Cited by 118Traumatic Brain Injury and Neurovascular DisturbancesAcute Ischemic Stroke ManagementAdrenal Hormones and Disorders

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Glucocorticoid therapy in neurologic critical care

Gomes, Joao A., Stevens, Robert D., Lewin, John J., Mirski, Marek A., Bhardwaj, Anish·2005·Critical Care Medicine

DOI 10.1097/01.ccm.0000166389.85273.38

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Abstract

BACKGROUND: The pivotal role of inflammation and edema across the spectrum of central nervous system injury has driven extensive investigation into the therapeutic potential of glucocorticoids. OBJECTIVE: To review the experimental and clinical data relating to the efficacy and adverse effects of glucocorticoids in conditions encountered in critical neurologic and neurosurgical illness. DATA SOURCE: Search of MEDLINE and Cochrane databases, manual review of article bibliographies. DATA SYNTHESIS AND CONCLUSIONS: The efficacy of glucocorticoids is well established in ameliorating edema associated with brain tumors and in improving outcome in subsets of patients with bacterial meningitis. Despite frequently encouraging experimental results, clinical trials of glucocorticoids in ischemic stroke, intracerebral hemorrhage, aneurysmal subarachnoid hemorrhage, and traumatic brain injury have not shown a definite therapeutic effect. The evidence supporting glucocorticoid therapy for spinal cord injury is controversial; however methylprednisolone continues to be widely employed in this setting.

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See all 118

Authors: Gomes, J. A., Stevens, R. D., Lewin, J. J., Mirski, M. A., & Bhardwaj, A.
Affiliations: Johns Hopkins University (US)
ORCID: Gomes, Joao A.
Stevens, Robert D.
Lewin, John J.
Mirski, Marek A.
Bhardwaj, Anish
Venue: Critical Care Medicine
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2005-06
Volume: 33
Issue: 6
Pages: 1214-1224
ISSN: 0090-3493 (ISSN-L)
DOI: 10.1097/01.ccm.0000166389.85273.38
OpenAlex: W2073207619
Cited by: 118
References: 115
Citations by year: 2026: 1 · 2025: 6 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 3 · 2019: 5 · 2018: 6 · 2017: 2 · 2016: 5 · 2015: 4 · 2014: 5 · 2013: 6 · 2012: 7
FWCI: 1.92
Type: journal article
Language: en
Open access: closed
Locations: Critical Care Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Neurological Disorders and Stroke (NS046379, R01NS046379)
Topics: Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: glucocorticoids, cerebral edema, inflammation, brain tumors, bacterial meningitis, ischemic stroke, intracerebral hemorrhage, aneurysmal subarachnoid hemorrhage, traumatic brain injury, spinal cord injury, methylprednisolone, adverse effects
MeSH terms: Brain Edema, Brain Neoplasms, Central Nervous System Diseases, Central Nervous System Infections, Cerebrovascular Disorders, Glucocorticoids, Humans, Myasthenia Gravis, Trauma, Nervous System

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Glucocorticoid therapy in neurologic critical care

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