0 · Cited by 104 · see citing works
Cyclooxygenase and 5‐lipoxygenase pathways in the vessel wall: Role in atherosclerosis
Vila, L. (2004) · Medicinal Research Reviews · doi:10.1002/med.10065 · Cited by 102 · see citing works
Prostaglandins in asthma and allergic diseases
Peebles, R. S. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.08.001 · Cited by 100 · see citing works
- Authors
- Tanioka, T., Nakatani, Y., Semmyo, N., Murakami, M., & Kudo, I.
- Affiliations
- SHOWA Medical University (JP)
- Corresponding author
- Kudo, Ichiro
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2000-10
- Volume
- 275
- Issue
- 42
- Pages
- 32775-32782
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2077641423
- Cited by
- 708
- References
- 41
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 6 · 2023: 15 · 2022: 9 · 2021: 12 · 2020: 14 · 2019: 19 · 2018: 13 · 2017: 19 · 2016: 15 · 2015: 17 · 2014: 31 · 2013: 30 · 2012: 32
- FWCI
- 25.67
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glutathione Transferases and Polymorphisms
- Keywords
- p23, cyclooxygenase-1, prostaglandin E2 synthesis, glutathione-dependent enzymes, arachidonic acid, cytosolic phospholipase A2, lipopolysaccharide, brain, cyclooxygenase-2, tissue homeostasis
- MeSH terms
- Prostaglandin-E Synthases, Amino Acid Sequence, Animals, Brain, Cell Line, Cytosol, Escherichia coli, Cricetinae, HeLa Cells, Humans, Isoenzymes, L Cells, Lipopolysaccharides, Male, Membrane Proteins, Osteoblasts, Prostaglandin-Endoperoxide Synthases, Recombinant Proteins, Dinoprostone, Mutagenesis, Site-Directed, Sequence Alignment, CHO Cells, 3T3 Cells, Rats, Wistar, Sequence Homology, Amino Acid, Intramolecular Oxidoreductases, Amino Acid Substitution, Mice, Rats, Cyclooxygenase 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review