The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trial*
Abstract
OBJECTIVE: To assess morbidity in patients with severe sepsis managed with and without drotrecogin alfa (activated). DESIGN: Analysis of secondary end points in a prospective, randomized, double-blind, placebo-controlled, multicenter, phase 3 trial (PROWESS). SETTING: A total of 164 medical institutions in 11 countries. PATIENTS: A total of 1,690 consecutive adult patients with severe sepsis. INTERVENTIONS: A 96-hr infusion of drotrecogin alfa (activated) (human recombinant activated protein C) or placebo. MEASUREMENTS AND MAIN RESULTS: Sequential Organ Failure Assessment (SOFA) scores for cardiovascular, respiratory, renal, hematologic, and hepatic organ systems were measured for 28 days. Mean cardiovascular SOFA scores were significantly lower for patients treated with drotrecogin alfa (activated) compared with placebo patients over this time period (p = .022). Drotrecogin alfa (activated)-treated patients also showed significantly faster resolution of cardiovascular (p = .009) and respiratory (p = .009) dysfunction and significantly slower onset of hematologic organ dysfunction (p = .041) compared with placebo patients for days 1 to 7. No significant differences in morbidity were observed between treatment groups among 28-day survivors. CONCLUSION: Drotrecogin alfa (activated) demonstrated significant improvements in organ function compared with placebo in a large phase 3 clinical trial that has shown a mortality benefit in patients with severe sepsis.
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Self-citationEfficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis
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Self-citationSerial Evaluation of the SOFA Score to Predict Outcome in Critically Ill Patients
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High-Dose Antithrombin III in Severe Sepsis: A Randomized Controlled Trial
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Cited by
Drotrecogin Alfa (Activated) in Adults with Septic Shock
Ranieri, V. M., Thompson, B. T., Barie, P. S., Dhainaut, J.-F., Douglas, I. S., Finfer, S., Gårdlund, B., Marshall, J. C., Rhodes, A., Artigas, A., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1202290 · Cited by 1,309
Self-citationRussell, J. A. (2006) · New England Journal of Medicine · doi:10.1056/nejmra043632 · Cited by 1,048
Levi, M., & van der Poll, T. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181c98d21 · Cited by 984
Jalilian, L., & Wiener-Kronish, J. (2018) · 50 Studies Every Intensivist Should Know · doi:10.1093/med/9780190467654.003.0019 · Cited by 937
Trzeciak, S., McCoy, J. V., Phillip Dellinger, R., Arnold, R. C., Rizzuto, M., Abate, N. L., Shapiro, N. I., Parrillo, J. E., Hollenberg, S. M., & on behalf of the Microcirculatory Alterations in Resuscitation and Shock (MARS) investigators (2008) · Intensive Care Medicine · doi:10.1007/s00134-008-1193-6 · Cited by 488
Metadata
- Authors
- Vincent, J.-L., Angus, D. C., Artigas, A., Kalil, A., Basson, B. R., Jamal, H. H., Johnson, G., & Bernard, G. R.
- Venue
- Critical Care Medicine
- Published
- 2003-03
- Volume
- 31
- Issue
- 3
- Pages
- 834-840
- ISSN
- 0090-3493 (ISSN-L)
- OpenAlex
- W1982149026
- Cited by
- 302
- References
- 22
- FWCI
- 26.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- Vincent, J.-L., Angus, D. C., Artigas, A., Kalil, A., Basson, B. R., Jamal, H. H., Johnson, G., & Bernard, G. R. (2003). Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trial*. Critical Care Medicine. https://doi.org/10.1097/01.ccm.0000051515.56179.e1
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