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Cited by 115Oral health in cancer treatmentNosocomial Infections in ICUSalivary Gland Disorders and Functions

Inadequate salivary flow and poor oral mucosal status in intubated intensive care unit patients.

Dennesen, Paul, van der Ven, André, Vlasveld, Mariel, Lokker, Linka, Ramsay, Graham, Kessels, Alphons, van den Keijbus, Petra, van Nieuw Amerongen, Arie +1 more·2003·Critical Care Medicine
DOI 10.1097/01.ccm.0000053646.04085.29
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Abstract

OBJECTIVE: To investigate salivary flow and frequency of oral mucositis in intensive care unit patients compared with patients admitted because of elective coronary artery bypass graft (CABG) surgery. In addition, the pattern of oropharyngeal colonization was investigated in these patients. DESIGN: Prospective study. SETTING: Mixed intensive care unit and cardiosurgical ward. PATIENTS: In this study, 24 ventilated intensive care unit patients and 20 CABG patients were included. MEASUREMENTS AND MAIN RESULTS: Two dental hygienists examined intensive care unit patients for the presence of periodontal disease and mucositis at admission and subsequently every week during their stay in the intensive care unit. At the same time, stimulated salivary flow and salivary total immunoglobulin A output were measured. Oropharyngeal cultures were obtained as well. CABG patients were examined the day before the operation, 1 day, 1 wk, and 2 wks after the operation. The following results were obtained: a) temporarily reduced postoperative stimulated salivary flow and total salivary immunoglobulin A output in CABG patients and nearly absent stimulated salivary flow in intensive care unit patients; b) oropharyngeal colonization with potentially pathogenic microorganisms in intensive care unit and not in CABG patients; and c) the increase in mucositis index in intensive care unit patients paralleled the increase in potentially pathogenic microorganism oropharyngeal colonization, especially and. CONCLUSIONS: Absence of adequate salivary flow in intubated intensive care unit patients causes severe xerostomia, which may contribute to the development of mucositis and oropharyngeal colonization with Gram-negative bacteria.

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Crossref · 10.1097/01.ccm.0000053646.04085.29

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  • Improving oral hygiene care can reduce the risk and mortality risk of aspiration pneumonia by as much as 60%.

    “Several studies have reported that improving oral hygiene care by either mechanical or chemical control of dental plaque biofilm formation can reduce the number of potential respiratory pathogens and consequently the risk and mortality risk of aspiration pneumonia by as much as 60% (Dennesen et al., 2003; Tuon et al., 2017).”

    From Oral Microbiome and SARS-CoV-2: Beware of Lung Co-infection (2020) · cites this paper as Dennesen et al., 2003

  • Improving oral hygiene care by either mechanical or chemical control of dental plaque biofilm formation can reduce the number of potential respiratory pathogens.

    “Several studies have reported that improving oral hygiene care by either mechanical or chemical control of dental plaque biofilm formation can reduce the number of potential respiratory pathogens and consequently the risk and mortality risk of aspiration pneumonia by as much as 60% (Dennesen et al., 2003; Tuon et al., 2017).”

    From Oral Microbiome and SARS-CoV-2: Beware of Lung Co-infection (2020) · cites this paper as Dennesen et al., 2003

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Authors
Dennesen, P., van der Ven, A., Vlasveld, M., Lokker, L., Ramsay, G., Kessels, A., van den Keijbus, P., van Nieuw Amerongen, A., & Veerman, E.
Affiliations
Maastricht University Medical Centre (NL)
ORCID
Dennesen, Paul
Venue
Critical Care Medicine
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2003-03
Volume
31
Issue
3
Pages
781-786
ISSN
0090-3493 (ISSN-L)
DOI
10.1097/01.ccm.0000053646.04085.29
OpenAlex
W2040820292
Cited by
115
References
31
Citations by year
2026: 2 · 2025: 3 · 2024: 3 · 2023: 6 · 2022: 7 · 2021: 12 · 2020: 10 · 2019: 6 · 2018: 6 · 2017: 5 · 2016: 2 · 2015: 4 · 2014: 9 · 2013: 6 · 2012: 4
FWCI
2.70
Type
journal article
Language
en
Open access
closed
Locations
  • Critical Care Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Research Publications (Maastricht University) (submittedVersion)
  • UvA-DARE (University of Amsterdam) (submittedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
  • VU Research Portal (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Oral health in cancer treatment
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
  • Health Sciences › Medicine › Physiology › Salivary Gland Disorders and Functions
Keywords
salivary flow, xerostomia, oral mucositis, oropharyngeal colonization, intensive care unit patients, mechanical ventilation, coronary artery bypass grafting, salivary IgA, periodontal disease, Gram-negative bacteria, critically ill patients
MeSH terms
Adult, Aged, Coronary Artery Bypass, Enterobacteriaceae, Female, Gram-Negative Bacteria, Humans, Immunoglobulin A, Intensive Care Units, Intubation, Intratracheal, Male, Middle Aged, Oral Hygiene, Oral Hygiene Index, Oropharynx, Postoperative Complications, Prospective Studies, Pseudomonas aeruginosa, Saliva, Salivation, Severity of Illness Index, Staphylococcus aureus, Stomatitis, Time Factors, Xerostomia

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